58633

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-MazE
Location 842416..842978 Replicon chromosome
Accession NZ_CP013421
Organism Burkholderia ubonensis strain MSMB0783

Toxin (Protein)


Gene name mazE Uniprot ID A0A1B4LIN8
Locus tag WJ35_RS18530 Protein ID WP_011879712.1
Coordinates 842416..842736 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name mazF Uniprot ID A0A1B4LIX1
Locus tag WJ35_RS18535 Protein ID WP_045579168.1
Coordinates 842730..842978 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WJ35_RS18505 837921..838643 - 723 WP_060233992.1 ABC transporter permease subunit -
WJ35_RS18510 838731..839592 - 862 Protein_749 transporter substrate-binding domain-containing protein -
WJ35_RS18515 839902..840105 - 204 Protein_750 YhcG family protein -
WJ35_RS31390 840276..840467 - 192 WP_124259719.1 hypothetical protein -
WJ35_RS18520 840552..840737 - 186 WP_043292729.1 hypothetical protein -
WJ35_RS18525 841135..841671 - 537 WP_155121940.1 hypothetical protein -
WJ35_RS31395 841643..841888 - 246 WP_131754457.1 hypothetical protein -
WJ35_RS18530 842416..842736 - 321 WP_011879712.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
WJ35_RS18535 842730..842978 - 249 WP_045579168.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
WJ35_RS18545 843186..844375 + 1190 WP_155744937.1 IS3 family transposase -
WJ35_RS18550 844523..845632 - 1110 WP_011879708.1 NAD(P)/FAD-dependent oxidoreductase -
WJ35_RS18555 845651..846062 - 412 Protein_759 DUF2703 domain-containing protein -
WJ35_RS18560 846083..846483 - 401 Protein_760 arsenical pump-driving ATPase -
WJ35_RS30475 846575..846745 - 171 WP_080484375.1 hypothetical protein -
WJ35_RS30480 846782..847225 - 444 WP_043292565.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 840552..874410 33858


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-104)

Antitoxin

SpoVT-AbrB domain

(9-44)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 11935.23 Da        Isoelectric Point: 10.5568

>T58633 WP_011879712.1 NZ_CP013421:c842736-842416 [Burkholderia ubonensis]
MVMRGEVWLVALDPTLGSEIQKTRPCVVVSPPEMHDHLRTVIVAPMTSKGRPVPFRIPVTFKRKHGLILLDQIRAVDKVR
LVKKEGAVADKTLLDTLRTLQEVFAE

Download         Length: 321 bp

>T58633 NZ_CP013421:c842736-842416 [Burkholderia ubonensis]
ATGGTGATGCGCGGGGAAGTCTGGTTGGTCGCACTCGATCCGACGCTTGGTAGCGAGATTCAAAAGACGCGCCCCTGTGT
GGTCGTTTCACCTCCCGAAATGCACGACCACTTGCGCACTGTCATCGTCGCGCCGATGACTTCCAAGGGGCGTCCAGTGC
CGTTTCGGATTCCGGTTACGTTCAAGCGCAAACATGGTTTGATCCTTCTGGATCAGATTCGCGCAGTGGACAAGGTGCGC
TTGGTTAAGAAAGAGGGTGCAGTTGCCGATAAAACGTTGTTGGATACCCTGCGGACCTTGCAGGAAGTCTTTGCGGAATA
A

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8979.19 Da        Isoelectric Point: 4.4929

>AT58633 WP_045579168.1 NZ_CP013421:c842978-842730 [Burkholderia ubonensis]
MKTTIRRMGNSQGVLIPKPVLAQLGLESEVEMEVENDAIVLRRPKHKAREGWAEASKALAESGDDALVMGEFSNADDAEL
AW

Download         Length: 249 bp

>AT58633 NZ_CP013421:c842978-842730 [Burkholderia ubonensis]
ATGAAGACGACGATTCGCAGAATGGGTAACTCGCAGGGCGTGCTGATTCCGAAGCCCGTCCTTGCGCAACTCGGGCTGGA
GAGCGAAGTGGAAATGGAGGTCGAGAACGACGCGATTGTTCTGCGCCGCCCGAAGCACAAAGCCCGTGAGGGGTGGGCGG
AAGCAAGCAAGGCTCTGGCCGAGAGCGGCGACGATGCGCTGGTTATGGGCGAGTTTTCGAACGCCGATGACGCGGAGCTT
GCATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4LIN8

Antitoxin

Source ID Structure
AlphaFold DB A0A1B4LIX1

References