Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1146113..1147860 Replicon chromosome
Accession NZ_CP013425
Organism Burkholderia sp. MSMB0852

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag WS86_RS25290 Protein ID WP_059646723.1
Coordinates 1146113..1147009 (+) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1B4SHD2
Locus tag WS86_RS25295 Protein ID WP_038744096.1
Coordinates 1147006..1147860 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WS86_RS25255 1141515..1142603 - 1089 WP_038744082.1 porin -
WS86_RS25265 1143038..1143355 + 318 WP_038744084.1 non-heme iron oxygenase ferredoxin subunit -
WS86_RS25270 1143357..1143668 + 312 WP_038744087.1 hypothetical protein -
WS86_RS25275 1143703..1144770 + 1068 WP_038744090.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
WS86_RS25280 1144767..1145537 + 771 WP_059646725.1 SDR family oxidoreductase -
WS86_RS25285 1145569..1146096 + 528 WP_038744200.1 cupin domain-containing protein -
WS86_RS25290 1146113..1147009 + 897 WP_059646723.1 alpha/beta fold hydrolase Toxin
WS86_RS25295 1147006..1147860 + 855 WP_038744096.1 IclR family transcriptional regulator Antitoxin
WS86_RS25300 1147857..1148654 + 798 WP_059646721.1 SDR family oxidoreductase -
WS86_RS25305 1148647..1150320 + 1674 WP_059582509.1 thiamine pyrophosphate-binding protein -
WS86_RS25310 1150313..1151128 + 816 WP_038744102.1 aspartate dehydrogenase -
WS86_RS25315 1151150..1152640 + 1491 WP_059582508.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-281)

Antitoxin

Transcription regulator IclR, C-terminal

(143-265)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30415.37 Da        Isoelectric Point: 7.6841

>T58639 WP_059646723.1 NZ_CP013425:1146113-1147009 [Burkholderia sp. MSMB0852]
MSAISRPAGDASAKPFAELLGCFAERRADAGAAGTIGYREAGDAHGERCPVVLLHGIGSGAASWVRQLDALGATRRVLAW
DAPGYGASSRVAADSPVAADYAAALGAWLDALRIGRCVLVGHSLGAIVAGAFARRAGERLSGLLLISPAGGYGSAPADVR
AERRDSRLALLAALGPQGLADERSANMLSAYASDAARAWVRWNMARIVPAGYAQATHLLANADLASDLSHYHGRIAVAAG
ANDAITPPAACERIAQAAGVGLQVIPRVGHAGYVEAPDAYSALIDAFCRQCDGSRGAP

Download         Length: 897 bp

>T58639 NZ_CP013425:1146113-1147009 [Burkholderia sp. MSMB0852]
ATGAGCGCAATTTCCAGGCCGGCTGGCGACGCCAGCGCGAAACCGTTCGCGGAGCTGCTCGGCTGCTTTGCCGAGCGCCG
CGCGGACGCGGGCGCCGCGGGCACGATCGGCTACCGCGAGGCGGGCGACGCGCACGGCGAGCGCTGTCCCGTCGTGTTGC
TGCACGGGATCGGATCGGGCGCGGCGTCGTGGGTGCGTCAACTCGATGCGCTCGGCGCGACGCGCCGCGTGCTCGCGTGG
GATGCGCCCGGCTATGGTGCTTCGTCGCGCGTCGCGGCCGATTCGCCCGTCGCGGCCGATTACGCGGCGGCGCTCGGCGC
ATGGCTCGATGCGTTGCGGATCGGGCGCTGCGTGCTTGTCGGCCATTCGCTCGGCGCGATCGTCGCGGGCGCGTTCGCGC
GGCGCGCGGGCGAGCGTCTGTCAGGATTGCTGCTGATTTCACCCGCGGGCGGCTACGGCAGCGCGCCCGCCGACGTGCGC
GCCGAGCGGCGCGACAGCCGGCTCGCGCTGCTCGCGGCGCTCGGCCCGCAAGGGCTCGCCGACGAGCGCAGCGCGAACAT
GCTGTCCGCGTACGCGAGCGACGCGGCGCGCGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGCCCGCGGGCTATGCGC
AGGCGACGCACCTGCTCGCGAACGCGGACCTCGCGTCCGATCTTTCGCATTATCACGGCCGCATCGCGGTCGCGGCCGGC
GCGAACGACGCGATCACGCCGCCCGCCGCATGCGAGCGGATCGCACAGGCGGCGGGCGTCGGGTTGCAGGTGATTCCGCG
CGTGGGCCACGCGGGCTATGTCGAAGCGCCCGATGCGTACAGCGCGTTGATCGACGCATTTTGCCGTCAATGCGACGGAT
CGCGAGGTGCGCCATGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31263.70 Da        Isoelectric Point: 6.6619

>AT58639 WP_038744096.1 NZ_CP013425:1147006-1147860 [Burkholderia sp. MSMB0852]
MSEPLLKDADDAKNDSNYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYRL
GVAVLRLGFEYLSSLELTDLGLPVIEGLRDATGFTTHIVIRDGRDVVFVAKAQNAGHAFGSVRVNVGTRLPAHATTHGHV
LMGDLSLAELRALYPERELERVTKATPETLDALFDVIRDDARRGYGIGNSAFERDISVVTAPVRNDARKIVAVVTVTVPR
PEIDASLVADGLIDKVLRAAAELSRRLNYRSDDENTYLKALGLR

Download         Length: 855 bp

>AT58639 NZ_CP013425:1147006-1147860 [Burkholderia sp. MSMB0852]
ATGAGCGAGCCGCTGCTGAAAGACGCCGACGACGCGAAGAATGATTCGAACTACGTAGTACCTGGGCTCGAGCGCGGGCT
GCGGATTCTCGCCGAATTCTCGCCGCGCGAGCCGGTGCTCGGTGCGCCCGAGCTGTCGAAGCGGCTCGGCATCCCGCGCA
CGACGGTGTTCCGCTTGCTGCAGACGCTCGAATCGCTCGGCTTTCTCGAGCGCGCGGACAAGGATCGCAACTATCGCCTC
GGGGTTGCGGTGCTGCGCCTCGGCTTCGAGTATCTGAGCTCGCTCGAGCTGACCGATCTCGGCTTGCCGGTGATCGAAGG
GCTGCGCGACGCGACGGGCTTCACGACGCACATCGTGATCCGCGACGGCCGCGACGTCGTGTTCGTCGCGAAGGCGCAGA
ACGCGGGGCATGCGTTCGGCTCGGTGCGGGTGAACGTCGGCACGCGCCTGCCCGCGCATGCGACGACGCACGGTCACGTG
CTGATGGGCGACCTGTCGCTCGCCGAGTTGCGCGCGCTGTACCCCGAACGGGAGCTCGAGCGCGTGACGAAGGCGACGCC
GGAAACCCTCGACGCGCTCTTCGACGTGATTCGCGACGACGCGCGCCGCGGCTACGGGATCGGCAATTCGGCGTTCGAGC
GCGACATCTCGGTCGTCACCGCGCCCGTGCGCAACGACGCGAGGAAGATCGTCGCGGTCGTCACGGTGACGGTGCCGAGG
CCCGAGATCGACGCATCGCTCGTCGCCGACGGGCTGATCGACAAGGTGCTGCGCGCGGCGGCGGAGTTGTCGCGGCGGCT
CAACTACCGTTCCGACGACGAAAACACCTATTTGAAGGCTTTGGGATTGCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1B4SHD2

References