Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 114631..115319 Replicon plasmid pMSMB0266
Accession NZ_CP013419
Organism Burkholderia sp. MSMB0266

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag WS78_RS34195 Protein ID WP_063889481.1
Coordinates 114891..115319 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag WS78_RS34190 Protein ID WP_059584004.1
Coordinates 114631..114894 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WS78_RS34155 109740..110396 - 657 WP_059583992.1 paraquat-inducible protein A -
WS78_RS34165 111040..111702 - 663 WP_059583997.1 DUF3313 domain-containing protein -
WS78_RS34170 111975..112571 + 597 WP_059583999.1 TetR/AcrR family transcriptional regulator -
WS78_RS34180 113314..114015 + 702 WP_082717564.1 hypothetical protein -
WS78_RS34185 114020..114388 + 369 WP_059584002.1 hypothetical protein -
WS78_RS34190 114631..114894 + 264 WP_059584004.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
WS78_RS34195 114891..115319 + 429 WP_063889481.1 type II toxin-antitoxin system VapC family toxin Toxin
WS78_RS34200 115331..116413 + 1083 WP_059584018.1 hypothetical protein -
WS78_RS34210 118184..119001 + 818 WP_157131171.1 IS5 family transposase -
WS78_RS34215 119083..120045 + 963 WP_059579167.1 IS5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - tssB-5 / tssC-5 / tssE-5 / tssF-5 / tssG-5 / tssI-5 / tagAB-5 / tagB-5 / tagC-5 / tagD-5 / tssJ-5 / tssK-5 / tssL-5 / bprC / bprD / bprB / bicP / bopA / bopE / bprA / bipB / bicA / bsaZ / bsaY / bsaX / spaP / bsaV / bsaT / bsaS / bsaR / bsaQ / bsaP / bsaO / bsaN / bsaM / bsaL / bsaK / basJ / orgA 1..375023 375023


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-130)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15602.02 Da        Isoelectric Point: 8.5349

>T58628 WP_063889481.1 NZ_CP013419:114891-115319 [Burkholderia sp. MSMB0266]
MKQLYMLDTNICSFIMRERPPEVLARLEACVEAQHRIMVSAITYAEMRFGSIGKKASPKHAKLVTAFVSRLDGVLPWDAA
AVDETTRIRAALAERGTPIGPNDSSIAGHAIAVGAVLVTNNTREFSRVDGLRLEDWATHALR

Download         Length: 429 bp

>T58628 NZ_CP013419:114891-115319 [Burkholderia sp. MSMB0266]
TTGAAGCAACTCTACATGCTCGATACGAACATCTGCTCGTTCATCATGCGCGAACGACCGCCCGAGGTACTCGCGCGCCT
TGAGGCCTGCGTCGAAGCGCAGCATCGCATTATGGTCTCCGCGATCACGTACGCGGAAATGCGCTTCGGGTCGATCGGTA
AAAAGGCGTCCCCGAAGCACGCCAAGCTCGTGACCGCTTTCGTGTCCCGACTCGACGGCGTGCTGCCGTGGGATGCGGCT
GCCGTCGACGAGACGACCCGGATCCGCGCGGCGCTCGCCGAGCGCGGTACACCGATCGGCCCGAACGACTCGTCGATCGC
CGGCCATGCGATCGCGGTGGGCGCCGTGCTCGTGACGAACAACACCCGCGAATTCAGCCGAGTGGACGGGCTGCGGCTCG
AGGACTGGGCGACGCACGCCTTACGATAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9851.96 Da        Isoelectric Point: 4.3331

>AT58628 WP_059584004.1 NZ_CP013419:114631-114894 [Burkholderia sp. MSMB0266]
MRTVSIFKNASNQAIRIPKDMAFEGVTELEIRREGDTLLLRPVRPTWTSFAAESRADDDFLSERPEIVEPGRFDLTGADD
EPPESSR

Download         Length: 264 bp

>AT58628 NZ_CP013419:114631-114894 [Burkholderia sp. MSMB0266]
ATGCGCACCGTTTCCATTTTCAAGAACGCCAGCAATCAGGCGATTCGCATCCCGAAGGATATGGCCTTCGAAGGGGTCAC
GGAGCTCGAGATCCGTCGGGAGGGCGACACGTTGTTGCTCCGCCCGGTCCGTCCGACGTGGACGTCGTTCGCCGCCGAGT
CGCGCGCGGACGACGACTTTCTGAGCGAGCGTCCGGAAATCGTTGAGCCCGGCCGATTCGATCTGACGGGCGCCGATGAC
GAACCGCCGGAGTCGAGCCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References