Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1386506..1387161 Replicon chromosome
Accession NZ_CP013425
Organism Burkholderia sp. MSMB0852

Toxin (Protein)


Gene name relE Uniprot ID A0A0F6LEW6
Locus tag WS86_RS26505 Protein ID WP_006027262.1
Coordinates 1386865..1387161 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q63YL3
Locus tag WS86_RS26500 Protein ID WP_004202809.1
Coordinates 1386506..1386862 (-) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WS86_RS26480 1381641..1382654 - 1014 WP_059641249.1 phage major capsid protein, P2 family -
WS86_RS26485 1382688..1383497 - 810 WP_059641246.1 GPO family capsid scaffolding protein -
WS86_RS26490 1383641..1385410 + 1770 WP_059641344.1 terminase ATPase subunit family protein -
WS86_RS26495 1385407..1386462 + 1056 WP_059641244.1 phage portal protein -
WS86_RS26500 1386506..1386862 - 357 WP_004202809.1 putative addiction module antidote protein Antitoxin
WS86_RS26505 1386865..1387161 - 297 WP_006027262.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WS86_RS26510 1387807..1388922 - 1116 WP_059641242.1 DUF3396 domain-containing protein -
WS86_RS26515 1388937..1389674 - 738 WP_059641239.1 VRR-NUC domain-containing protein -
WS86_RS26520 1389671..1390204 - 534 WP_006027265.1 PAAR domain-containing protein -
WS86_RS26525 1390307..1390429 - 123 WP_009914987.1 hypothetical protein -
WS86_RS26530 1390663..1391316 - 654 WP_009914986.1 AAA family ATPase -
WS86_RS26535 1391406..1391612 - 207 WP_004532731.1 ogr/Delta-like zinc finger family protein -
WS86_RS26540 1391609..1391875 - 267 WP_059641237.1 ogr/Delta-like zinc finger family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1362870..1422670 59800


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Uncharacterized protein HI1420

(16-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10844.65 Da        Isoelectric Point: 10.1723

>T58640 WP_006027262.1 NZ_CP013425:c1387161-1386865 [Burkholderia sp. MSMB0852]
MFKVLTTPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRRGKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED

Download         Length: 297 bp

>T58640 NZ_CP013425:c1387161-1386865 [Burkholderia sp. MSMB0852]
ATGTTCAAAGTTCTGACGACCCCCCAGTTTGACAAATGGCTCGACGGGCTTCGCGACCCGGTCGGTAGCGCGGCGATCAA
CCTGCGCATCGAGCGGGCAAAGCTTGGCAATCTCGGCCAATGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTACTTCGTGCGACGCGGAAAAATTATCGTCGTGGTGTTGTGCGGCGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCCGGCGAACTGGAGGATTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12585.41 Da        Isoelectric Point: 9.9470

>AT58640 WP_004202809.1 NZ_CP013425:c1386862-1386506 [Burkholderia sp. MSMB0852]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA

Download         Length: 357 bp

>AT58640 NZ_CP013425:c1386862-1386506 [Burkholderia sp. MSMB0852]
ATGAAAATCAGCGAACTGGCCGAGTTCGACGGCTCGAAGTACCTGAAGGACGAGGAAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAATCCGCGCCTGATTCAAGCCGCGCTTGGGAACGTTGCGAAGGCGCGCGGCATGACGGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTACCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTTGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAACCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTACGCACGGCTGCGCACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F6LEW6

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4G1D3

References