Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2848659..2849178 Replicon chromosome
Accession NZ_CP013416
Organism Burkholderia ubonensis strain MSMB2035

Toxin (Protein)


Gene name relE Uniprot ID A0A103RPZ0
Locus tag WJ32_RS31965 Protein ID WP_059750242.1
Coordinates 2848659..2848940 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A102WW84
Locus tag WJ32_RS31970 Protein ID WP_059610554.1
Coordinates 2848930..2849178 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WJ32_RS31950 2845157..2846266 + 1110 WP_059750353.1 AGE family epimerase/isomerase -
WJ32_RS31955 2846239..2847858 - 1620 WP_059750241.1 Tar ligand binding domain-containing protein -
WJ32_RS31960 2848107..2848550 + 444 WP_010090127.1 PaaI family thioesterase -
WJ32_RS31965 2848659..2848940 - 282 WP_059750242.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WJ32_RS31970 2848930..2849178 - 249 WP_059610554.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
WJ32_RS31975 2849382..2850443 - 1062 WP_059750354.1 CoA transferase -
WJ32_RS31980 2850568..2851758 - 1191 WP_059750243.1 2-methylaconitate cis-trans isomerase PrpF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2830402..2849178 18776


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-78)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10936.74 Da        Isoelectric Point: 10.5556

>T58624 WP_059750242.1 NZ_CP013416:c2848940-2848659 [Burkholderia ubonensis]
MTFELAFLEPALREWKKHDRTVRDQFKSKLAERLENPSIPSAKLHGHPDRYTIKLRSAGYRLVYEVRDKEVIVLVVAVGR
RERDAVYLAAMKR

Download         Length: 282 bp

>T58624 NZ_CP013416:c2848940-2848659 [Burkholderia ubonensis]
ATGACCTTTGAACTCGCATTTCTCGAACCTGCATTGAGAGAGTGGAAGAAGCACGATCGCACAGTTCGCGACCAGTTCAA
ATCCAAACTCGCCGAGCGGCTTGAAAATCCGAGCATACCCTCGGCAAAGCTGCACGGCCACCCGGATCGCTACACGATCA
AGCTACGCAGCGCCGGCTACCGGCTCGTCTACGAAGTGCGCGACAAGGAGGTCATCGTGCTGGTTGTCGCAGTCGGTCGG
CGCGAGCGTGATGCCGTCTATCTTGCAGCAATGAAACGTTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8975.37 Da        Isoelectric Point: 5.0636

>AT58624 WP_059610554.1 NZ_CP013416:c2849178-2848930 [Burkholderia ubonensis]
MPHTILASVTASVSELKRNPMGTVAAGEGFPVAILNHNEPAFYCIPAKTWEAMLERLEDIEDNALADARIKEKAVKVKLN
DL

Download         Length: 249 bp

>AT58624 NZ_CP013416:c2849178-2848930 [Burkholderia ubonensis]
ATGCCCCACACCATCCTGGCAAGCGTTACGGCGAGCGTCTCCGAGCTGAAGCGGAACCCGATGGGAACCGTCGCGGCGGG
AGAGGGTTTTCCGGTGGCGATCCTGAACCACAACGAACCGGCGTTCTATTGCATCCCGGCGAAGACTTGGGAGGCGATGC
TCGAACGTCTGGAGGATATCGAAGACAACGCGCTGGCTGATGCGCGTATCAAGGAGAAGGCCGTCAAGGTCAAGCTGAAT
GACCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A103RPZ0

Antitoxin

Source ID Structure
AlphaFold DB A0A102WW84

References