Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 243456..245233 Replicon chromosome
Accession NZ_CP013418
Organism Burkholderia sp. MSMB0266

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag WS78_RS21955 Protein ID WP_059576052.1
Coordinates 243456..244808 (-) Length 451 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag WS78_RS21960 Protein ID WP_059576049.1
Coordinates 244805..245233 (-) Length 143 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WS78_RS21935 240383..241339 - 957 WP_059576062.1 agmatinase -
WS78_RS21940 241492..242406 + 915 WP_059576058.1 LysR family transcriptional regulator -
WS78_RS21950 242668..243111 + 444 WP_059576055.1 hypothetical protein -
WS78_RS21955 243456..244808 - 1353 WP_059576052.1 type II toxin-antitoxin system HipA family toxin Toxin
WS78_RS21960 244805..245233 - 429 WP_059576049.1 helix-turn-helix domain-containing protein Antitoxin
WS78_RS21970 245933..246769 - 837 WP_038743777.1 taurine dioxygenase -
WS78_RS21975 246922..247137 - 216 Protein_234 hypothetical protein -
WS78_RS21980 247133..248143 + 1011 WP_038743780.1 taurine ABC transporter substrate-binding protein -
WS78_RS21985 248164..248946 + 783 WP_059576046.1 ATP-binding cassette domain-containing protein -
WS78_RS21990 248949..249800 + 852 WP_059576043.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(158-405)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-71)


Sequences

Toxin        


Download         Length: 451 a.a.        Molecular weight: 50028.97 Da        Isoelectric Point: 8.2000

>T58626 WP_059576052.1 NZ_CP013418:c244808-243456 [Burkholderia sp. MSMB0266]
VSARRARATRLHLWMNGLPVGYWEHARDGERLVYFDEWIADPQGRPLSLSLPFTPGNQPYRGRLVSDYFDNLLPDSEPIR
RRIAMRYRTGGTSPFELLATLGRDCVGALQMLPPDEAPDDLERIRGRALADADIARLLRDITSAPQAGQHEPLDDLRLSI
AGAQEKTALLRHRGRWLLPDGSTPTTHILKLPLGLVGNRRADMRTSVENEWLCSKIVAAYGLPVAHCDIAHFDEQKALVV
ERFDRRPSSDARWILRLPQEDMCQATGTSALDKYQADGGPGIEAIMDVLAGSEHAGDRHAFFASQIVFWLLAATDGHAKN
FSIAHLPGNRYRSTPLYDVLSAHPVIGRGANRLPAQRVRLAMGVRGKHVHYLIHQIQRWHWIAQGQRVGFAPAEVDDMID
ALTARTAGVIDEVSARLPRDFPMDVADATFSGMLRLNAKLAAETAARASR

Download         Length: 1353 bp

>T58626 NZ_CP013418:c244808-243456 [Burkholderia sp. MSMB0266]
GTGAGCGCCCGCCGCGCGCGCGCCACGCGCCTGCATCTGTGGATGAACGGCCTGCCCGTCGGCTACTGGGAGCATGCGCG
CGACGGCGAGCGCCTCGTCTACTTCGACGAATGGATCGCCGATCCGCAGGGCCGCCCGCTATCGCTGTCATTGCCGTTCA
CGCCGGGCAACCAGCCGTATCGCGGCCGGCTCGTCAGCGACTACTTCGACAACCTGCTGCCCGACAGCGAACCGATCCGG
CGCCGCATCGCGATGCGCTACAGGACGGGCGGCACGTCGCCGTTCGAGCTGCTCGCGACGCTCGGCCGCGATTGCGTCGG
CGCGCTGCAGATGCTGCCGCCCGACGAAGCGCCGGACGATCTCGAACGCATCCGCGGCCGCGCGCTCGCCGATGCGGACA
TCGCGCGGCTGCTGCGCGATATCACATCCGCGCCGCAAGCCGGGCAGCACGAGCCGCTCGACGATCTGCGCCTGTCGATC
GCGGGTGCGCAGGAAAAGACCGCGCTGCTGCGCCATCGCGGCCGCTGGCTGCTGCCCGACGGCAGCACGCCGACCACGCA
TATCCTGAAGCTGCCGCTCGGGCTCGTCGGCAACCGGCGCGCCGACATGCGCACGTCGGTCGAAAACGAATGGCTGTGCT
CGAAGATCGTCGCCGCGTACGGATTGCCGGTCGCGCATTGCGACATCGCGCACTTCGACGAGCAGAAGGCGCTCGTCGTC
GAGCGCTTCGACCGCAGGCCGTCGAGCGACGCGCGCTGGATTCTGCGCCTGCCGCAGGAAGACATGTGCCAGGCGACGGG
CACGTCCGCGCTCGACAAATATCAGGCCGACGGCGGGCCCGGCATCGAGGCGATCATGGACGTGCTCGCCGGCTCCGAGC
ACGCGGGCGACCGCCACGCGTTCTTCGCGTCGCAGATCGTGTTCTGGCTGCTCGCCGCGACCGACGGCCACGCGAAGAAT
TTCAGCATCGCGCATCTGCCCGGCAACCGCTATCGATCGACGCCGTTATACGACGTGCTGTCCGCGCATCCGGTGATCGG
CCGGGGGGCGAACCGCTTGCCGGCGCAGCGCGTGCGGCTCGCGATGGGCGTGCGCGGCAAGCACGTCCATTACCTGATCC
ATCAGATCCAGCGGTGGCACTGGATCGCGCAGGGCCAGCGCGTCGGCTTCGCGCCCGCCGAGGTCGACGACATGATCGAC
GCGTTGACCGCGCGCACCGCAGGCGTCATCGACGAAGTGTCGGCCCGGCTGCCGCGCGATTTTCCGATGGACGTCGCCGA
TGCGACCTTCAGCGGGATGCTGCGCCTGAATGCGAAGCTCGCGGCCGAAACGGCGGCGCGGGCCTCGCGATGA

Antitoxin


Download         Length: 143 a.a.        Molecular weight: 15455.01 Da        Isoelectric Point: 12.0874

>AT58626 WP_059576049.1 NZ_CP013418:c245233-244805 [Burkholderia sp. MSMB0266]
MAITIEHEIKTLDQLRPILRGFRKVAGLTQAMVASRLGVTQQTYAQFEANPASASVERLFKVLRVLNVELTLTYIHIASA
RPAAKQAIALPARKAAQASGSGRAAAKRPAPPASQSMPAPRAAERQPRPARKRAAPKKREDW

Download         Length: 429 bp

>AT58626 NZ_CP013418:c245233-244805 [Burkholderia sp. MSMB0266]
ATGGCCATCACCATCGAACACGAGATCAAGACGCTCGACCAACTACGGCCCATCCTGCGCGGCTTCCGCAAGGTGGCCGG
GTTGACGCAGGCGATGGTCGCGAGCCGCCTCGGCGTCACGCAGCAGACGTATGCGCAATTCGAGGCGAATCCGGCGTCGG
CGAGCGTCGAGCGGCTGTTCAAGGTGCTGCGCGTTCTCAACGTCGAGCTCACGCTCACCTACATCCACATCGCTTCCGCC
AGGCCCGCCGCGAAGCAAGCCATCGCCTTGCCCGCGCGCAAGGCCGCGCAGGCTTCCGGAAGCGGGCGCGCCGCCGCCAA
GCGCCCGGCGCCGCCCGCGAGCCAATCGATGCCCGCCCCGCGCGCCGCCGAGCGCCAGCCCCGCCCCGCGCGCAAGCGCG
CCGCCCCGAAGAAGCGGGAGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References