Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 1394875..1395916 | Replicon | chromosome |
| Accession | NZ_CP013417 | ||
| Organism | Burkholderia sp. MSMB0266 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | WS78_RS06995 | Protein ID | WP_059576511.1 |
| Coordinates | 1395341..1395916 (+) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | A0A132CC06 |
| Locus tag | WS78_RS06990 | Protein ID | WP_059576509.1 |
| Coordinates | 1394875..1395336 (+) | Length | 154 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| WS78_RS06965 | 1390482..1390742 | + | 261 | WP_059574446.1 | hypothetical protein | - |
| WS78_RS06970 | 1390752..1392374 | - | 1623 | WP_059670996.1 | IS66 family transposase | - |
| WS78_RS06975 | 1392474..1392827 | - | 354 | WP_059580646.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| WS78_RS06980 | 1392827..1393288 | - | 462 | WP_059584105.1 | IS66 family insertion sequence hypothetical protein | - |
| WS78_RS06985 | 1393399..1394283 | - | 885 | WP_156437539.1 | hypothetical protein | - |
| WS78_RS06990 | 1394875..1395336 | + | 462 | WP_059576509.1 | excisionase family DNA-binding protein | Antitoxin |
| WS78_RS06995 | 1395341..1395916 | + | 576 | WP_059576511.1 | PIN domain-containing protein | Toxin |
| WS78_RS07000 | 1396231..1397366 | + | 1136 | WP_156432330.1 | IS3 family transposase | - |
| WS78_RS07005 | 1397522..1397740 | - | 219 | WP_082717298.1 | DNA mismatch repair protein | - |
| WS78_RS35630 | 1398435..1398764 | - | 330 | WP_156437435.1 | hypothetical protein | - |
| WS78_RS07010 | 1399034..1399306 | + | 273 | WP_038750414.1 | hypothetical protein | - |
| WS78_RS07015 | 1399573..1400376 | - | 804 | WP_038750411.1 | inositol monophosphatase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1342010..1397366 | 55356 | |
| - | inside | IScluster/Tn | - | - | 1390752..1396539 | 5787 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 22074.41 Da Isoelectric Point: 6.4078
>T58625 WP_059576511.1 NZ_CP013417:1395341-1395916 [Burkholderia sp. MSMB0266]
MSSNFTVVYDACVLYPAPLRDLLMHLALTDLYRARWTDMIHDEWTRNLLAKRTDLKPEAIQRTRELMDMHVRDAKVENYE
HLIEVIELPDPDDRHVVAAAMHAGAELIVTMNIKDFPKERVAKYNVSAQHPDDFIVDLWDLNKHKVMEAVARHRKSMRSP
PKSVADYLDTMASQGLVQTVDALRPYAPWAI
MSSNFTVVYDACVLYPAPLRDLLMHLALTDLYRARWTDMIHDEWTRNLLAKRTDLKPEAIQRTRELMDMHVRDAKVENYE
HLIEVIELPDPDDRHVVAAAMHAGAELIVTMNIKDFPKERVAKYNVSAQHPDDFIVDLWDLNKHKVMEAVARHRKSMRSP
PKSVADYLDTMASQGLVQTVDALRPYAPWAI
Download Length: 576 bp
>T58625 NZ_CP013417:1395341-1395916 [Burkholderia sp. MSMB0266]
ATGTCGTCGAACTTTACCGTTGTCTACGATGCGTGCGTCCTATATCCGGCTCCGTTGCGCGACTTGTTGATGCATCTCGC
GCTGACGGACCTGTACCGCGCGCGTTGGACCGATATGATTCATGACGAGTGGACTAGGAATTTGCTCGCGAAGCGAACCG
ACCTGAAACCCGAGGCGATCCAGCGTACGCGGGAACTGATGGACATGCATGTTCGCGACGCGAAAGTTGAAAACTATGAG
CATCTGATCGAGGTGATCGAGTTGCCCGACCCTGACGACCGTCATGTCGTCGCGGCGGCCATGCATGCTGGGGCGGAACT
CATCGTCACGATGAACATCAAGGATTTTCCCAAGGAGCGGGTCGCAAAGTACAACGTGTCGGCGCAGCATCCCGACGACT
TTATCGTCGACTTGTGGGACTTGAACAAGCACAAGGTGATGGAGGCGGTCGCGCGACATCGCAAGTCGATGAGGAGTCCG
CCGAAGTCAGTGGCAGACTATCTCGACACGATGGCCAGCCAAGGTCTCGTACAGACGGTTGACGCGCTGCGGCCGTATGC
GCCTTGGGCTATCTGA
ATGTCGTCGAACTTTACCGTTGTCTACGATGCGTGCGTCCTATATCCGGCTCCGTTGCGCGACTTGTTGATGCATCTCGC
GCTGACGGACCTGTACCGCGCGCGTTGGACCGATATGATTCATGACGAGTGGACTAGGAATTTGCTCGCGAAGCGAACCG
ACCTGAAACCCGAGGCGATCCAGCGTACGCGGGAACTGATGGACATGCATGTTCGCGACGCGAAAGTTGAAAACTATGAG
CATCTGATCGAGGTGATCGAGTTGCCCGACCCTGACGACCGTCATGTCGTCGCGGCGGCCATGCATGCTGGGGCGGAACT
CATCGTCACGATGAACATCAAGGATTTTCCCAAGGAGCGGGTCGCAAAGTACAACGTGTCGGCGCAGCATCCCGACGACT
TTATCGTCGACTTGTGGGACTTGAACAAGCACAAGGTGATGGAGGCGGTCGCGCGACATCGCAAGTCGATGAGGAGTCCG
CCGAAGTCAGTGGCAGACTATCTCGACACGATGGCCAGCCAAGGTCTCGTACAGACGGTTGACGCGCTGCGGCCGTATGC
GCCTTGGGCTATCTGA
Antitoxin
Download Length: 154 a.a. Molecular weight: 17169.44 Da Isoelectric Point: 5.5426
>AT58625 WP_059576509.1 NZ_CP013417:1394875-1395336 [Burkholderia sp. MSMB0266]
MNTTVTPAVLPSEHEAELARESRRNLVTVVNSHAETQQFDFKDEKGDTHTVTLPTSALRLLDEILHQIGNGNAVSIIPIH
AELTTQQAADLLNVSRPYLVQLLEQGEIPFRKVNTHRRVMYLDLIQYKNKIDANRLDALAELTAQAQELGMGY
MNTTVTPAVLPSEHEAELARESRRNLVTVVNSHAETQQFDFKDEKGDTHTVTLPTSALRLLDEILHQIGNGNAVSIIPIH
AELTTQQAADLLNVSRPYLVQLLEQGEIPFRKVNTHRRVMYLDLIQYKNKIDANRLDALAELTAQAQELGMGY
Download Length: 462 bp
>AT58625 NZ_CP013417:1394875-1395336 [Burkholderia sp. MSMB0266]
ATGAACACCACTGTCACTCCTGCGGTCCTCCCGTCCGAACACGAGGCCGAGCTCGCGCGCGAGTCTCGGCGGAATTTGGT
CACGGTCGTGAACAGCCACGCCGAGACTCAGCAGTTTGATTTCAAGGACGAGAAGGGGGATACGCATACGGTCACGCTCC
CGACCTCGGCATTGAGGCTGCTAGACGAGATCCTCCATCAGATCGGAAATGGCAACGCAGTGTCGATCATTCCAATCCAT
GCCGAATTGACGACCCAGCAAGCCGCCGACCTTCTGAATGTCTCGCGTCCGTACCTAGTTCAACTTCTTGAGCAGGGCGA
GATCCCATTCCGGAAGGTAAATACGCATCGACGCGTGATGTATCTGGATCTGATTCAGTACAAAAACAAGATCGATGCGA
ACCGTCTCGACGCGCTAGCTGAACTGACGGCCCAGGCGCAAGAACTTGGAATGGGATATTGA
ATGAACACCACTGTCACTCCTGCGGTCCTCCCGTCCGAACACGAGGCCGAGCTCGCGCGCGAGTCTCGGCGGAATTTGGT
CACGGTCGTGAACAGCCACGCCGAGACTCAGCAGTTTGATTTCAAGGACGAGAAGGGGGATACGCATACGGTCACGCTCC
CGACCTCGGCATTGAGGCTGCTAGACGAGATCCTCCATCAGATCGGAAATGGCAACGCAGTGTCGATCATTCCAATCCAT
GCCGAATTGACGACCCAGCAAGCCGCCGACCTTCTGAATGTCTCGCGTCCGTACCTAGTTCAACTTCTTGAGCAGGGCGA
GATCCCATTCCGGAAGGTAAATACGCATCGACGCGTGATGTATCTGGATCTGATTCAGTACAAAAACAAGATCGATGCGA
ACCGTCTCGACGCGCTAGCTGAACTGACGGCCCAGGCGCAAGAACTTGGAATGGGATATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|