Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1464206..1465956 Replicon chromosome
Accession NZ_CP013438
Organism Burkholderia latens strain AU17928 isolate AU17928

Toxin (Protein)


Gene name doc Uniprot ID A0A1B4P1V9
Locus tag WK25_RS25830 Protein ID WP_059547325.1
Coordinates 1465060..1465956 (-) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1B4P1R9
Locus tag WK25_RS25825 Protein ID WP_059547322.1
Coordinates 1464206..1465063 (-) Length 286 a.a.

Genomic Context

WK25_RS25860WK25_RS25805WK25_RS25810WK25_RS25815WK25_RS25820WK25_RS25825WK25_RS25830WK25_RS25835WK25_RS25840WK25_RS25845WK25_RS25850WK25_RS25855
Location: 1469509..1470588 (1080 bp)
Type: Others
Protein ID: WP_059547336.1
Location: 1459345..1460835 (1491 bp)
Type: Others
Protein ID: WP_069243119.1
Location: 1460917..1461756 (840 bp)
Type: Others
Protein ID: WP_069243120.1
Location: 1461749..1463419 (1671 bp)
Type: Others
Protein ID: WP_040140232.1
Location: 1463412..1464209 (798 bp)
Type: Others
Protein ID: WP_069243121.1
Location: 1464206..1465063 (858 bp)
Type: Antitoxin
Protein ID: WP_059547322.1
Location: 1465060..1465956 (897 bp)
Type: Toxin
Protein ID: WP_059547325.1
Location: 1465975..1466502 (528 bp)
Type: Others
Protein ID: WP_040140236.1
Location: 1466537..1467307 (771 bp)
Type: Others
Protein ID: WP_040140237.1
Location: 1467300..1468370 (1071 bp)
Type: Others
Protein ID: WP_059547330.1
Location: 1468431..1468742 (312 bp)
Type: Others
Protein ID: WP_059547333.1
Location: 1468744..1469061 (318 bp)
Type: Others
Protein ID: WP_011354710.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
WK25_RS258051459345..1460835-1491WP_069243119.1aldehyde dehydrogenase-
WK25_RS258101460917..1461756-840WP_069243120.1aspartate dehydrogenase-
WK25_RS258151461749..1463419-1671WP_040140232.1thiamine pyrophosphate-binding protein-
WK25_RS258201463412..1464209-798WP_069243121.1SDR family oxidoreductase-
WK25_RS258251464206..1465063-858WP_059547322.1IclR family transcriptional regulatorAntitoxin
WK25_RS258301465060..1465956-897WP_059547325.1alpha/beta fold hydrolaseToxin
WK25_RS258351465975..1466502-528WP_040140236.1cupin domain-containing protein-
WK25_RS258401466537..1467307-771WP_040140237.1SDR family oxidoreductase-
WK25_RS258451467300..1468370-1071WP_059547330.1aromatic ring-hydroxylating dioxygenase subunit alpha-
WK25_RS258501468431..1468742-312WP_059547333.1hypothetical protein-
WK25_RS258551468744..1469061-318WP_011354710.1non-heme iron oxygenase ferredoxin subunit-
WK25_RS258601469509..1470588+1080WP_059547336.1porin-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-279)

Antitoxin

Transcription regulator IclR, C-terminal

(143-266)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30814.11 Da        Isoelectric Point: 8.3590

>T58667 WP_059547325.1 NZ_CP013438:c1465956-1465060 [Burkholderia latens]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGATGTIGYREAGAQHAGRALPVVLLHGIGSGAASWVRQLDTLGASRRVLAW
DAPGYGASTPVHGASPAAADYAASLNAWLEALGIERCVLVGHSLGAIIAGGLARVMPARIAGLLLISPAGGYGSAPAETR
DTRRDARLAMLAELGPAGLAEQRSGNMLSGFAGEEARAWVRWNMARIVPAGYAQATHLLANADLASDLAGFRGRTAVAVG
AHDAITPPAACERIAAAAHVKLQVIPQAGHAGYVEAPAVYSSLIDAFCRQCDRQRGLE

Download         Length: 897 bp

>T58667 NZ_CP013438:c1465956-1465060 [Burkholderia latens]
ATGAGTGTCATCGACAAACGTGAACGCGACCGCACCGCGGCGTTCGCCGCGCTGCTCGGGCAGTTTCCCGAACAGCGTTG
CGCGGCCGGCGCGACGGGCACGATCGGCTATCGTGAGGCCGGCGCGCAGCACGCAGGCCGCGCGCTGCCCGTCGTGCTGC
TGCACGGGATCGGCTCGGGCGCCGCATCGTGGGTGCGCCAGCTCGACACGCTAGGTGCGTCGCGGCGCGTGCTCGCGTGG
GATGCGCCCGGCTACGGCGCGTCGACGCCCGTGCACGGCGCGTCGCCGGCGGCGGCCGATTACGCGGCGTCGCTGAACGC
GTGGCTCGAGGCACTCGGCATCGAACGCTGCGTGCTGGTCGGGCATTCGCTCGGCGCGATCATCGCGGGCGGGTTGGCAC
GCGTGATGCCTGCGCGGATCGCCGGCCTGCTGCTGATCTCGCCCGCGGGCGGCTACGGCAGCGCGCCCGCCGAAACGCGC
GACACGCGGCGCGATGCGCGTCTCGCGATGCTCGCGGAACTCGGCCCGGCCGGGCTCGCGGAGCAGCGCAGCGGCAACAT
GCTGTCCGGTTTCGCGGGCGAGGAAGCACGTGCATGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGCCGGCTATGCGC
AGGCCACGCATCTGCTCGCGAACGCCGATCTCGCGTCCGACCTCGCCGGTTTTCGCGGCCGCACGGCGGTCGCGGTCGGC
GCACACGACGCGATCACGCCGCCCGCTGCATGCGAGCGGATCGCCGCGGCCGCGCACGTGAAGCTGCAGGTGATTCCGCA
GGCCGGTCATGCGGGCTACGTCGAAGCGCCGGCCGTTTATTCATCGCTGATCGATGCGTTCTGCCGCCAATGCGATCGTC
AACGGGGGCTGGAATGA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31250.68 Da        Isoelectric Point: 6.3584

>AT58667 WP_059547322.1 NZ_CP013438:c1465063-1464206 [Burkholderia latens]
MSEPLERQDTENAKSEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQAPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLAELRALYPEGTLNQMTSATPATVDALYEAIREDALRGYGVSNSSFERGISVVTAPVRNDTQKIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 858 bp

>AT58667 NZ_CP013438:c1465063-1464206 [Burkholderia latens]
ATGAGCGAACCGCTGGAACGCCAGGACACGGAAAACGCGAAGTCCGAAGCCAGCTACGTGGTGCCGGGCCTCGAACGCGG
TTTGCGGATCCTCGCCGAATTCTCGCCGCGCGAGCCGGTGCTCGGCGCGCCGGAACTGTCGAAGCGGCTCGGCATCCCCC
GCACGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGCTTTCTCGAGCGCGCCGACAAGGATCGCAACTACAAG
CTCGGCATCGCCGTGCTGCGGCTCGGTTTCGAATATCTGAGCTCGCTGGAGCTGACCGATCTCGGGCTGCCGGTGATCGA
GAGCCTGCGCGACGCGACCGGCTTCACGACGCACATCGTGATCCGCGACGGGCGCGACGTGGTGTTCGTCGCGAAGGCGC
AGAGCCAGGCGCCGGTGTTCAGCTCGATTCGCGTGAACGTCGGCACGCGGCTGCCCGCGCACGCGACGACGCACGGCCAC
GTGCTGATGGGCGACCTGTCTCTCGCGGAGTTGCGCGCGTTGTATCCGGAAGGCACGCTGAACCAGATGACGAGCGCGAC
GCCGGCAACGGTCGACGCGCTTTATGAAGCGATTCGCGAAGACGCGCTGCGCGGTTACGGCGTCAGCAATTCGTCGTTCG
AACGCGGGATCTCGGTGGTCACGGCGCCGGTGCGCAACGACACCCAGAAGATCGTCGCGTGCATCACGGTGACGGTGCCG
CGACCGGAGATCGACGCGGCGCTGATCGCCGACGGTCTGATCGACAAGGTGCAGCGCGCGGCGGCGGAACTGTCGCGGCG
GCTCAATTACCGCTCGGATGACGAGCATACGTTTCTGAAGGCATTAGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1B4P1V9

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1B4P1R9

References