Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 2067924..2068544 Replicon chromosome
Accession NZ_CP013431
Organism Burkholderia multivorans strain AU1185 isolate AU1185

Toxin (Protein)


Gene name relE Uniprot ID A0A0H3KJN2
Locus tag WK22_RS25055 Protein ID WP_012217495.1
Coordinates 2067924..2068241 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID B9B269
Locus tag WK22_RS25060 Protein ID WP_006398012.1
Coordinates 2068245..2068544 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WK22_RS25045 2064457..2065890 - 1434 WP_069221287.1 aldehyde dehydrogenase family protein -
WK22_RS25050 2065919..2067559 - 1641 WP_006398015.1 acetolactate synthase large subunit -
WK22_RS25055 2067924..2068241 + 318 WP_012217495.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WK22_RS25060 2068245..2068544 + 300 WP_006398012.1 putative addiction module antidote protein Antitoxin
WK22_RS25065 2068579..2069865 - 1287 WP_035487943.1 DUF445 domain-containing protein -
WK22_RS25070 2069980..2071200 - 1221 WP_069221288.1 FAD-dependent oxidoreductase -
WK22_RS25075 2071190..2071516 - 327 WP_006404219.1 non-heme iron oxygenase ferredoxin subunit -
WK22_RS25080 2071534..2072022 - 489 WP_006398008.1 aromatic-ring-hydroxylating dioxygenase subunit beta -
WK22_RS25085 2072037..2073308 - 1272 WP_069221289.1 Rieske 2Fe-2S domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(9-102)

Antitoxin

Uncharacterized protein HI1420

(4-96)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.94 Da        Isoelectric Point: 10.2349

>T58656 WP_012217495.1 NZ_CP013431:2067924-2068241 [Burkholderia multivorans]
MPYLAPTFSIRTTAVFDAWFAGLQDRTAKRRIQARIDRLSMGNLGNWKSVGSPVYEMRIDHGPGYRVYFVRRRTIWVVLL
CGGDKSTQRDDIRAAHAMLEHLDLE

Download         Length: 318 bp

>T58656 NZ_CP013431:2067924-2068241 [Burkholderia multivorans]
ATGCCTTACCTTGCTCCAACGTTCAGCATCCGGACGACCGCCGTGTTCGACGCGTGGTTTGCCGGCCTGCAGGACCGCAC
CGCGAAGCGCCGCATTCAGGCGCGCATCGATCGGCTGTCGATGGGCAATCTGGGCAACTGGAAGTCCGTCGGGTCGCCCG
TCTACGAGATGCGCATCGATCACGGCCCCGGCTATCGCGTGTACTTCGTGCGGCGGCGCACGATATGGGTCGTCCTGCTG
TGCGGCGGCGACAAATCCACGCAGCGCGACGACATTCGCGCCGCCCATGCGATGCTCGAGCATCTCGACCTGGAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10605.00 Da        Isoelectric Point: 6.6381

>AT58656 WP_006398012.1 NZ_CP013431:2068245-2068544 [Burkholderia multivorans]
MSKISTRPWDSAEHLKTDDDMAEYFEACLQEGGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAHA

Download         Length: 300 bp

>AT58656 NZ_CP013431:2068245-2068544 [Burkholderia multivorans]
ATGAGCAAGATCAGCACGCGGCCGTGGGATTCGGCCGAACACCTGAAGACCGACGACGACATGGCCGAGTATTTCGAAGC
TTGCCTCCAGGAAGGCGGCGACGATCCGGCATTCATCGCGCACGCGCTCGGCGTGATCGCGCGCGCCCGCGGCATGTCGC
AAGTCGCGCGCGATGCGGGGCTATCGCGCGAGGGGCTGTACAAGGCGCTGTCGCACGACGGCAATCCCAGCTTCGGCACG
ATCCTCAAAGTGATCAAGGCGCTCGGCCTGCAACTGCACGGCGCGAAAGCGCACGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3KJN2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3KTI5

References