Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1464206..1465956 Replicon chromosome
Accession NZ_CP013438
Organism Burkholderia latens strain AU17928 isolate AU17928

Toxin (Protein)


Gene name doc Uniprot ID A0A1B4P1V9
Locus tag WK25_RS25830 Protein ID WP_059547325.1
Coordinates 1465060..1465956 (-) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1B4P1R9
Locus tag WK25_RS25825 Protein ID WP_059547322.1
Coordinates 1464206..1465063 (-) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WK25_RS25805 1459345..1460835 - 1491 WP_069243119.1 aldehyde dehydrogenase -
WK25_RS25810 1460917..1461756 - 840 WP_069243120.1 aspartate dehydrogenase -
WK25_RS25815 1461749..1463419 - 1671 WP_040140232.1 thiamine pyrophosphate-binding protein -
WK25_RS25820 1463412..1464209 - 798 WP_069243121.1 SDR family oxidoreductase -
WK25_RS25825 1464206..1465063 - 858 WP_059547322.1 IclR family transcriptional regulator Antitoxin
WK25_RS25830 1465060..1465956 - 897 WP_059547325.1 alpha/beta fold hydrolase Toxin
WK25_RS25835 1465975..1466502 - 528 WP_040140236.1 cupin domain-containing protein -
WK25_RS25840 1466537..1467307 - 771 WP_040140237.1 SDR family oxidoreductase -
WK25_RS25845 1467300..1468370 - 1071 WP_059547330.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
WK25_RS25850 1468431..1468742 - 312 WP_059547333.1 hypothetical protein -
WK25_RS25855 1468744..1469061 - 318 WP_011354710.1 non-heme iron oxygenase ferredoxin subunit -
WK25_RS25860 1469509..1470588 + 1080 WP_059547336.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-279)

Antitoxin

Transcription regulator IclR, C-terminal

(143-266)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30814.11 Da        Isoelectric Point: 8.3590

>T58667 WP_059547325.1 NZ_CP013438:c1465956-1465060 [Burkholderia latens]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGATGTIGYREAGAQHAGRALPVVLLHGIGSGAASWVRQLDTLGASRRVLAW
DAPGYGASTPVHGASPAAADYAASLNAWLEALGIERCVLVGHSLGAIIAGGLARVMPARIAGLLLISPAGGYGSAPAETR
DTRRDARLAMLAELGPAGLAEQRSGNMLSGFAGEEARAWVRWNMARIVPAGYAQATHLLANADLASDLAGFRGRTAVAVG
AHDAITPPAACERIAAAAHVKLQVIPQAGHAGYVEAPAVYSSLIDAFCRQCDRQRGLE

Download         Length: 897 bp

>T58667 NZ_CP013438:c1465956-1465060 [Burkholderia latens]
ATGAGTGTCATCGACAAACGTGAACGCGACCGCACCGCGGCGTTCGCCGCGCTGCTCGGGCAGTTTCCCGAACAGCGTTG
CGCGGCCGGCGCGACGGGCACGATCGGCTATCGTGAGGCCGGCGCGCAGCACGCAGGCCGCGCGCTGCCCGTCGTGCTGC
TGCACGGGATCGGCTCGGGCGCCGCATCGTGGGTGCGCCAGCTCGACACGCTAGGTGCGTCGCGGCGCGTGCTCGCGTGG
GATGCGCCCGGCTACGGCGCGTCGACGCCCGTGCACGGCGCGTCGCCGGCGGCGGCCGATTACGCGGCGTCGCTGAACGC
GTGGCTCGAGGCACTCGGCATCGAACGCTGCGTGCTGGTCGGGCATTCGCTCGGCGCGATCATCGCGGGCGGGTTGGCAC
GCGTGATGCCTGCGCGGATCGCCGGCCTGCTGCTGATCTCGCCCGCGGGCGGCTACGGCAGCGCGCCCGCCGAAACGCGC
GACACGCGGCGCGATGCGCGTCTCGCGATGCTCGCGGAACTCGGCCCGGCCGGGCTCGCGGAGCAGCGCAGCGGCAACAT
GCTGTCCGGTTTCGCGGGCGAGGAAGCACGTGCATGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGCCGGCTATGCGC
AGGCCACGCATCTGCTCGCGAACGCCGATCTCGCGTCCGACCTCGCCGGTTTTCGCGGCCGCACGGCGGTCGCGGTCGGC
GCACACGACGCGATCACGCCGCCCGCTGCATGCGAGCGGATCGCCGCGGCCGCGCACGTGAAGCTGCAGGTGATTCCGCA
GGCCGGTCATGCGGGCTACGTCGAAGCGCCGGCCGTTTATTCATCGCTGATCGATGCGTTCTGCCGCCAATGCGATCGTC
AACGGGGGCTGGAATGA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31250.68 Da        Isoelectric Point: 6.3584

>AT58667 WP_059547322.1 NZ_CP013438:c1465063-1464206 [Burkholderia latens]
MSEPLERQDTENAKSEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQAPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLAELRALYPEGTLNQMTSATPATVDALYEAIREDALRGYGVSNSSFERGISVVTAPVRNDTQKIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 858 bp

>AT58667 NZ_CP013438:c1465063-1464206 [Burkholderia latens]
ATGAGCGAACCGCTGGAACGCCAGGACACGGAAAACGCGAAGTCCGAAGCCAGCTACGTGGTGCCGGGCCTCGAACGCGG
TTTGCGGATCCTCGCCGAATTCTCGCCGCGCGAGCCGGTGCTCGGCGCGCCGGAACTGTCGAAGCGGCTCGGCATCCCCC
GCACGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGCTTTCTCGAGCGCGCCGACAAGGATCGCAACTACAAG
CTCGGCATCGCCGTGCTGCGGCTCGGTTTCGAATATCTGAGCTCGCTGGAGCTGACCGATCTCGGGCTGCCGGTGATCGA
GAGCCTGCGCGACGCGACCGGCTTCACGACGCACATCGTGATCCGCGACGGGCGCGACGTGGTGTTCGTCGCGAAGGCGC
AGAGCCAGGCGCCGGTGTTCAGCTCGATTCGCGTGAACGTCGGCACGCGGCTGCCCGCGCACGCGACGACGCACGGCCAC
GTGCTGATGGGCGACCTGTCTCTCGCGGAGTTGCGCGCGTTGTATCCGGAAGGCACGCTGAACCAGATGACGAGCGCGAC
GCCGGCAACGGTCGACGCGCTTTATGAAGCGATTCGCGAAGACGCGCTGCGCGGTTACGGCGTCAGCAATTCGTCGTTCG
AACGCGGGATCTCGGTGGTCACGGCGCCGGTGCGCAACGACACCCAGAAGATCGTCGCGTGCATCACGGTGACGGTGCCG
CGACCGGAGATCGACGCGGCGCTGATCGCCGACGGTCTGATCGACAAGGTGCAGCGCGCGGCGGCGGAACTGTCGCGGCG
GCTCAATTACCGCTCGGATGACGAGCATACGTTTCTGAAGGCATTAGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4P1V9

Antitoxin

Source ID Structure
AlphaFold DB A0A1B4P1R9

References