Detailed information of TA system TA058662

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): slvAT/RES(toxin)
• Location: 372965..373926
• Replicon: chromosome
• Accession: NZ_CP013434
• Organism: Burkholderia vietnamiensis strain AU1233

Toxin (Protein)

• Gene name: slvT
• Uniprot ID: A0A1B4LHJ3
• Locus tag: WK23_RS26160
• Protein ID: WP_011880200.1
• Coordinates: 372965..373498 (-)
• Length: 178 a.a.

Antitoxin (Protein)

• Gene name: slvA
• Uniprot ID: A0A1B4LHE0
• Locus tag: WK23_RS26165
• Protein ID: WP_011880199.1
• Coordinates: 373495..373926 (-)
• Length: 144 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WK23_RS26145	368913..370346	+	1434	WP_126221193.1	TolC family protein	-
WK23_RS26150	370473..370877	+	405	WP_126221107.1	hypothetical protein	-
WK23_RS26155	370974..372671	+	1698	WP_046424735.1	tyrosine-type recombinase/integrase	-
WK23_RS26160	372965..373498	-	534	WP_011880200.1	RES family NAD+ phosphorylase	Toxin
WK23_RS26165	373495..373926	-	432	WP_011880199.1	hypothetical protein	Antitoxin
WK23_RS26170	374341..374772	-	432	WP_043292779.1	PIN domain-containing protein	-
WK23_RS26175	374772..374999	-	228	WP_043292778.1	hypothetical protein	-
WK23_RS31575	375796..375942	+	147	Protein_324	transposase	-
WK23_RS26185	376076..377866	+	1791	WP_011880194.1	nitrite/sulfite reductase	-
WK23_RS26190	377863..378270	+	408	WP_011880193.1	DUF934 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	327432..379164	51732

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (11-168)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 178 a.a.
• Molecular weight: 19147.77 Da
• Isoelectric Point: 5.1857

>T58662 WP_011880200.1 NZ_CP013434:c373498-372965 [Burkholderia vietnamiensis]
MILKPLQDIIAYRMHQPKWAVAPTSGAGAAKAGGRANRVGTPALYLALEVATAVAEYQQLSPLLPPGTLVSYRVTAAPVV
DFTAGFRGDHWSPLWESFFCDWRRDWFNKRIEPPSWVLGDEVIAAGAKGILFSSTQAAGGTNLVLFVDQLDNTDRLEVID
PAGALPRDQASWGESPA

Nucleotide

• Length: 534 bp

>T58662 NZ_CP013434:c373498-372965 [Burkholderia vietnamiensis]
ATGATCCTCAAGCCACTGCAGGACATCATCGCGTACCGGATGCACCAGCCCAAATGGGCGGTCGCGCCCACCAGTGGCGC
CGGGGCAGCGAAGGCAGGCGGGCGGGCGAACCGGGTCGGCACGCCGGCTTTGTACCTAGCCCTCGAAGTGGCTACCGCGG
TGGCCGAGTATCAGCAGCTGTCGCCGCTGCTACCGCCTGGCACGCTCGTGAGCTATCGCGTGACGGCCGCGCCCGTCGTT
GATTTCACGGCGGGCTTTCGTGGTGACCACTGGTCGCCATTGTGGGAGTCGTTCTTCTGCGACTGGCGCCGTGACTGGTT
CAACAAGCGGATCGAGCCACCAAGCTGGGTGCTAGGCGATGAGGTGATTGCCGCCGGCGCCAAAGGCATCCTGTTTTCGT
CAACGCAGGCAGCCGGCGGCACGAACCTGGTGCTGTTCGTTGACCAACTGGACAACACCGATCGCCTGGAGGTTATCGAT
CCAGCGGGCGCCTTGCCGCGCGATCAGGCCTCGTGGGGCGAGTCTCCCGCTTGA

Antitoxin

Protein

• Length: 144 a.a.
• Molecular weight: 15299.19 Da
• Isoelectric Point: 5.6277

>AT58662 WP_011880199.1 NZ_CP013434:c373926-373495 [Burkholderia vietnamiensis]
MNTLATPSPAASAATPTGAAPVSFEAFLSSLREPDTAAPVLSARRYVAALNIDLQTLADQAHVHRNTVARAPESASVQHF
LREAIRVIRAATDLSGDVYRALFWYRNEPLAVFDYQTAETLVSAGRAEDVLRYIVSLEAGAAG

Nucleotide

• Length: 432 bp

>AT58662 NZ_CP013434:c373926-373495 [Burkholderia vietnamiensis]
ATGAACACCCTCGCGACCCCCAGCCCAGCGGCGTCTGCGGCGACGCCCACCGGTGCGGCACCCGTCAGCTTCGAGGCCTT
TCTCAGCTCGCTACGGGAACCCGACACGGCAGCACCCGTGCTGTCGGCACGACGCTATGTGGCGGCCCTGAACATCGATC
TGCAGACGCTGGCCGACCAGGCGCATGTTCACCGAAACACCGTGGCGCGAGCCCCGGAGTCGGCATCGGTTCAGCACTTC
CTGCGCGAAGCGATCCGCGTGATTCGCGCCGCGACCGACCTGTCCGGTGACGTGTACCGCGCGTTGTTCTGGTACCGCAA
CGAGCCGCTGGCGGTGTTCGATTACCAGACAGCCGAAACGCTGGTTTCCGCCGGCCGGGCCGAGGACGTGCTGCGCTACA
TCGTGTCGCTGGAAGCGGGCGCGGCCGGATGA

Structures

Toxin

• AlphaFold DB: A0A1B4LHJ3

Antitoxin

• AlphaFold DB: A0A1B4LHE0