Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | chpSB/PRK09812-ChpS |
Location | 373910..374505 | Replicon | chromosome |
Accession | NZ_CP013431 | ||
Organism | Burkholderia multivorans strain AU1185 isolate AU1185 |
Toxin (Protein)
Gene name | chpB | Uniprot ID | B9B2F6 |
Locus tag | WK22_RS17915 | Protein ID | WP_006397259.1 |
Coordinates | 373910..374260 (-) | Length | 117 a.a. |
Antitoxin (Protein)
Gene name | chpS | Uniprot ID | B9B2F5 |
Locus tag | WK22_RS17920 | Protein ID | WP_006397258.1 |
Coordinates | 374254..374505 (-) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
WK22_RS17905 | 369002..372187 | + | 3186 | WP_006397262.1 | multidrug efflux RND transporter permease subunit CeoB | - |
WK22_RS17910 | 372198..373730 | + | 1533 | WP_043279069.1 | multidrug efflux transporter outer membrane subunit OpcM | - |
WK22_RS17915 | 373910..374260 | - | 351 | WP_006397259.1 | type II toxin-antitoxin system ChpB family toxin | Toxin |
WK22_RS17920 | 374254..374505 | - | 252 | WP_006397258.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
WK22_RS17925 | 375062..376555 | - | 1494 | WP_006397257.1 | M81 family metallopeptidase | - |
WK22_RS17930 | 376656..377960 | - | 1305 | WP_039222447.1 | MFS transporter | - |
WK22_RS17935 | 378102..379073 | + | 972 | WP_006397255.1 | LysR family transcriptional regulator | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12423.44 Da Isoelectric Point: 8.9128
>T58650 WP_006397259.1 NZ_CP013431:c374260-373910 [Burkholderia multivorans]
MVKRVKFERGDIVRVSLNPTLGREHQGDFRPALVLSPAAFNALGVALVAPITQGGEFARFAGFAVPLSGAGTETQGVALV
NMVRMLDLEARGARKVERAPVEVVEDALARLQTIIE
MVKRVKFERGDIVRVSLNPTLGREHQGDFRPALVLSPAAFNALGVALVAPITQGGEFARFAGFAVPLSGAGTETQGVALV
NMVRMLDLEARGARKVERAPVEVVEDALARLQTIIE
Download Length: 351 bp
>T58650 NZ_CP013431:c374260-373910 [Burkholderia multivorans]
ATGGTGAAGCGCGTCAAGTTCGAGCGAGGCGATATCGTGCGCGTGAGCCTGAATCCGACTCTCGGTCGTGAGCACCAGGG
CGACTTTCGTCCGGCGCTGGTGCTCTCCCCGGCAGCGTTCAACGCTTTGGGCGTTGCGCTGGTCGCACCGATCACCCAGG
GTGGCGAATTTGCGCGGTTCGCAGGGTTCGCGGTCCCGCTGTCCGGTGCAGGAACCGAGACGCAGGGCGTCGCGCTGGTG
AACATGGTTCGCATGCTCGACCTGGAGGCGCGCGGCGCTCGCAAGGTCGAACGCGCGCCTGTCGAGGTCGTGGAAGATGC
ACTCGCCCGGCTTCAGACGATCATCGAATAA
ATGGTGAAGCGCGTCAAGTTCGAGCGAGGCGATATCGTGCGCGTGAGCCTGAATCCGACTCTCGGTCGTGAGCACCAGGG
CGACTTTCGTCCGGCGCTGGTGCTCTCCCCGGCAGCGTTCAACGCTTTGGGCGTTGCGCTGGTCGCACCGATCACCCAGG
GTGGCGAATTTGCGCGGTTCGCAGGGTTCGCGGTCCCGCTGTCCGGTGCAGGAACCGAGACGCAGGGCGTCGCGCTGGTG
AACATGGTTCGCATGCTCGACCTGGAGGCGCGCGGCGCTCGCAAGGTCGAACGCGCGCCTGTCGAGGTCGTGGAAGATGC
ACTCGCCCGGCTTCAGACGATCATCGAATAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9007.36 Da Isoelectric Point: 6.2420
>AT58650 WP_006397258.1 NZ_CP013431:c374505-374254 [Burkholderia multivorans]
MELKIQKWGNSAAVRLPSVLLEQINATVGSSLSADVRPDGVLLTPARRKYSLDDLVAQCDTKAPFPADMAAWGEVKPVGR
EAW
MELKIQKWGNSAAVRLPSVLLEQINATVGSSLSADVRPDGVLLTPARRKYSLDDLVAQCDTKAPFPADMAAWGEVKPVGR
EAW
Download Length: 252 bp
>AT58650 NZ_CP013431:c374505-374254 [Burkholderia multivorans]
ATGGAACTCAAGATTCAAAAATGGGGCAATAGCGCGGCGGTTCGTTTGCCCAGCGTTCTGCTCGAACAGATCAACGCGAC
GGTCGGCAGTTCGCTGAGCGCGGACGTGCGCCCGGATGGCGTGTTGTTGACGCCGGCCCGCCGCAAGTATTCGCTCGATG
ATCTCGTTGCCCAATGCGACACGAAAGCGCCTTTCCCTGCCGACATGGCTGCATGGGGCGAGGTCAAGCCGGTGGGGCGT
GAGGCATGGTGA
ATGGAACTCAAGATTCAAAAATGGGGCAATAGCGCGGCGGTTCGTTTGCCCAGCGTTCTGCTCGAACAGATCAACGCGAC
GGTCGGCAGTTCGCTGAGCGCGGACGTGCGCCCGGATGGCGTGTTGTTGACGCCGGCCCGCCGCAAGTATTCGCTCGATG
ATCTCGTTGCCCAATGCGACACGAAAGCGCCTTTCCCTGCCGACATGGCTGCATGGGGCGAGGTCAAGCCGGTGGGGCGT
GAGGCATGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | B9B2F6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A132EKI4 |