Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1693807..1694462 Replicon chromosome
Accession NZ_CP013428
Organism Burkholderia sp. MSMB0856

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag WS87_RS25195 Protein ID WP_059819393.1
Coordinates 1693807..1694226 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag WS87_RS25200 Protein ID WP_059819394.1
Coordinates 1694223..1694462 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WS87_RS25170 1689330..1690124 + 795 WP_059526657.1 AraC family transcriptional regulator -
WS87_RS25175 1690337..1691260 + 924 WP_059819690.1 DMT family transporter -
WS87_RS25180 1691415..1691963 + 549 WP_059819391.1 hypothetical protein -
WS87_RS25185 1692054..1692188 - 135 WP_059449563.1 entericidin A/B family lipoprotein -
WS87_RS25190 1692423..1693718 + 1296 WP_059819392.1 aspartate carbamoyltransferase -
WS87_RS25195 1693807..1694226 - 420 WP_059819393.1 type II toxin-antitoxin system VapC family toxin Toxin
WS87_RS25200 1694223..1694462 - 240 WP_059819394.1 Arc family DNA-binding protein Antitoxin
WS87_RS25205 1694785..1697028 + 2244 WP_059819395.1 TonB-dependent siderophore receptor -
WS87_RS25210 1697032..1697787 + 756 WP_059819396.1 sel1 repeat family protein -
WS87_RS25215 1697784..1698467 + 684 WP_059819397.1 Fe2+-dependent dioxygenase -
WS87_RS25220 1698838..1699422 + 585 WP_059526676.1 nucleotidyltransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(7-45)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15009.28 Da        Isoelectric Point: 5.8818

>T58645 WP_059819393.1 NZ_CP013428:c1694226-1693807 [Burkholderia sp. MSMB0856]
MILVDTNVISEPLRREPSLAVIEWLDAQNVETLFLAAISLAEMRFGVAALPEGRRRDWLHQSIEQRIVPLFRGRVLPFDD
AASKAYASLRAKARATGNALASADGFIAATAAANGLIVATRDVAPFEAAGLRVIDPWVG

Download         Length: 420 bp

>T58645 NZ_CP013428:c1694226-1693807 [Burkholderia sp. MSMB0856]
ATGATCCTGGTCGATACCAACGTCATTTCCGAGCCGTTGCGACGCGAGCCGAGCTTGGCCGTGATCGAATGGCTCGACGC
GCAGAACGTCGAGACGCTGTTTCTTGCCGCAATCAGTCTCGCGGAAATGCGATTCGGCGTGGCGGCATTGCCCGAAGGGC
GGAGGCGAGACTGGCTGCATCAAAGCATCGAGCAGCGCATCGTGCCGCTGTTTCGCGGCCGGGTCCTGCCGTTCGACGAT
GCAGCCAGCAAAGCGTATGCGAGCCTTCGTGCGAAGGCTCGTGCGACGGGCAACGCGCTGGCATCGGCAGATGGCTTTAT
CGCCGCAACAGCCGCAGCGAACGGTTTGATCGTGGCTACGCGCGACGTCGCGCCGTTCGAAGCGGCGGGCCTGCGCGTGA
TCGACCCGTGGGTCGGCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8731.83 Da        Isoelectric Point: 5.1133

>AT58645 WP_059819394.1 NZ_CP013428:c1694462-1694223 [Burkholderia sp. MSMB0856]
MPVITVRNLPDEVHRALRVRAAQHGRSTEAEVRDILEQAVQPDGRPKLGTLLAEIGREAGGIDFEVRRDGSPTDPMSFE

Download         Length: 240 bp

>AT58645 NZ_CP013428:c1694462-1694223 [Burkholderia sp. MSMB0856]
ATGCCCGTGATCACGGTTCGAAATTTGCCCGACGAGGTGCATCGCGCGCTTCGGGTCCGCGCAGCGCAACATGGCCGCAG
TACCGAAGCCGAGGTGCGCGACATTCTGGAGCAGGCCGTGCAGCCCGACGGGCGGCCCAAGCTGGGCACGCTGCTGGCTG
AAATCGGACGGGAGGCCGGCGGTATCGATTTCGAGGTTCGGCGTGACGGATCGCCCACCGACCCGATGAGCTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References