Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 158012..158649 Replicon chromosome
Accession NZ_CP013433
Organism Burkholderia vietnamiensis strain AU1233

Toxin (Protein)


Gene name vapC Uniprot ID I2DIN1
Locus tag WK23_RS00665 Protein ID WP_014722201.1
Coordinates 158248..158649 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A132E2H4
Locus tag WK23_RS00660 Protein ID WP_060081205.1
Coordinates 158012..158248 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WK23_RS00645 153606..154640 + 1035 WP_034192975.1 helix-turn-helix domain-containing protein -
WK23_RS00650 154907..156034 - 1128 WP_060044404.1 hypothetical protein -
WK23_RS00655 156031..157734 - 1704 WP_059889397.1 thiamine pyrophosphate-binding protein -
WK23_RS00660 158012..158248 + 237 WP_060081205.1 AbrB family transcriptional regulator Antitoxin
WK23_RS00665 158248..158649 + 402 WP_014722201.1 type II toxin-antitoxin system VapC family toxin Toxin
WK23_RS00670 158717..160105 - 1389 WP_059568060.1 L-serine ammonia-lyase -
WK23_RS00675 160136..161272 - 1137 WP_045578623.1 alginate lyase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14908.05 Da        Isoelectric Point: 5.1684

>T58657 WP_014722201.1 NZ_CP013433:158248-158649 [Burkholderia vietnamiensis]
MPRYMLDTNMCIYLMKSQPEQVAKRFAQCYTGDVVMSAITYAELEYGVTACAAPARERRHLAALIEDIPVAPFDAAAAQA
YGPVRDATRAWKKDHLDKLIAAHAVSLDVVLVTNDERDFTSYPGLRLENWLND

Download         Length: 402 bp

>T58657 NZ_CP013433:158248-158649 [Burkholderia vietnamiensis]
ATGCCGCGTTACATGCTCGACACCAACATGTGCATCTACTTGATGAAGAGCCAGCCCGAGCAAGTGGCGAAGCGATTTGC
GCAGTGCTACACGGGCGACGTCGTGATGTCGGCGATCACGTATGCCGAGCTGGAGTACGGCGTCACCGCTTGCGCGGCGC
CCGCGCGTGAGCGCCGCCATCTTGCGGCGCTGATCGAGGATATTCCCGTCGCGCCGTTCGACGCCGCGGCCGCGCAAGCA
TATGGGCCCGTGCGTGACGCAACGCGCGCATGGAAGAAGGATCATCTCGACAAACTGATCGCCGCTCATGCGGTGTCGCT
CGATGTCGTGCTGGTGACGAATGACGAGCGCGATTTCACGAGCTATCCGGGATTGCGGCTGGAGAACTGGCTGAACGATT
AG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8968.16 Da        Isoelectric Point: 6.4648

>AT58657 WP_060081205.1 NZ_CP013433:158012-158248 [Burkholderia vietnamiensis]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIECIGDEIRIRPARRPLTQVLKKFAKFAPDFMAEGRGDHEQAEREGL

Download         Length: 237 bp

>AT58657 NZ_CP013433:158012-158248 [Burkholderia vietnamiensis]
ATGCATACCACGAGGGTATTTCGGAACGGCAATTCGCAGGCCGTGCGAATTCCTGCGGATCTCGCTTATGAGCGCAGCGA
TATCGAGCTCGAGATCGAGTGCATCGGCGACGAGATCCGCATCCGGCCGGCGCGACGGCCGTTGACGCAGGTGCTCAAGA
AGTTCGCGAAGTTCGCGCCCGATTTCATGGCGGAAGGGCGTGGCGACCACGAGCAGGCCGAACGCGAGGGGTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I2DIN1

Antitoxin

Source ID Structure
AlphaFold DB A0A132E2H4

References