Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1937890..1939667 Replicon chromosome
Accession NZ_CP013425
Organism Burkholderia sp. MSMB0852

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag WS86_RS29095 Protein ID WP_059647526.1
Coordinates 1938315..1939667 (+) Length 451 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag WS86_RS29090 Protein ID WP_059647523.1
Coordinates 1937890..1938318 (+) Length 143 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WS86_RS29060 1933332..1934183 - 852 WP_059647518.1 ABC transporter permease subunit -
WS86_RS29065 1934186..1934968 - 783 WP_059576046.1 ATP-binding cassette domain-containing protein -
WS86_RS29070 1934989..1935999 - 1011 WP_059647520.1 taurine ABC transporter substrate-binding protein -
WS86_RS29075 1935995..1936210 + 216 Protein_1608 hypothetical protein -
WS86_RS29080 1936363..1937199 + 837 WP_059647522.1 taurine dioxygenase -
WS86_RS29090 1937890..1938318 + 429 WP_059647523.1 helix-turn-helix domain-containing protein Antitoxin
WS86_RS29095 1938315..1939667 + 1353 WP_059647526.1 type II toxin-antitoxin system HipA family toxin Toxin
WS86_RS29100 1940012..1940455 - 444 WP_059576055.1 hypothetical protein -
WS86_RS29110 1940742..1941656 - 915 WP_059576058.1 LysR family transcriptional regulator -
WS86_RS29115 1941809..1942765 + 957 WP_059647528.1 agmatinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(158-403)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-71)


Sequences

Toxin        


Download         Length: 451 a.a.        Molecular weight: 50027.00 Da        Isoelectric Point: 8.4888

>T58641 WP_059647526.1 NZ_CP013425:1938315-1939667 [Burkholderia sp. MSMB0852]
VSARRARATRLHLWMNGLPVGYWEHARDGERLVYFDEWIADPQGRPLSLSLPFTPGNQPYRGRLVSDYFDNLLPDSEPIR
RRIAMRYRTGGTSPFELLATLGRDCVGALQMLPPDEAPDDLERIRGRALADADIARLLRDITSAPQAGQHEPLDDLRLSI
AGAQEKTALLRHRGRWLLPDGSTPTTHILKLPLGLVGNRRADMRTSVENEWLCSKIVAAYGLPVAHCDIAHFDEQKALVV
ERFDRRPSSDARWILRLPQEDMCQATGTSALDKYQADGGPGIEAIMDVLAGSEHAGDRHAFFASQIVFWLLAATDGHAKN
FSIAHLPGNRYRSTPLYDVLSAHPVIGRGANRLPAQRVRLAMGVRGKHVHYLIHQIQRRHWIAQGQRVGFAPAEVDDMID
ALTVRTAGVIDEVSARLPRDFPMDVADATFSGMLRLNAKLAAETAARASR

Download         Length: 1353 bp

>T58641 NZ_CP013425:1938315-1939667 [Burkholderia sp. MSMB0852]
GTGAGCGCCCGCCGCGCGCGCGCCACGCGCCTGCATCTGTGGATGAACGGCCTGCCCGTCGGCTATTGGGAGCATGCGCG
CGACGGCGAGCGCCTCGTCTACTTCGACGAATGGATCGCCGATCCGCAGGGCCGCCCGCTATCGCTGTCGTTGCCGTTCA
CGCCGGGCAACCAGCCGTATCGCGGCCGGCTCGTCAGCGACTACTTCGACAACCTGCTGCCCGACAGCGAACCGATCCGG
CGCCGCATCGCGATGCGCTACAGGACGGGCGGCACGTCGCCGTTCGAGCTGCTCGCGACGCTCGGCCGCGATTGCGTCGG
CGCGCTGCAGATGCTGCCGCCCGACGAAGCGCCGGACGATCTCGAACGCATCCGCGGCCGCGCGCTCGCCGATGCGGACA
TCGCTCGGCTGCTGCGCGACATCACGTCCGCGCCGCAAGCCGGGCAGCACGAGCCGCTCGACGATCTGCGCCTGTCGATC
GCGGGCGCGCAGGAAAAGACCGCGCTGCTACGCCATCGCGGCCGCTGGCTGCTGCCCGACGGCAGCACGCCGACCACGCA
TATCCTGAAGCTGCCGCTCGGGCTCGTCGGCAACCGGCGCGCCGACATGCGCACGTCGGTCGAAAACGAATGGCTGTGCT
CGAAGATCGTCGCCGCGTACGGATTGCCGGTCGCGCATTGCGACATCGCGCACTTCGACGAGCAGAAGGCGCTCGTCGTC
GAGCGCTTCGACCGCAGGCCGTCGAGCGACGCGCGCTGGATTCTGCGCCTGCCGCAGGAAGACATGTGCCAGGCGACGGG
CACGTCCGCGCTCGACAAATATCAGGCCGACGGCGGGCCCGGCATCGAGGCGATCATGGACGTGCTCGCCGGCTCCGAGC
ACGCGGGCGACCGCCACGCGTTCTTCGCGTCGCAGATCGTGTTCTGGCTGCTCGCCGCGACCGACGGCCACGCGAAGAAT
TTCAGCATCGCGCATCTGCCCGGCAACCGCTATCGATCGACGCCGTTATACGACGTGCTGTCCGCGCATCCGGTGATCGG
CCGGGGGGCGAACCGCTTGCCGGCGCAGCGCGTGCGGCTCGCGATGGGCGTGCGCGGCAAGCACGTCCATTACCTGATCC
ATCAGATCCAGCGGCGGCACTGGATCGCGCAGGGCCAGCGCGTCGGCTTCGCGCCCGCCGAGGTCGACGACATGATCGAC
GCGTTGACCGTGCGCACCGCGGGCGTCATCGACGAAGTGTCGGCCCGGCTGCCGCGCGATTTTCCGATGGACGTCGCCGA
TGCGACCTTCAGCGGGATGCTGCGCCTGAATGCGAAGCTCGCGGCCGAAACGGCGGCGCGGGCCTCGCGATGA

Antitoxin


Download         Length: 143 a.a.        Molecular weight: 15471.01 Da        Isoelectric Point: 12.0874

>AT58641 WP_059647523.1 NZ_CP013425:1937890-1938318 [Burkholderia sp. MSMB0852]
MAITIEHEIKTLDQLRPILRGFRKVAGLTQAMVASRLGVTQQTYAQFEANPASASVERLFKVLRVLNVELTLTYIHTASA
RPAAKQAIALPARKAAQASGSGRVAAKRPAPPASQSMPAPRAAERQPRPARKRAAPKKREDW

Download         Length: 429 bp

>AT58641 NZ_CP013425:1937890-1938318 [Burkholderia sp. MSMB0852]
ATGGCCATCACCATCGAACACGAGATCAAGACGCTCGACCAACTGCGGCCCATCCTGCGCGGCTTCCGCAAGGTGGCCGG
GTTGACGCAGGCGATGGTCGCGAGCCGCCTCGGCGTCACGCAGCAGACGTATGCGCAATTCGAGGCGAATCCGGCGTCGG
CGAGCGTCGAGCGGCTGTTCAAGGTGCTGCGCGTTCTCAACGTCGAGCTCACGCTCACCTACATCCACACCGCTTCCGCC
AGGCCCGCCGCGAAGCAAGCCATCGCCTTGCCCGCGCGCAAGGCCGCGCAGGCTTCCGGAAGCGGGCGCGTCGCCGCCAA
ACGCCCGGCGCCGCCCGCGAGCCAATCGATGCCCGCCCCGCGCGCCGCCGAGCGCCAGCCCCGCCCCGCGCGCAAGCGCG
CCGCCCCGAAGAAGCGGGAGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References