Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1598288..1600038 Replicon chromosome
Accession NZ_CP013428
Organism Burkholderia sp. MSMB0856

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag WS87_RS24710 Protein ID WP_059819337.1
Coordinates 1599142..1600038 (-) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag WS87_RS24705 Protein ID WP_059819336.1
Coordinates 1598288..1599145 (-) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WS87_RS24685 1593431..1594921 - 1491 WP_059819333.1 aldehyde dehydrogenase -
WS87_RS24690 1595011..1595838 - 828 WP_059819334.1 aspartate dehydrogenase -
WS87_RS24695 1595831..1597501 - 1671 WP_059819335.1 thiamine pyrophosphate-binding protein -
WS87_RS24700 1597494..1598291 - 798 WP_059526445.1 SDR family oxidoreductase -
WS87_RS24705 1598288..1599145 - 858 WP_059819336.1 IclR family transcriptional regulator Antitoxin
WS87_RS24710 1599142..1600038 - 897 WP_059819337.1 alpha/beta fold hydrolase Toxin
WS87_RS24715 1600057..1600584 - 528 WP_059526452.1 cupin domain-containing protein -
WS87_RS24720 1600619..1601389 - 771 WP_059526455.1 SDR family oxidoreductase -
WS87_RS24725 1601382..1602452 - 1071 WP_059819338.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
WS87_RS24730 1602507..1602818 - 312 WP_059526461.1 hypothetical protein -
WS87_RS24735 1602820..1603137 - 318 WP_006758060.1 non-heme iron oxygenase ferredoxin subunit -
WS87_RS24740 1603587..1604666 + 1080 WP_059819339.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-279)

Antitoxin

Transcription regulator IclR, N-terminal

(24-72)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30816.97 Da        Isoelectric Point: 7.1375

>T58644 WP_059819337.1 NZ_CP013428:c1600038-1599142 [Burkholderia sp. MSMB0856]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAQHAGHALPVVLLHGIGSGAASWVRQLDALGASRRVLAW
DAPGYGVSTPVHGASPAAADYAASLNAWLEALGIERCVLVGHSLGAIVAGGLARVMPARIAGLLLISPAGGYGSAPAETR
DTRRDARLAMLEELGPAGLAEQRSGNMLSGFASEDARAWVRWNMARIVPAGYEQATHLLANADLASDLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAVYSSLIDTFCRQCDRQRGLE

Download         Length: 897 bp

>T58644 NZ_CP013428:c1600038-1599142 [Burkholderia sp. MSMB0856]
ATGAGTGTCATCGACAAACGTGAACGCGACCGCACCGCGGCGTTCGCCGCGCTGCTCGGGCAGTTTCCCGAACAGCGCTG
CGCGGCCGGCGCGGCGGGCACGATCGGTTATCGCGAGGCCGGCGCGCAACATGCGGGCCACGCGCTGCCCGTCGTGCTGC
TGCACGGGATCGGCTCGGGCGCCGCATCGTGGGTGCGCCAGCTCGACGCGCTCGGCGCGTCGCGGCGCGTGCTCGCGTGG
GATGCGCCCGGCTACGGCGTGTCGACGCCCGTGCACGGCGCGTCGCCGGCGGCCGCCGATTACGCGGCGTCGCTGAACGC
GTGGCTCGAGGCACTCGGCATCGAACGCTGCGTGCTGGTCGGGCATTCGCTCGGTGCGATCGTCGCGGGCGGGTTGGCCC
GCGTGATGCCCGCGCGGATCGCCGGCCTGCTGCTGATCTCGCCCGCGGGCGGTTACGGCAGCGCGCCCGCGGAAACGCGC
GACACGCGCCGCGATGCACGCCTTGCCATGCTCGAGGAACTCGGCCCGGCCGGGCTCGCCGAGCAACGCAGCGGCAACAT
GCTGTCGGGATTCGCGAGCGAGGATGCGCGCGCGTGGGTGCGCTGGAACATGGCGCGTATCGTGCCGGCCGGCTATGAGC
AGGCCACGCATCTGCTCGCGAACGCCGATCTCGCGTCCGATCTCGCCGGCTTTCGCGGCCGCACCGCGGTGGCGGTCGGC
GCGAACGACGCGATCACGCCGCCTGCCGCGTGCGAGCGCATCGCGGCCGCCGCGCACGTCGGGTTGCAGGTGATTCCGCA
GGCCGGTCATGCGGGTTACGTGGAAGCACCGGCGGTTTATTCGTCGCTGATCGACACGTTCTGCCGTCAATGCGATCGCC
AACGGGGGCTGGAATGA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31336.80 Da        Isoelectric Point: 6.6549

>AT58644 WP_059819336.1 NZ_CP013428:c1599145-1598288 [Burkholderia sp. MSMB0856]
MSEPLQQQDADAAKSEANYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQSPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLQALRALYPEGTLNRMTSATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNDTQRIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFMKALGLR

Download         Length: 858 bp

>AT58644 NZ_CP013428:c1599145-1598288 [Burkholderia sp. MSMB0856]
ATGAGCGAACCGTTGCAACAACAGGATGCGGACGCCGCGAAGTCCGAGGCCAACTACGTGGTGCCGGGCCTCGAACGCGG
TTTGCGAATCCTCGCCGAATTTTCGCCGCGCGAGCCGGTGCTCGGCGCGCCGGAGTTGTCCAAGCGGCTCGGCATTCCGC
GCACGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGCTTTCTCGAGCGCGCGGACAAGGACCGCAACTACAAG
CTCGGCATCGCCGTGCTGCGGCTCGGCTTCGAATACCTGAGCTCGCTCGAGCTGACCGATCTCGGCCTGCCGGTGATCGA
GAGCCTGCGCGACGCGACCGGCTTCACGACGCACATCGTGATCCGCGACGGCCGCGACGTGGTGTTCGTCGCGAAAGCGC
AGAGCCAGTCGCCGGTGTTCAGCTCGATTCGCGTGAACGTCGGCACGCGGCTGCCCGCGCATGCGACGACCCACGGCCAC
GTGCTGATGGGCGATCTGTCGCTTCAGGCGCTGCGCGCGCTGTATCCGGAAGGCACGCTGAACCGGATGACGAGCGCGAC
GCCGGAGACGGTCGATGCGCTGTACGAAGTGATCCGCGAGGATGCGCTGCGCGGCTACGGCGTCAGCAATTCGTCGTTCG
AACGCGGCATTTCGGTGGTCACGGCGCCGGTGCGCAACGACACGCAGCGGATCGTCGCGTGCATCACGGTGACGGTGCCT
CGGCCGGAGATCGACGCGGCGCTGATCGCCGACGGCCTGATCGACAAGGTGCAGCGCGCGGCGGCGGAACTGTCGCGGCG
GCTCAATTACCGCTCGGATGACGAGCACACGTTTATGAAGGCTTTAGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References