Detailed information of TA system TA058632

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): slvAT/RES(toxin)
• Location: 242387..243348
• Replicon: chromosome
• Accession: NZ_CP013421
• Organism: Burkholderia ubonensis strain MSMB0783

Toxin (Protein)

• Gene name: slvT
• Uniprot ID: A0A1B4LHJ3
• Locus tag: WJ35_RS16185
• Protein ID: WP_011880200.1
• Coordinates: 242815..243348 (+)
• Length: 178 a.a.

Antitoxin (Protein)

• Gene name: slvA
• Uniprot ID: A0A1B4LHE0
• Locus tag: WJ35_RS16180
• Protein ID: WP_011880199.1
• Coordinates: 242387..242818 (+)
• Length: 144 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WJ35_RS16155	238043..238450	-	408	WP_011880193.1	DUF934 domain-containing protein	-
WJ35_RS16160	238447..240237	-	1791	WP_069239508.1	nitrite/sulfite reductase	-
WJ35_RS30255	240371..240517	-	147	Protein_264	transposase	-
WJ35_RS16170	241314..241541	+	228	WP_043292778.1	hypothetical protein	-
WJ35_RS16175	241541..241972	+	432	WP_043292779.1	PIN domain-containing protein	-
WJ35_RS16180	242387..242818	+	432	WP_011880199.1	hypothetical protein	Antitoxin
WJ35_RS16185	242815..243348	+	534	WP_011880200.1	RES family NAD+ phosphorylase	Toxin
WJ35_RS16190	243642..245339	-	1698	WP_069239509.1	site-specific integrase	-
WJ35_RS16195	245436..245840	-	405	WP_126221107.1	hypothetical protein	-
WJ35_RS16200	245967..247400	-	1434	WP_126221193.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	238043..307678	69635

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (11-168)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 178 a.a.
• Molecular weight: 19147.77 Da
• Isoelectric Point: 5.1857

>T58632 WP_011880200.1 NZ_CP013421:242815-243348 [Burkholderia ubonensis]
MILKPLQDIIAYRMHQPKWAVAPTSGAGAAKAGGRANRVGTPALYLALEVATAVAEYQQLSPLLPPGTLVSYRVTAAPVV
DFTAGFRGDHWSPLWESFFCDWRRDWFNKRIEPPSWVLGDEVIAAGAKGILFSSTQAAGGTNLVLFVDQLDNTDRLEVID
PAGALPRDQASWGESPA

Nucleotide

• Length: 534 bp

>T58632 NZ_CP013421:242815-243348 [Burkholderia ubonensis]
ATGATCCTCAAGCCACTGCAGGACATCATCGCGTACCGGATGCACCAGCCCAAATGGGCGGTCGCGCCCACCAGTGGCGC
CGGGGCAGCGAAGGCAGGCGGGCGGGCGAACCGGGTCGGCACGCCGGCTTTGTACCTAGCCCTCGAAGTGGCTACCGCGG
TGGCCGAGTATCAGCAGCTGTCGCCGCTGCTACCGCCTGGCACGCTCGTGAGCTATCGCGTGACGGCCGCGCCCGTCGTT
GATTTCACGGCGGGCTTTCGTGGTGACCACTGGTCGCCATTGTGGGAGTCGTTCTTCTGCGACTGGCGCCGTGACTGGTT
CAACAAGCGGATCGAGCCACCAAGCTGGGTGCTAGGCGATGAGGTGATTGCCGCCGGCGCCAAAGGCATCCTGTTTTCGT
CAACGCAGGCAGCCGGCGGCACGAACCTGGTGCTGTTCGTTGACCAACTGGACAACACCGATCGCCTGGAGGTCATCGAT
CCAGCGGGCGCCTTGCCGCGCGATCAGGCCTCGTGGGGCGAGTCTCCCGCTTGA

Antitoxin

Protein

• Length: 144 a.a.
• Molecular weight: 15299.19 Da
• Isoelectric Point: 5.6277

>AT58632 WP_011880199.1 NZ_CP013421:242387-242818 [Burkholderia ubonensis]
MNTLATPSPAASAATPTGAAPVSFEAFLSSLREPDTAAPVLSARRYVAALNIDLQTLADQAHVHRNTVARAPESASVQHF
LREAIRVIRAATDLSGDVYRALFWYRNEPLAVFDYQTAETLVSAGRAEDVLRYIVSLEAGAAG

Nucleotide

• Length: 432 bp

>AT58632 NZ_CP013421:242387-242818 [Burkholderia ubonensis]
ATGAACACCCTCGCGACCCCCAGCCCAGCGGCGTCTGCGGCGACGCCCACCGGTGCGGCACCCGTCAGCTTCGAGGCCTT
TCTCAGCTCGCTACGGGAACCCGACACGGCAGCACCCGTGCTGTCGGCACGACGCTATGTGGCGGCCCTGAACATCGATC
TGCAGACGCTGGCCGACCAGGCGCATGTTCACCGAAACACCGTGGCGCGAGCCCCGGAGTCGGCATCGGTTCAGCACTTC
CTGCGCGAAGCGATCCGCGTGATTCGCGCCGCGACCGACCTGTCCGGTGACGTGTACCGCGCGTTGTTCTGGTACCGCAA
CGAGCCGCTGGCGGTGTTCGATTACCAGACAGCCGAAACGCTGGTTTCCGCCGGCCGGGCCGAGGACGTGCTGCGCTACA
TCGTGTCGCTGGAAGCGGGCGCGGCCGGATGA

Structures

Toxin

• AlphaFold DB: A0A1B4LHJ3

Antitoxin

• AlphaFold DB: A0A1B4LHE0