Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VagC
Location 10955..11604 Replicon plasmid pAU17928
Accession NZ_CP013436
Organism Burkholderia latens strain AU17928 isolate AU17928

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag WK25_RS15515 Protein ID WP_011695140.1
Coordinates 11194..11604 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A103EQ81
Locus tag WK25_RS15510 Protein ID WP_059569609.1
Coordinates 10955..11197 (+) Length 81 a.a.

Genomic Context

WK25_RS15510WK25_RS15515WK25_RS15520WK25_RS15525WK25_RS15530WK25_RS31260WK25_RS15535WK25_RS31265WK25_RS15540WK25_RS15545WK25_RS15550WK25_RS15500WK25_RS15505WK25_RS30495
Location: 10955..11197 (243 bp)
Type: Antitoxin
Protein ID: WP_059569609.1
Location: 11194..11604 (411 bp)
Type: Toxin
Protein ID: WP_011695140.1
Location: 11916..12263 (348 bp)
Type: Others
Protein ID: WP_069242024.1
Location: 12311..12511 (201 bp)
Type: Others
Protein ID: WP_069242025.1
Location: 12701..13414 (714 bp)
Type: Others
Protein ID: WP_083253023.1
Location: 13404..13610 (207 bp)
Type: Others
Protein ID: WP_156789038.1
Location: 13641..13874 (234 bp)
Type: Others
Protein ID: WP_156789039.1
Location: 13923..14216 (294 bp)
Type: Others
Protein ID: WP_156789040.1
Location: 14486..14929 (444 bp)
Type: Others
Protein ID: WP_069242027.1
Location: 15023..15826 (804 bp)
Type: Others
Protein ID: WP_156789041.1
Location: 15905..16522 (618 bp)
Type: Others
Protein ID: WP_069242029.1
Location: 6305..7531 (1227 bp)
Type: Others
Protein ID: WP_069242022.1
Location: 8768..9394 (627 bp)
Type: Others
Protein ID: WP_069242023.1
Location: 9391..9747 (357 bp)
Type: Others
Protein ID: WP_083253022.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
WK25_RS155006305..7531-1227WP_069242022.1replication initiation protein-
WK25_RS155058768..9394-627WP_069242023.1hypothetical protein-
WK25_RS304959391..9747-357WP_083253022.1hypothetical protein-
WK25_RS1551010955..11197+243WP_059569609.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
WK25_RS1551511194..11604+411WP_011695140.1type II toxin-antitoxin system VapC family toxinToxin
WK25_RS1552011916..12263+348WP_069242024.1hypothetical protein-
WK25_RS1552512311..12511+201WP_069242025.1hypothetical protein-
WK25_RS1553012701..13414+714WP_083253023.1helix-turn-helix domain-containing protein-
WK25_RS3126013404..13610+207WP_156789038.1hypothetical protein-
WK25_RS1553513641..13874+234WP_156789039.1hypothetical protein-
WK25_RS3126513923..14216+294WP_156789040.1hypothetical protein-
WK25_RS1554014486..14929+444WP_069242027.1hypothetical protein-
WK25_RS1554515023..15826+804WP_156789041.1HNH endonuclease-
WK25_RS1555015905..16522+618WP_069242029.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..4548145481


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin

SpoVT-AbrB domain

(12-50)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14773.00 Da        Isoelectric Point: 5.1526

>T58664 WP_011695140.1 NZ_CP013436:11194-11604 [Burkholderia latens]
MTLYLLDTNILSNVIRDPRGACATRIGETPPEQVCTSIVVAAELRFGVWKRGSSTLAQRVEQLLASLTVLPLQPDADRCY
GRLRAELEKQGQLIGANDMLIAAHALAVDAVLVTDNTAEFTRVAGLPVENWLRSAT

Download         Length: 411 bp

>T58664 NZ_CP013436:11194-11604 [Burkholderia latens]
ATGACGCTGTACCTGCTCGATACCAACATTTTGTCGAACGTGATCCGCGACCCGCGCGGCGCATGCGCCACCCGGATCGG
AGAGACCCCGCCGGAGCAAGTGTGCACCTCGATCGTCGTCGCCGCGGAACTGCGGTTCGGCGTCTGGAAGCGCGGCTCGT
CGACGCTCGCGCAGCGCGTCGAGCAACTGCTCGCGAGCCTGACCGTGTTGCCGCTGCAGCCCGACGCGGACCGCTGCTAC
GGGCGGTTGCGGGCCGAGCTCGAGAAGCAAGGCCAGCTGATCGGCGCCAACGACATGCTGATCGCCGCGCACGCGCTGGC
CGTCGACGCCGTGCTGGTCACGGACAACACGGCTGAATTCACCCGCGTTGCCGGGCTGCCGGTCGAAAACTGGCTGCGAT
CGGCGACATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9350.59 Da        Isoelectric Point: 4.6856

>AT58664 WP_059569609.1 NZ_CP013436:10955-11197 [Burkholderia latens]
MPTHDTRHARLFRNGRSQAVRIPREFELPVSEVTIHREGRRLIIEPVEAAPLRELFAQWTPLDETFPDIEDLPPEPVDIE

Download         Length: 243 bp

>AT58664 NZ_CP013436:10955-11197 [Burkholderia latens]
ATGCCAACCCATGACACCCGCCACGCGCGCCTGTTTCGCAACGGGCGCAGCCAGGCCGTGCGGATCCCGCGCGAATTCGA
ATTACCGGTCTCGGAGGTCACCATCCACCGGGAAGGCCGCCGCTTGATCATCGAGCCCGTAGAGGCCGCGCCCTTGCGCG
AGCTGTTCGCCCAATGGACCCCGCTGGACGAGACGTTTCCGGACATCGAGGACCTTCCGCCTGAACCGGTCGACATCGAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A103EQ81

References