Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 805905..806544 Replicon chromosome
Accession NZ_CP013433
Organism Burkholderia vietnamiensis strain AU1233

Toxin (Protein)


Gene name vapC Uniprot ID A0A132DRA7
Locus tag WK23_RS03650 Protein ID WP_011883463.1
Coordinates 806125..806544 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A132DHM6
Locus tag WK23_RS03645 Protein ID WP_011883461.1
Coordinates 805905..806138 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WK23_RS03635 802471..804834 + 2364 WP_069263335.1 xanthine dehydrogenase molybdopterin binding subunit -
WK23_RS03640 804922..805578 + 657 WP_059669209.1 xanthine dehydrogenase accessory protein XdhC -
WK23_RS03645 805905..806138 + 234 WP_011883461.1 DNA-binding protein Antitoxin
WK23_RS03650 806125..806544 + 420 WP_011883463.1 type II toxin-antitoxin system VapC family toxin Toxin
WK23_RS03655 806674..807075 + 402 WP_069263337.1 polyketide cyclase -
WK23_RS03660 807116..808060 - 945 WP_011883467.1 LysR family transcriptional regulator -
WK23_RS03665 808130..808768 - 639 WP_011883469.1 2-hydroxychromene-2-carboxylate isomerase -
WK23_RS03670 808863..810296 - 1434 WP_011883471.1 ABC transporter substrate-binding protein -
WK23_RS03675 810765..811130 + 366 WP_059567237.1 BON domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15649.85 Da        Isoelectric Point: 6.0999

>T58658 WP_011883463.1 NZ_CP013433:806125-806544 [Burkholderia vietnamiensis]
MFLVDTNVISEVRKRERADKGVMAFFRKAAQDDADLYLSVVTVGELRRGVEIIRHRGDKSQATRLENWLDGVLREFASNI
LAVDEEIGQLWGRLRVPHPEHSLDKLIAATALIHDLIVVTRNVDDFAGTGARVLNPFES

Download         Length: 420 bp

>T58658 NZ_CP013433:806125-806544 [Burkholderia vietnamiensis]
ATGTTTTTGGTTGATACCAACGTCATCAGCGAAGTACGGAAGCGGGAGCGAGCAGATAAAGGTGTGATGGCGTTTTTCCG
CAAGGCCGCGCAGGACGATGCCGATCTGTACCTTTCCGTGGTGACGGTTGGCGAACTGCGGCGCGGTGTGGAAATCATCC
GTCACCGTGGCGACAAGTCCCAGGCGACGCGCCTTGAAAACTGGCTCGATGGCGTACTTCGGGAGTTTGCGTCGAACATT
CTGGCGGTGGACGAAGAGATCGGGCAGTTGTGGGGACGCCTGCGCGTCCCGCATCCCGAGCACTCGCTCGACAAGTTGAT
CGCGGCAACGGCGTTGATCCACGACCTGATCGTCGTGACGCGGAACGTCGATGATTTCGCCGGAACGGGCGCACGCGTTC
TGAACCCATTCGAAAGCTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8379.44 Da        Isoelectric Point: 5.0644

>AT58658 WP_011883461.1 NZ_CP013433:805905-806138 [Burkholderia vietnamiensis]
MATLLVRNVDEELVQSLRERAAANGRSAEAEHREILAKALRAPQRKTFAQVLMSIPNVGTDADFARVDDGEAANVFG

Download         Length: 234 bp

>AT58658 NZ_CP013433:805905-806138 [Burkholderia vietnamiensis]
ATGGCAACTCTTCTGGTGAGAAATGTGGACGAGGAACTCGTCCAAAGCCTGCGCGAGCGGGCCGCAGCCAACGGGCGCAG
TGCGGAGGCCGAGCATCGAGAGATCCTGGCAAAGGCGCTGCGCGCGCCGCAGCGCAAGACGTTCGCGCAGGTGTTGATGA
GTATCCCGAACGTCGGAACCGATGCCGATTTTGCGCGCGTGGATGACGGCGAGGCAGCGAATGTTTTTGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A132DRA7

Antitoxin

Source ID Structure
AlphaFold DB A0A132DHM6

References