58635

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 454595..455236 Replicon chromosome
Accession NZ_CP013422
Organism Burkholderia ubonensis strain MSMB0783

Toxin (Protein)


Gene name relE Uniprot ID A0A1B4LKP8
Locus tag WJ35_RS21975 Protein ID WP_069239999.1
Coordinates 454898..455236 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1B4LKT2
Locus tag WJ35_RS21970 Protein ID WP_069239998.1
Coordinates 454595..454894 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WJ35_RS21945 449710..450981 + 1272 WP_060233752.1 Rieske 2Fe-2S domain-containing protein -
WJ35_RS21950 450996..451472 + 477 WP_010089037.1 aromatic-ring-hydroxylating dioxygenase subunit beta -
WJ35_RS21955 451492..451818 + 327 WP_045564530.1 non-heme iron oxygenase ferredoxin subunit -
WJ35_RS21960 451808..453028 + 1221 WP_069239996.1 FAD-dependent oxidoreductase -
WJ35_RS31510 453063..453227 + 165 WP_155121956.1 hypothetical protein -
WJ35_RS21965 453217..454503 + 1287 WP_069239997.1 DUF445 domain-containing protein -
WJ35_RS21970 454595..454894 - 300 WP_069239998.1 putative addiction module antidote protein Antitoxin
WJ35_RS21975 454898..455236 - 339 WP_069239999.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WJ35_RS21980 455593..457233 + 1641 WP_060233758.1 acetolactate synthase large subunit -
WJ35_RS21985 457263..458696 + 1434 WP_060233760.1 aldehyde dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(26-98)

Antitoxin

Uncharacterized protein HI1420

(5-93)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12475.06 Da        Isoelectric Point: 7.2760

>T58635 WP_069239999.1 NZ_CP013422:c455236-454898 [Burkholderia ubonensis]
MVDISSNVPYSAPTSSIRTTEVFDTWFAGLQDRVARRRIQARIDRLATGNPGDWKSVGAPVVEMRIDHGPGYRVYYVQRG
SAWVILLCGGDKSTQQADIRAAHAMLEHLDTE

Download         Length: 339 bp

>T58635 NZ_CP013422:c455236-454898 [Burkholderia ubonensis]
ATGGTTGACATATCGAGTAACGTGCCTTACAGTGCTCCGACGTCCAGCATCAGAACGACCGAAGTCTTCGACACATGGTT
CGCCGGTCTGCAGGATCGCGTCGCACGGCGGCGTATCCAGGCGCGCATCGACCGGCTGGCGACGGGCAATCCGGGCGACT
GGAAGTCCGTCGGCGCGCCGGTCGTCGAAATGCGCATCGACCACGGCCCGGGGTATCGCGTCTACTACGTGCAGCGGGGA
TCGGCTTGGGTGATCCTGCTTTGCGGCGGCGACAAGTCGACGCAACAGGCGGACATACGCGCCGCGCACGCGATGCTCGA
GCATCTCGATACGGAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10721.21 Da        Isoelectric Point: 6.8702

>AT58635 WP_069239998.1 NZ_CP013422:c454894-454595 [Burkholderia ubonensis]
MDKIKTRPWDSAEHLKTEDDMAEYFEACLQEAGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKARA

Download         Length: 300 bp

>AT58635 NZ_CP013422:c454894-454595 [Burkholderia ubonensis]
ATGGACAAGATCAAGACCCGGCCATGGGATTCGGCCGAACACCTGAAGACCGAAGACGACATGGCCGAATACTTCGAAGC
CTGTCTGCAGGAGGCTGGCGACGACCCGGCCTTCATCGCGCACGCGCTCGGCGTGATCGCGCGTGCGCGCGGCATGTCGC
AGGTCGCGCGCGATGCGGGACTGTCGCGCGAAGGTCTGTACAAGGCGCTGTCGCACGACGGCAACCCGAGCTTCGGCACG
ATCCTGAAGGTCATCAAGGCGCTCGGCCTGCAACTGCACGGCGCGAAAGCGCGCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4LKP8

Antitoxin

Source ID Structure
AlphaFold DB A0A1B4LKT2

References