Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 373910..374505 Replicon chromosome
Accession NZ_CP013431
Organism Burkholderia multivorans strain AU1185 isolate AU1185

Toxin (Protein)


Gene name chpB Uniprot ID B9B2F6
Locus tag WK22_RS17915 Protein ID WP_006397259.1
Coordinates 373910..374260 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID B9B2F5
Locus tag WK22_RS17920 Protein ID WP_006397258.1
Coordinates 374254..374505 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WK22_RS17905 369002..372187 + 3186 WP_006397262.1 multidrug efflux RND transporter permease subunit CeoB -
WK22_RS17910 372198..373730 + 1533 WP_043279069.1 multidrug efflux transporter outer membrane subunit OpcM -
WK22_RS17915 373910..374260 - 351 WP_006397259.1 type II toxin-antitoxin system ChpB family toxin Toxin
WK22_RS17920 374254..374505 - 252 WP_006397258.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
WK22_RS17925 375062..376555 - 1494 WP_006397257.1 M81 family metallopeptidase -
WK22_RS17930 376656..377960 - 1305 WP_039222447.1 MFS transporter -
WK22_RS17935 378102..379073 + 972 WP_006397255.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12423.44 Da        Isoelectric Point: 8.9128

>T58650 WP_006397259.1 NZ_CP013431:c374260-373910 [Burkholderia multivorans]
MVKRVKFERGDIVRVSLNPTLGREHQGDFRPALVLSPAAFNALGVALVAPITQGGEFARFAGFAVPLSGAGTETQGVALV
NMVRMLDLEARGARKVERAPVEVVEDALARLQTIIE

Download         Length: 351 bp

>T58650 NZ_CP013431:c374260-373910 [Burkholderia multivorans]
ATGGTGAAGCGCGTCAAGTTCGAGCGAGGCGATATCGTGCGCGTGAGCCTGAATCCGACTCTCGGTCGTGAGCACCAGGG
CGACTTTCGTCCGGCGCTGGTGCTCTCCCCGGCAGCGTTCAACGCTTTGGGCGTTGCGCTGGTCGCACCGATCACCCAGG
GTGGCGAATTTGCGCGGTTCGCAGGGTTCGCGGTCCCGCTGTCCGGTGCAGGAACCGAGACGCAGGGCGTCGCGCTGGTG
AACATGGTTCGCATGCTCGACCTGGAGGCGCGCGGCGCTCGCAAGGTCGAACGCGCGCCTGTCGAGGTCGTGGAAGATGC
ACTCGCCCGGCTTCAGACGATCATCGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9007.36 Da        Isoelectric Point: 6.2420

>AT58650 WP_006397258.1 NZ_CP013431:c374505-374254 [Burkholderia multivorans]
MELKIQKWGNSAAVRLPSVLLEQINATVGSSLSADVRPDGVLLTPARRKYSLDDLVAQCDTKAPFPADMAAWGEVKPVGR
EAW

Download         Length: 252 bp

>AT58650 NZ_CP013431:c374505-374254 [Burkholderia multivorans]
ATGGAACTCAAGATTCAAAAATGGGGCAATAGCGCGGCGGTTCGTTTGCCCAGCGTTCTGCTCGAACAGATCAACGCGAC
GGTCGGCAGTTCGCTGAGCGCGGACGTGCGCCCGGATGGCGTGTTGTTGACGCCGGCCCGCCGCAAGTATTCGCTCGATG
ATCTCGTTGCCCAATGCGACACGAAAGCGCCTTTCCCTGCCGACATGGCTGCATGGGGCGAGGTCAAGCCGGTGGGGCGT
GAGGCATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B9B2F6

Antitoxin

Source ID Structure
AlphaFold DB A0A132EKI4

References