Detailed information of TA system TA058648

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-vagC/VapC-VagC
• Location: 148100..148737
• Replicon: chromosome
• Accession: NZ_CP013430
• Organism: Burkholderia multivorans strain AU1185 isolate AU1185

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: WK22_RS00650
• Protein ID: WP_069219848.1
• Coordinates: 148336..148737 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: -
• Locus tag: WK22_RS00645
• Protein ID: WP_069219847.1
• Coordinates: 148100..148336 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WK22_RS00625	143252..143794	+	543	WP_006408276.1	hypothetical protein	-
WK22_RS00630	143965..144996	+	1032	WP_012212492.1	helix-turn-helix domain-containing protein	-
WK22_RS00635	145115..146212	-	1098	WP_069219845.1	ADP-heptose--LPS heptosyltransferase	-
WK22_RS00640	146209..147912	-	1704	WP_069219846.1	thiamine pyrophosphate-binding protein	-
WK22_RS00645	148100..148336	+	237	WP_069219847.1	AbrB family transcriptional regulator	Antitoxin
WK22_RS00650	148336..148737	+	402	WP_069219848.1	type II toxin-antitoxin system VapC family toxin	Toxin
WK22_RS00655	148859..150247	-	1389	WP_006408285.1	L-serine ammonia-lyase	-
WK22_RS00660	150274..151416	-	1143	WP_053296686.1	alginate lyase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-121)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14949.15 Da
• Isoelectric Point: 5.7429

>T58648 WP_069219848.1 NZ_CP013430:148336-148737 [Burkholderia multivorans]
MPRYMLDTNMCIYLMKNQPEQVARRFAQCYTGDVVMSAVTYAELEYGVTLCANPARERRNLAALIEDIPVAPFDGAAAQA
YGPIREATRERKKDHLDKLIGAHAVSLDVVLVTNNERDFASYPGLRLENWLIG

Nucleotide

• Length: 402 bp

>T58648 NZ_CP013430:148336-148737 [Burkholderia multivorans]
ATGCCGCGCTACATGCTCGACACCAACATGTGCATCTATCTGATGAAGAACCAGCCGGAGCAGGTCGCGCGGCGTTTCGC
GCAGTGCTACACGGGGGACGTCGTCATGTCGGCGGTCACCTATGCGGAGCTCGAGTACGGCGTGACGCTATGCGCCAATC
CGGCCCGCGAACGCCGCAATCTCGCCGCGCTGATCGAGGATATCCCGGTGGCGCCGTTCGACGGAGCGGCTGCGCAGGCA
TACGGCCCCATTCGAGAGGCGACGCGCGAACGCAAGAAGGATCATCTCGACAAGCTGATCGGCGCGCACGCCGTATCGCT
CGACGTCGTGCTGGTGACCAACAACGAGCGTGATTTCGCGAGTTATCCGGGCTTGAGGCTGGAGAACTGGCTGATCGGCT
AG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8946.01 Da
• Isoelectric Point: 5.8651

>AT58648 WP_069219847.1 NZ_CP013430:148100-148336 [Burkholderia multivorans]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERVGDEIRIRPARRQLTGVLGKFAKFGPDFMAEGRGDQEQAEREGW

Nucleotide

• Length: 237 bp

>AT58648 NZ_CP013430:148100-148336 [Burkholderia multivorans]
ATGCATACCACCCGGGTCTTCCGGAATGGCAACTCGCAGGCGGTGCGGATTCCTGCGGATCTTGCTTATGAGCGCAGCGA
TATCGAACTCGAAATCGAGCGTGTCGGTGACGAAATTCGCATCCGGCCTGCGCGGCGGCAGCTGACCGGCGTGCTCGGCA
AGTTCGCGAAATTCGGGCCCGATTTCATGGCCGAGGGGCGCGGCGATCAGGAACAGGCCGAGCGCGAGGGTTGGTGA