Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-RelB
Location 1770837..1771360 Replicon chromosome
Accession NZ_CP013428
Organism Burkholderia sp. MSMB0856

Toxin (Protein)


Gene name relE Uniprot ID B1YYI4
Locus tag WS87_RS25495 Protein ID WP_012366508.1
Coordinates 1771094..1771360 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A102EVI0
Locus tag WS87_RS25490 Protein ID WP_059526792.1
Coordinates 1770837..1771097 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WS87_RS25470 1766944..1768332 + 1389 WP_059819423.1 MFS transporter -
WS87_RS25475 1768681..1769892 + 1212 WP_059819424.1 winged helix-turn-helix domain-containing protein -
WS87_RS25480 1769968..1770186 - 219 WP_006751720.1 DUF1653 domain-containing protein -
WS87_RS25485 1770242..1770685 - 444 WP_059526789.1 GNAT family N-acetyltransferase -
WS87_RS25490 1770837..1771097 + 261 WP_059526792.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
WS87_RS25495 1771094..1771360 + 267 WP_012366508.1 Txe/YoeB family addiction module toxin Toxin
WS87_RS25500 1771391..1771645 - 255 WP_082750669.1 DUF4087 domain-containing protein -
WS87_RS25505 1771652..1772275 + 624 WP_059819697.1 HAD hydrolase-like protein -
WS87_RS25510 1772646..1773218 + 573 WP_059526798.1 DUF4142 domain-containing protein -
WS87_RS25515 1773318..1773923 - 606 WP_059819698.1 GNAT family N-acetyltransferase -
WS87_RS25520 1773985..1774899 - 915 WP_059819426.1 LysR family transcriptional regulator -
WS87_RS25525 1775008..1776246 + 1239 WP_059819427.1 diaminopimelate decarboxylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10468.82 Da        Isoelectric Point: 8.8834

>T58646 WP_012366508.1 NZ_CP013428:1771094-1771360 [Burkholderia sp. MSMB0856]
MSVRRVLFTSDAWDDYVYWQGQDRKTLKRINQLIREAQRTPFEGIGKPEPLKANLSGFWSRRIDDTNRLVYEADDLQISI
VSCRYHYA

Download         Length: 267 bp

>T58646 NZ_CP013428:1771094-1771360 [Burkholderia sp. MSMB0856]
ATGAGCGTACGCCGCGTGCTCTTTACTTCCGACGCGTGGGACGACTACGTTTATTGGCAAGGGCAGGACCGCAAGACACT
CAAGCGCATCAACCAGCTCATTCGCGAAGCCCAACGGACGCCGTTCGAAGGCATCGGCAAACCTGAGCCGCTGAAGGCCA
ATCTGTCCGGGTTCTGGTCGCGCCGCATCGACGATACGAACCGTCTGGTCTATGAAGCGGACGATCTTCAGATCAGCATC
GTGTCCTGCCGCTACCATTACGCGTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9716.99 Da        Isoelectric Point: 6.4814

>AT58646 WP_059526792.1 NZ_CP013428:1770837-1771097 [Burkholderia sp. MSMB0856]
MRTIHFSDARGNLKTVIDQVVDDADVTLITRRDAPNAVIMSQEYYDSLMETVHLLRSPANVAHLERSIAQLRKGKTKEHK
LAGDDE

Download         Length: 261 bp

>AT58646 NZ_CP013428:1770837-1771097 [Burkholderia sp. MSMB0856]
ATGCGCACCATTCACTTTTCGGATGCCCGCGGCAATCTGAAGACGGTCATCGACCAGGTTGTCGACGACGCTGACGTGAC
GCTCATCACTCGTCGCGACGCGCCGAACGCAGTCATCATGTCGCAGGAATACTACGACAGCCTGATGGAGACAGTTCATC
TGCTCCGCTCCCCGGCCAACGTCGCTCATCTCGAACGCTCGATCGCGCAACTGCGCAAGGGCAAGACGAAAGAGCACAAG
CTGGCGGGGGACGATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A102EVD7

Antitoxin

Source ID Structure
AlphaFold DB A0A102EVI0

References