Detailed information of TA system TA058663

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 374341..374999
• Replicon: chromosome
• Accession: NZ_CP013434
• Organism: Burkholderia vietnamiensis strain AU1233

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: WK23_RS26170
• Protein ID: WP_043292779.1
• Coordinates: 374341..374772 (-)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A1B4LJE8
• Locus tag: WK23_RS26175
• Protein ID: WP_043292778.1
• Coordinates: 374772..374999 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WK23_RS26150	370473..370877	+	405	WP_126221107.1	hypothetical protein	-
WK23_RS26155	370974..372671	+	1698	WP_046424735.1	tyrosine-type recombinase/integrase	-
WK23_RS26160	372965..373498	-	534	WP_011880200.1	RES family NAD+ phosphorylase	-
WK23_RS26165	373495..373926	-	432	WP_011880199.1	hypothetical protein	-
WK23_RS26170	374341..374772	-	432	WP_043292779.1	PIN domain-containing protein	Toxin
WK23_RS26175	374772..374999	-	228	WP_043292778.1	hypothetical protein	Antitoxin
WK23_RS31575	375796..375942	+	147	Protein_324	transposase	-
WK23_RS26185	376076..377866	+	1791	WP_011880194.1	nitrite/sulfite reductase	-
WK23_RS26190	377863..378270	+	408	WP_011880193.1	DUF934 domain-containing protein	-
WK23_RS31580	378456..379164	+	709	Protein_327	cupin domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	327432..379164	51732

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-127)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15621.97 Da
• Isoelectric Point: 7.2342

>T58663 WP_043292779.1 NZ_CP013434:c374772-374341 [Burkholderia vietnamiensis]
ITYLLDVNVLIALLDPAHVQHEPAHAWFGRVGHSAWATCPLTENGVLRIIGNPKYPNTMVSPASVAPLVVQLRSHAGHTF
WSDDVSLLDEKHVDATRLLSSAQLTDTYLLALARAHKGKLATFDRRLVVDAVPNGGKHLELIP

Nucleotide

• Length: 432 bp

>T58663 NZ_CP013434:c374772-374341 [Burkholderia vietnamiensis]
ATTACCTACCTTCTCGACGTCAACGTACTCATTGCTTTGCTCGACCCGGCACACGTTCAACACGAGCCGGCGCATGCGTG
GTTTGGCCGGGTAGGCCATTCCGCATGGGCCACGTGCCCGCTCACCGAGAACGGCGTGCTTCGAATTATCGGCAATCCGA
AATACCCGAATACGATGGTCTCTCCTGCATCCGTTGCACCGCTTGTTGTGCAACTGCGGTCCCATGCTGGGCACACATTC
TGGTCGGACGATGTGAGCCTGCTCGACGAAAAACACGTCGACGCCACCCGTTTACTGTCCTCCGCTCAACTGACCGACAC
TTACCTCCTCGCGCTCGCTCGCGCACACAAAGGCAAGTTGGCGACCTTCGATCGCCGCTTGGTCGTCGACGCGGTTCCGA
ACGGCGGGAAGCATCTTGAACTGATTCCTTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8080.14 Da
• Isoelectric Point: 8.9793

>AT58663 WP_043292778.1 NZ_CP013434:c374999-374772 [Burkholderia vietnamiensis]
MRTTIDIDDDVLAFARERAKPGTSIGKVISDLARAALQRGTTNQSSRNGLPLMPVSATARPVTLDTVNQLRDDSL

Nucleotide

• Length: 228 bp

>AT58663 NZ_CP013434:c374999-374772 [Burkholderia vietnamiensis]
ATGCGTACCACTATTGATATCGACGACGACGTCCTTGCCTTCGCGCGGGAGCGTGCAAAGCCCGGCACGAGTATCGGGAA
GGTCATTTCTGACCTCGCCCGTGCGGCCCTGCAGCGCGGAACAACGAACCAGTCGAGCCGAAACGGCTTGCCGTTGATGC
CGGTTTCCGCGACCGCCCGTCCGGTCACCCTTGATACCGTTAATCAACTTCGCGACGACTCGCTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A1B4LJE8