58629

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1724498..1725137 Replicon chromosome
Accession NZ_CP013420
Organism Burkholderia ubonensis strain MSMB0783

Toxin (Protein)


Gene name vapC Uniprot ID A0A1B4LCT6
Locus tag WJ35_RS07865 Protein ID WP_069239005.1
Coordinates 1724498..1724917 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1B4LCX0
Locus tag WJ35_RS07870 Protein ID WP_069239006.1
Coordinates 1724904..1725137 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WJ35_RS07840 1719887..1720261 - 375 WP_029226428.1 BON domain-containing protein -
WJ35_RS07845 1720700..1722124 + 1425 WP_060234351.1 ABC transporter substrate-binding protein -
WJ35_RS07850 1722237..1722875 + 639 WP_060234313.1 DsbA family protein -
WJ35_RS07855 1722974..1723926 + 953 Protein_1560 LysR family transcriptional regulator -
WJ35_RS07860 1723967..1724368 - 402 WP_069239004.1 nuclear transport factor 2 family protein -
WJ35_RS07865 1724498..1724917 - 420 WP_069239005.1 type II toxin-antitoxin system VapC family toxin Toxin
WJ35_RS07870 1724904..1725137 - 234 WP_069239006.1 DNA-binding protein Antitoxin
WJ35_RS07875 1725464..1726027 - 564 WP_069239007.1 xanthine dehydrogenase accessory protein XdhC -
WJ35_RS07880 1726029..1728380 - 2352 WP_060234316.1 xanthine dehydrogenase molybdopterin binding subunit -
WJ35_RS07885 1728397..1729941 - 1545 WP_069239008.1 xanthine dehydrogenase small subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15649.85 Da        Isoelectric Point: 6.0999

>T58629 WP_069239005.1 NZ_CP013420:c1724917-1724498 [Burkholderia ubonensis]
MFLIDTNVISEVRKRERADKGVMAFFRKAAQDDADLYLSVVTVGELRRGVEIIRHRGDKSQATRLENWLDGVLREFASNI
LGVDEEIGQLWGRLRVPHPEHSLDKLIAATALIHDLIVVTRNVDDFAGTGARVLNPFES

Download         Length: 420 bp

>T58629 NZ_CP013420:c1724917-1724498 [Burkholderia ubonensis]
ATGTTTTTGATTGATACGAACGTCATCAGCGAAGTACGGAAGCGGGAGCGAGCAGATAAAGGTGTGATGGCGTTTTTCCG
CAAGGCCGCGCAGGACGATGCCGATCTGTACCTTTCCGTGGTGACGGTTGGCGAACTGCGGCGCGGTGTGGAAATCATCC
GTCACCGTGGCGACAAGTCCCAGGCGACGCGCCTTGAAAACTGGCTCGATGGCGTACTTCGGGAGTTTGCGTCGAACATT
CTGGGGGTGGACGAAGAGATCGGGCAGTTGTGGGGACGCCTGCGCGTCCCGCATCCCGAGCACTCGCTCGACAAGTTGAT
CGCGGCAACGGCGTTGATCCACGACCTGATCGTCGTGACGCGGAACGTCGATGATTTCGCCGGAACGGGCGCACGCGTTC
TGAACCCATTCGAAAGCTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8437.47 Da        Isoelectric Point: 4.7672

>AT58629 WP_069239006.1 NZ_CP013420:c1725137-1724904 [Burkholderia ubonensis]
MATLLVRNVDEELVQSLRERAAANGRSAEAEHREILAKALRAPQRKTFAQVLMSIPNVGTDADFARVDDGEAANVFD

Download         Length: 234 bp

>AT58629 NZ_CP013420:c1725137-1724904 [Burkholderia ubonensis]
ATGGCAACTCTTCTGGTGAGAAATGTGGACGAGGAACTCGTCCAAAGCCTGCGCGAGCGGGCCGCAGCCAACGGGCGCAG
TGCGGAGGCCGAGCATCGAGAGATCCTGGCAAAGGCGCTGCGCGCGCCGCAGCGCAAGACGTTCGCGCAGGTGTTGATGA
GTATCCCGAACGTCGGAACCGATGCCGATTTTGCGCGCGTGGATGACGGCGAGGCAGCGAATGTTTTTGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4LCT6

Antitoxin

Source ID Structure
AlphaFold DB A0A1B4LCX0

References