Detailed information of TA system TA058647

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 1854080..1855304
• Replicon: chromosome
• Accession: NZ_CP013428
• Organism: Burkholderia sp. MSMB0856

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: WS87_RS25885
• Protein ID: WP_059819476.1
• Coordinates: 1854723..1855304 (+)
• Length: 194 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: WS87_RS25880
• Protein ID: WP_059819475.1
• Coordinates: 1854080..1854637 (+)
• Length: 186 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WS87_RS25865	1850657..1851292	+	636	WP_059819472.1	cysteine hydrolase	-
WS87_RS25870	1851359..1852090	-	732	WP_059819473.1	ribonuclease T2	-
WS87_RS25875	1852394..1853797	-	1404	WP_059819474.1	hypothetical protein	-
WS87_RS25880	1854080..1854637	+	558	WP_059819475.1	helix-turn-helix domain-containing protein	Antitoxin
WS87_RS25885	1854723..1855304	+	582	WP_059819476.1	HD domain-containing protein	Toxin
WS87_RS25890	1855340..1856878	-	1539	WP_059819477.1	MFS transporter	-
WS87_RS25895	1857056..1857961	+	906	WP_059819478.1	LysR family transcriptional regulator	-
WS87_RS25900	1858034..1859173	-	1140	WP_059699172.1	enoyl-CoA hydratase/isomerase family protein	-
WS87_RS25905	1859170..1859961	-	792	WP_059819479.1	enoyl-CoA hydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-169)

Antitoxin

• Cro/C1-type helix-turn-helix domain (12-61)

Sequences

Toxin

Protein

• Length: 194 a.a.
• Molecular weight: 21301.81 Da
• Isoelectric Point: 4.9532

>T58647 WP_059819476.1 NZ_CP013428:1854723-1855304 [Burkholderia sp. MSMB0856]
MNLDTIHARLDFLREAERLKNVLRSGHTSTGRAESTAEHSWRLCLMALVFADALPDVDTTKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSTHERDDLLTLTAGLDRALRDEIVALWDEYEAAASSEARAAKALDKLETILQHNQGSNPPDFDYAFNLGY
GRRYTDAAPLFGAIRAIVDADTQRRIDARGDGT

Nucleotide

• Length: 582 bp

>T58647 NZ_CP013428:1854723-1855304 [Burkholderia sp. MSMB0856]
ATGAACCTCGACACGATCCACGCGCGGCTCGATTTCCTGCGCGAAGCCGAACGCCTGAAAAACGTGCTGCGCAGCGGCCA
TACGTCGACCGGGCGCGCCGAAAGCACGGCCGAACACAGCTGGCGGCTGTGCCTGATGGCGCTCGTGTTCGCCGATGCGC
TGCCGGACGTCGACACGACAAAGCTGCTGAAGCTGTGCGTCGTCCACGATCTCGGCGAAGCGCTGCACGGCGACATCCCC
GCGATCGAGCAGGCCGCGCATCCGGACAAGAGCACGCATGAACGCGACGACCTGCTGACGCTGACGGCCGGGCTCGATCG
CGCGCTGCGCGACGAGATCGTCGCACTGTGGGACGAATACGAGGCGGCGGCCTCATCGGAAGCGCGCGCCGCGAAGGCAC
TCGACAAGCTCGAAACGATCCTCCAGCACAACCAAGGTAGCAATCCGCCGGATTTCGACTACGCGTTCAATCTCGGCTAC
GGCCGGCGCTACACCGACGCGGCGCCGCTGTTCGGCGCGATCCGCGCGATCGTCGACGCGGACACGCAACGCCGGATCGA
CGCTCGCGGCGACGGCACGTAA

Antitoxin

Protein

• Length: 186 a.a.
• Molecular weight: 20340.44 Da
• Isoelectric Point: 10.7102

>AT58647 WP_059819475.1 NZ_CP013428:1854080-1854637 [Burkholderia sp. MSMB0856]
MPASPLHTSPLGPQLKRWRTLHRMKQSHAAELFGVAQSTISRWEAGIQQMSPDERAMAERLLAARLDSAGDHALARLIAS
STARMHLVCDLTHRLLACSPSRAAEFSRPLPMLLGTSLWRYATPEIVRMEAALDPLGWHDRAGPPNVEFATGANASRIVP
IRGSTCRWTRMTLSDGSAARLVETL

Nucleotide

• Length: 558 bp

>AT58647 NZ_CP013428:1854080-1854637 [Burkholderia sp. MSMB0856]
ATGCCCGCCTCACCGCTTCACACCTCGCCGCTCGGCCCGCAACTCAAGCGTTGGCGCACACTGCATCGCATGAAGCAGAG
CCACGCGGCCGAGTTGTTCGGCGTCGCGCAATCGACGATTTCGCGTTGGGAAGCCGGCATCCAGCAGATGTCGCCCGACG
AGCGCGCGATGGCCGAGCGGCTGCTTGCCGCGCGTCTCGATTCGGCCGGCGACCACGCGCTCGCGCGGCTGATCGCGAGC
AGCACGGCGCGCATGCATCTCGTGTGCGATCTCACGCACCGTCTGCTCGCCTGCTCGCCGTCGCGCGCGGCCGAGTTTTC
GCGGCCGCTGCCGATGCTGCTCGGTACATCGCTGTGGCGCTACGCGACGCCGGAAATCGTCCGCATGGAAGCCGCGCTCG
ACCCGCTCGGCTGGCACGATCGCGCGGGGCCGCCGAACGTCGAGTTCGCGACCGGCGCCAATGCGTCGCGCATCGTGCCG
ATCCGCGGCAGCACCTGCCGATGGACGCGGATGACGCTATCGGACGGCTCCGCCGCGCGGCTCGTCGAAACGCTGTAG