Detailed information of TA system TA058637

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 292343..292899
• Replicon: chromosome
• Accession: NZ_CP013424
• Organism: Burkholderia sp. MSMB0852

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: WS86_RS01870
• Protein ID: WP_059645511.1
• Coordinates: 292343..292633 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A8A8D2B6
• Locus tag: WS86_RS01875
• Protein ID: WP_025369732.1
• Coordinates: 292621..292899 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WS86_RS01845	288042..288359	+	318	WP_059645503.1	hypothetical protein	-
WS86_RS01850	288317..288928	+	612	WP_059645505.1	hypothetical protein	-
WS86_RS01855	288925..291102	+	2178	WP_059645508.1	DotA/TraY family protein	-
WS86_RS01860	291114..291629	+	516	WP_034188049.1	hypothetical protein	-
WS86_RS33890	291716..291958	-	243	WP_157130942.1	hypothetical protein	-
WS86_RS01865	292038..292346	-	309	WP_157130943.1	hypothetical protein	-
WS86_RS01870	292343..292633	-	291	WP_059645511.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
WS86_RS01875	292621..292899	-	279	WP_025369732.1	CopG family ribbon-helix-helix protein	Antitoxin
WS86_RS01880	293006..294154	-	1149	WP_157130944.1	hypothetical protein	-
WS86_RS01885	294324..294593	-	270	WP_025369734.1	mobilization protein	-
WS86_RS01890	295157..295417	+	261	WP_025369735.1	hypothetical protein	-
WS86_RS01895	295482..296489	-	1008	WP_059645517.1	DUF4917 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	288042..302559	14517

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10853.40 Da
• Isoelectric Point: 9.5564

>T58637 WP_059645511.1 NZ_CP013424:c292633-292343 [Burkholderia sp. MSMB0852]
MPQVIFAPAAVRDLQRLRDFLLPKNPDAARRAGEAIRQGVQALGTHPRMGRLVEDLPAHYREWPIDFGDSGYVARYRLDG
ETVTILAVRHQKEAGY

Nucleotide

• Length: 291 bp

>T58637 NZ_CP013424:c292633-292343 [Burkholderia sp. MSMB0852]
ATGCCGCAAGTGATCTTTGCGCCGGCGGCAGTCCGAGACTTGCAACGGTTGCGCGACTTCCTGCTCCCGAAGAACCCTGA
CGCCGCGAGGCGGGCCGGCGAAGCGATTAGACAAGGCGTACAGGCTCTCGGCACTCACCCCCGAATGGGGCGTCTTGTAG
AAGATCTACCCGCGCATTATCGGGAGTGGCCCATCGATTTCGGGGACAGTGGTTACGTGGCCCGGTACCGCCTCGATGGC
GAAACCGTTACGATCTTGGCCGTCCGACATCAGAAGGAAGCGGGGTATTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10820.15 Da
• Isoelectric Point: 5.2484

>AT58637 WP_025369732.1 NZ_CP013424:c292899-292621 [Burkholderia sp. MSMB0852]
MVTATSIKLDDELKGRVQHLAEARRRTPHWIMREAIEQYVEREEKRETLNKDTLKAWDEFQATGLHATAEEVDKWLASWG
TENELPTPECRK

Nucleotide

• Length: 279 bp

>AT58637 NZ_CP013424:c292899-292621 [Burkholderia sp. MSMB0852]
ATGGTAACAGCGACATCCATCAAGCTCGATGATGAACTGAAAGGGCGGGTACAGCACTTGGCTGAAGCGCGTCGGCGAAC
CCCGCACTGGATCATGCGCGAAGCCATCGAGCAGTACGTCGAGCGCGAGGAAAAGCGGGAGACGTTGAACAAGGACACAC
TCAAGGCGTGGGATGAGTTTCAGGCGACAGGTCTACACGCGACCGCTGAAGAAGTGGATAAGTGGCTCGCGAGCTGGGGG
ACTGAAAACGAGCTGCCCACGCCAGAATGCCGCAAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A8A8D2B6