Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 485147..485767 Replicon chromosome
Accession NZ_CP013438
Organism Burkholderia latens strain AU17928 isolate AU17928

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag WK25_RS21525 Protein ID WP_156789083.1
Coordinates 485450..485767 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag WK25_RS21520 Protein ID WP_006756590.1
Coordinates 485147..485446 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WK25_RS21495 480336..481607 + 1272 WP_040139278.1 Rieske 2Fe-2S domain-containing protein -
WK25_RS21500 481625..482110 + 486 WP_040139279.1 aromatic-ring-hydroxylating dioxygenase subunit beta -
WK25_RS21505 482137..482463 + 327 WP_040139280.1 non-heme iron oxygenase ferredoxin subunit -
WK25_RS21510 482453..483673 + 1221 WP_069242686.1 FAD-dependent oxidoreductase -
WK25_RS21515 483826..485112 + 1287 WP_059545223.1 DUF445 domain-containing protein -
WK25_RS21520 485147..485446 - 300 WP_006756590.1 putative addiction module antidote protein Antitoxin
WK25_RS21525 485450..485767 - 318 WP_156789083.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WK25_RS21530 486160..487800 + 1641 WP_069242688.1 acetolactate synthase large subunit -
WK25_RS21535 487830..489263 + 1434 WP_069242689.1 aldehyde dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(19-96)

Antitoxin

Uncharacterized protein HI1420

(4-96)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12087.77 Da        Isoelectric Point: 9.4954

>T58666 WP_156789083.1 NZ_CP013438:c485767-485450 [Burkholderia latens]
MPYSSPSYSIRTTDVFDAWFAALTDRVARRRIQARIDRLSMGNPGDWKSAGSPIVEMRIDHGPGYRVYYARRETIWVILL
CGRDKSTQQADIRAAHAMLERLDLE

Download         Length: 318 bp

>T58666 NZ_CP013438:c485767-485450 [Burkholderia latens]
ATGCCCTACAGTTCGCCTTCGTACAGTATCCGGACCACAGACGTCTTCGACGCGTGGTTTGCCGCCCTTACGGATCGCGT
CGCGCGGCGCCGCATCCAGGCGCGCATCGACCGTCTGTCGATGGGCAACCCGGGCGACTGGAAATCCGCCGGCTCACCGA
TCGTCGAAATGCGTATCGACCACGGCCCCGGCTATCGCGTCTACTACGCGAGGCGCGAAACGATATGGGTGATCCTGCTC
TGCGGCCGTGACAAGTCGACACAACAGGCGGACATCCGCGCCGCGCACGCGATGCTCGAACGGCTCGACCTGGAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10688.13 Da        Isoelectric Point: 6.6387

>AT58666 WP_006756590.1 NZ_CP013438:c485446-485147 [Burkholderia latens]
MDKIKTRPWDSAEHLKTDDDMAEYFEACLQEAGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAHA

Download         Length: 300 bp

>AT58666 NZ_CP013438:c485446-485147 [Burkholderia latens]
ATGGACAAGATCAAGACCCGGCCGTGGGATTCGGCCGAACACCTGAAAACCGACGACGACATGGCCGAGTATTTCGAGGC
CTGTCTGCAGGAAGCCGGCGACGACCCGGCCTTCATCGCGCATGCGCTTGGCGTGATCGCGCGCGCGCGCGGGATGTCGC
AGGTCGCGCGCGACGCCGGCCTGTCGCGCGAAGGGCTGTACAAGGCGCTGTCGCACGACGGCAATCCGAGCTTCGGCACG
ATCCTGAAAGTGATCAAGGCGCTCGGCCTGCAGCTGCACGGCGCGAAGGCGCACGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References