58655

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 1475179..1476217 Replicon chromosome
Accession NZ_CP013431
Organism Burkholderia multivorans strain AU1185 isolate AU1185

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag WK22_RS22505 Protein ID WP_006403678.1
Coordinates 1475179..1475661 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag WK22_RS22510 Protein ID WP_069221130.1
Coordinates 1475750..1476217 (-) Length 156 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WK22_RS22480 1470307..1471374 + 1068 WP_069221127.1 ABC transporter ATP-binding protein -
WK22_RS22485 1471592..1472674 + 1083 WP_006403670.1 porin -
WK22_RS22490 1472740..1473699 - 960 WP_069221128.1 zinc-binding alcohol dehydrogenase family protein -
WK22_RS22495 1473778..1474029 - 252 WP_039218251.1 hypothetical protein -
WK22_RS22500 1474125..1474934 + 810 WP_069221129.1 helix-turn-helix transcriptional regulator -
WK22_RS22505 1475179..1475661 - 483 WP_006403678.1 PIN domain-containing protein Toxin
WK22_RS22510 1475750..1476217 - 468 WP_069221130.1 helix-turn-helix domain-containing protein Antitoxin
WK22_RS22515 1476333..1477139 - 807 WP_069221131.1 4-hydroxy-2-oxoheptanedioate aldolase -
WK22_RS22520 1477147..1477950 - 804 WP_006402377.1 2-oxo-hepta-3-ene-1,7-dioic acid hydratase -
WK22_RS22525 1477965..1478357 - 393 WP_069221132.1 5-carboxymethyl-2-hydroxymuconate Delta-isomerase -
WK22_RS22530 1478393..1479241 - 849 WP_069221493.1 3,4-dihydroxyphenylacetate 2,3-dioxygenase -
WK22_RS22535 1479284..1480747 - 1464 WP_065495029.1 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-84)

Antitoxin

Helix-turn-helix domain, group 17

(84-132)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 18130.61 Da        Isoelectric Point: 4.7272

>T58655 WP_006403678.1 NZ_CP013431:c1475661-1475179 [Burkholderia multivorans]
MFRARWSAHITDEWKRNLLDNRPDLTAEQLDRTSSLMDRAIPDAVVTGYESLIAGLVLPDADDRHVLAAAIRCNASVIVT
FNRKDFPEEALLPYGIEAQHPDEFVDDLFDLEPAVVVAAARRQREALKQPPLTADRYLEILRRQGMVQTCQSLDAYRALL

Download         Length: 483 bp

>T58655 NZ_CP013431:c1475661-1475179 [Burkholderia multivorans]
ATGTTTCGGGCGCGGTGGAGCGCACATATTACCGACGAGTGGAAGCGCAATCTGTTGGACAACCGTCCGGATTTGACAGC
GGAACAGCTTGATCGAACCTCAAGTTTGATGGATCGAGCGATACCGGATGCCGTCGTGACCGGTTATGAATCGTTGATTG
CCGGGCTTGTTCTCCCGGATGCCGACGATCGTCACGTGCTTGCCGCTGCAATCCGTTGCAACGCCAGCGTGATCGTGACG
TTCAATCGAAAGGACTTTCCGGAAGAGGCGTTGTTGCCGTACGGCATCGAGGCCCAGCATCCAGACGAGTTCGTCGATGA
TCTTTTCGACCTCGAACCCGCGGTGGTCGTTGCGGCCGCGCGACGACAGCGAGAGGCGCTTAAACAACCACCGTTGACTG
CAGACCGGTACCTCGAGATCTTGCGACGACAAGGCATGGTGCAGACGTGTCAGTCGCTCGACGCCTATCGAGCACTTCTT
TGA

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17678.10 Da        Isoelectric Point: 6.0751

>AT58655 WP_069221130.1 NZ_CP013431:c1476217-1475750 [Burkholderia multivorans]
MHHATTPDMILPVEREMQAAVEGQRMLAAYLATRTDTQRIQIFDDENRAHQVELPTSALRLLVDILAELADGNAVKVVPV
HAELTTQEAADLLNVSRPHLIKLLESHALPYHRTGKHRRVRFSDLMRYKAERDQESADAMEELSKQAQDLRMGYE

Download         Length: 468 bp

>AT58655 NZ_CP013431:c1476217-1475750 [Burkholderia multivorans]
ATGCATCACGCCACGACACCCGACATGATCTTGCCCGTCGAGCGCGAGATGCAGGCGGCCGTCGAGGGGCAACGCATGCT
GGCGGCTTATCTCGCAACACGGACCGATACGCAGCGCATTCAGATTTTTGATGACGAGAACCGAGCCCATCAGGTCGAGC
TGCCGACGTCCGCACTTCGTCTGCTGGTGGATATTCTCGCGGAATTGGCGGATGGCAACGCTGTCAAGGTTGTGCCGGTT
CATGCGGAATTGACGACGCAGGAAGCGGCAGATCTGCTCAATGTCTCCCGCCCGCATCTGATCAAGCTGCTTGAGTCGCA
TGCATTGCCCTATCACCGGACGGGCAAGCATCGGCGCGTGCGGTTTTCGGATCTGATGCGCTACAAGGCTGAGCGCGACC
AAGAGAGTGCTGACGCAATGGAAGAACTGAGCAAGCAGGCACAGGATCTGCGGATGGGCTACGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References