Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 470957..472677 Replicon chromosome
Accession NZ_CP013424
Organism Burkholderia sp. MSMB0852

Toxin (Protein)


Gene name pmenT Uniprot ID -
Locus tag WS86_RS02805 Protein ID WP_059642481.1
Coordinates 470957..471601 (+) Length 215 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID -
Locus tag WS86_RS02810 Protein ID WP_043277117.1
Coordinates 471601..472677 (+) Length 359 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WS86_RS02770 466204..467586 + 1383 WP_059577328.1 cytochrome bc complex cytochrome b subunit -
WS86_RS02775 467608..468366 + 759 WP_038754985.1 cytochrome c1 -
WS86_RS02780 468460..469071 + 612 WP_004185176.1 glutathione S-transferase N-terminal domain-containing protein -
WS86_RS02785 469141..469674 + 534 WP_038754999.1 ClpXP protease specificity-enhancing factor -
WS86_RS33910 469996..470301 + 306 WP_157131023.1 helix-turn-helix domain-containing protein -
WS86_RS02800 470388..470957 + 570 WP_082744982.1 DUF4433 domain-containing protein -
WS86_RS02805 470957..471601 + 645 WP_059642481.1 DUF4433 domain-containing protein Toxin
WS86_RS02810 471601..472677 + 1077 WP_043277117.1 macro domain-containing protein Antitoxin
WS86_RS02815 473058..473234 + 177 Protein_440 DUF4102 domain-containing protein -
WS86_RS02820 473309..474739 - 1431 WP_059642506.1 diguanylate cyclase -
WS86_RS02825 475390..475683 - 294 WP_082744981.1 phage virion morphogenesis protein -
WS86_RS02830 475806..476426 + 621 Protein_443 transposase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 470957..479754 8797


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(14-214)

Antitoxin

Macro domain

(18-130)


Sequences

Toxin        


Download         Length: 215 a.a.        Molecular weight: 24887.60 Da        Isoelectric Point: 7.5391

>T58638 WP_059642481.1 NZ_CP013424:470957-471601 [Burkholderia sp. MSMB0852]
MLYTSLNPEKALIWRIVHRDNLPWILDNGLYCGNSAVKAPAWVNIGNPELIDKRAHHPVPLPPRGLLNDYVPFYFTPFSP
MLRNIHTGWGGIQKRPNEEIVILVSSLHHIAGLGLPFLFTDSHAYYRWADYYSDLAYLDKIDWPLLQRRDFKRDPDDPAK
FERYQAEALIHQHLPVGGLLGIVCYTEPLKQRIEQEIQARNLNLPVYARTGWYF

Download         Length: 645 bp

>T58638 NZ_CP013424:470957-471601 [Burkholderia sp. MSMB0852]
ATGCTCTATACCAGCCTTAATCCGGAAAAAGCACTGATCTGGCGGATTGTCCACCGCGACAATCTGCCGTGGATTCTGGA
CAATGGCCTGTATTGCGGCAACAGCGCGGTGAAGGCGCCGGCATGGGTGAATATCGGTAACCCGGAGCTTATCGACAAGC
GCGCCCATCATCCGGTGCCGTTGCCGCCGCGCGGCTTGCTGAATGACTATGTACCGTTCTATTTCACGCCCTTCTCGCCG
ATGCTGCGTAACATTCACACCGGATGGGGCGGAATCCAGAAGCGGCCGAATGAAGAAATCGTGATCTTAGTGTCTAGCCT
ACACCACATTGCAGGGTTGGGCTTGCCGTTTTTGTTTACTGACAGTCATGCCTATTATCGTTGGGCAGATTACTACTCGG
ACTTGGCCTACCTCGATAAGATCGACTGGCCTTTGCTACAGCGAAGGGATTTCAAGCGTGACCCGGACGACCCCGCCAAG
TTCGAGCGCTATCAGGCGGAGGCGCTGATTCACCAACACTTGCCAGTGGGCGGACTTCTCGGCATCGTGTGCTATACGGA
ACCTTTGAAACAACGCATCGAACAGGAGATTCAGGCCCGTAATCTGAACCTGCCGGTTTATGCCCGAACAGGGTGGTACT
TCTGA

Antitoxin


Download         Length: 359 a.a.        Molecular weight: 40570.56 Da        Isoelectric Point: 6.0092

>AT58638 WP_043277117.1 NZ_CP013424:471601-472677 [Burkholderia sp. MSMB0852]
MITFTQGNLLEARTEALVNTVNTVGVMGKGIALMFKERFDENFRRYAAACKAKEVQTGKMFVTPVHELDGPRWIVNFPTK
QHWRAPSRMEWVVEGLQDLRRFLIEQQVQSIAIPPLGAGNGGLEWADVREQIELALGDLDIDIVVFEPTKQYQNVAKRAG
VEKLTPARALIAELVRRYWVLGMECSLLEIQKLAWFLERAIERFNPGENPLNLQFAPHKYGPYANRLDHLLNNLDGSYLH
SEKRIGDANPLDVIWFDDERKAFVQTYLKSEAKAYTQALEFTAALIDGFESPFGMELLATVDWLLTREGVAPNVPALREG
LRHWRGGPDAATRKDRLFDDRALGIALERLTQPATALV

Download         Length: 1077 bp

>AT58638 NZ_CP013424:471601-472677 [Burkholderia sp. MSMB0852]
ATGATTACATTCACTCAAGGCAATTTGTTGGAGGCCCGCACTGAGGCGCTGGTCAACACCGTCAACACCGTCGGGGTGAT
GGGCAAGGGCATCGCGCTGATGTTCAAGGAACGCTTTGATGAGAACTTCCGCCGCTATGCCGCCGCCTGCAAAGCGAAGG
AAGTGCAGACAGGCAAGATGTTTGTGACGCCGGTGCACGAACTCGATGGGCCGCGCTGGATCGTTAATTTCCCTACCAAG
CAGCACTGGCGTGCGCCCTCGCGCATGGAGTGGGTGGTGGAAGGCTTGCAGGACCTGCGGCGCTTCTTGATCGAGCAACA
GGTTCAATCCATCGCTATCCCGCCGCTGGGTGCGGGTAACGGTGGCCTGGAATGGGCTGATGTGCGTGAGCAGATCGAAC
TGGCGTTGGGCGATCTGGACATCGACATTGTGGTGTTCGAGCCCACCAAGCAATACCAGAACGTCGCCAAGCGTGCTGGC
GTAGAAAAGCTGACGCCCGCCCGAGCGCTGATCGCCGAATTGGTGCGCCGGTACTGGGTGCTGGGCATGGAATGCAGCTT
GCTGGAGATCCAGAAGCTGGCGTGGTTTCTGGAACGCGCCATTGAGCGTTTCAACCCAGGTGAAAACCCGCTGAACTTGC
AGTTTGCACCACACAAATACGGTCCCTACGCCAACCGACTTGACCACCTGCTGAACAATCTGGATGGCAGCTACCTGCAC
TCTGAAAAGCGCATCGGCGATGCCAATCCGCTGGACGTGATTTGGTTCGACGACGAACGCAAGGCTTTTGTTCAGACATA
TCTCAAGAGCGAAGCCAAGGCCTACACGCAAGCTCTTGAATTCACGGCGGCACTGATCGATGGCTTTGAATCACCCTTTG
GCATGGAACTGCTGGCGACCGTGGATTGGTTGCTGACCCGTGAAGGCGTGGCACCCAACGTGCCGGCCTTGCGCGAAGGG
CTCCGTCATTGGCGCGGTGGTCCAGATGCTGCCACCCGTAAGGACCGCCTTTTTGATGATCGGGCACTGGGCATCGCCCT
GGAGCGTCTGACACAGCCTGCGACAGCGCTGGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References