58630

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 2332125..2332762 Replicon chromosome
Accession NZ_CP013420
Organism Burkholderia ubonensis strain MSMB0783

Toxin (Protein)


Gene name vapC Uniprot ID A0A1B4LE75
Locus tag WJ35_RS10710 Protein ID WP_059735504.1
Coordinates 2332125..2332526 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A1B4LE78
Locus tag WJ35_RS10715 Protein ID WP_069239134.1
Coordinates 2332526..2332762 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WJ35_RS10700 2329501..2330640 + 1140 WP_060234793.1 alginate lyase family protein -
WJ35_RS10705 2330669..2332057 + 1389 WP_060234709.1 L-serine ammonia-lyase -
WJ35_RS10710 2332125..2332526 - 402 WP_059735504.1 type II toxin-antitoxin system VapC family toxin Toxin
WJ35_RS10715 2332526..2332762 - 237 WP_069239134.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
WJ35_RS10720 2333041..2334744 + 1704 WP_060234708.1 thiamine pyrophosphate-binding protein -
WJ35_RS10725 2334741..2335866 + 1126 Protein_2121 ADP-heptose--LPS heptosyltransferase -
WJ35_RS31795 2335832..2336146 - 315 WP_069239135.1 hypothetical protein -
WJ35_RS10735 2336207..2337238 - 1032 WP_069239136.1 helix-turn-helix domain-containing protein -
WJ35_RS10740 2337320..2337559 - 240 WP_060234706.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14850.01 Da        Isoelectric Point: 5.6350

>T58630 WP_059735504.1 NZ_CP013420:c2332526-2332125 [Burkholderia ubonensis]
MPRYMLDTNMCIYLMKSQPEQVAKRFAQCYTGDVVMSAITYAALEYGVTACAAPARERRHLAALIEDIPVAPFDAAAAQA
YGPVRDATRAWKKDHLDKLIAAHAVSLDVVLVTNDERDFTSYPGLRLENWLND

Download         Length: 402 bp

>T58630 NZ_CP013420:c2332526-2332125 [Burkholderia ubonensis]
ATGCCGCGCTACATGCTCGACACCAACATGTGCATCTACTTGATGAAGAGCCAGCCCGAGCAAGTGGCGAAGCGATTTGC
GCAGTGCTACACGGGCGACGTCGTGATGTCGGCGATCACGTATGCCGCGCTGGAGTACGGCGTCACCGCTTGCGCGGCGC
CCGCGCGTGAGCGCCGCCATCTTGCGGCGCTGATCGAGGATATTCCCGTCGCGCCGTTCGACGCCGCGGCCGCGCAAGCA
TATGGGCCCGTGCGTGACGCAACGCGCGCATGGAAGAAGGATCATCTCGACAAACTGATCGCCGCTCATGCGGTGTCGCT
CGATGTCGTGCTGGTGACGAATGACGAGCGCGATTTCACGAGCTATCCGGGATTGCGGCTGGAGAACTGGCTGAACGATT
AG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9008.13 Da        Isoelectric Point: 5.7316

>AT58630 WP_069239134.1 NZ_CP013420:c2332762-2332526 [Burkholderia ubonensis]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERIGDEIRIRPARRPLTQVLEKFAKFGPDFMAEGRGDHEQAEREGL

Download         Length: 237 bp

>AT58630 NZ_CP013420:c2332762-2332526 [Burkholderia ubonensis]
ATGCATACCACGAGGGTATTTCGGAACGGCAATTCGCAGGCCGTGCGAATTCCTGCGGATCTCGCTTATGAGCGCAGCGA
TATCGAGCTCGAGATCGAGCGCATCGGCGACGAGATCCGCATCCGGCCGGCGCGACGGCCGTTGACGCAGGTGCTGGAGA
AGTTCGCGAAATTCGGGCCGGATTTCATGGCGGAAGGGCGTGGCGACCACGAGCAGGCCGAACGCGAGGGGTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4LE75

Antitoxin

Source ID Structure
AlphaFold DB A0A1B4LE78

References