Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/- |
| Location | 2263607..2264843 | Replicon | chromosome |
| Accession | NZ_CP013416 | ||
| Organism | Burkholderia ubonensis strain MSMB2035 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | A0A103RVQ1 |
| Locus tag | WJ32_RS29405 | Protein ID | WP_059749333.1 |
| Coordinates | 2264262..2264843 (+) | Length | 194 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | A0A103RVG0 |
| Locus tag | WJ32_RS29400 | Protein ID | WP_059749334.1 |
| Coordinates | 2263607..2264164 (+) | Length | 186 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| WJ32_RS29375 | 2258816..2259754 | - | 939 | WP_059749338.1 | S1C family serine protease | - |
| WJ32_RS29380 | 2260053..2260952 | + | 900 | WP_059749337.1 | LysR family transcriptional regulator | - |
| WJ32_RS29385 | 2261075..2261707 | + | 633 | WP_059749336.1 | LysE family translocator | - |
| WJ32_RS29390 | 2261879..2262295 | - | 417 | WP_029226219.1 | hypothetical protein | - |
| WJ32_RS29395 | 2262630..2263361 | - | 732 | WP_059749335.1 | ribonuclease T2 | - |
| WJ32_RS29400 | 2263607..2264164 | + | 558 | WP_059749334.1 | helix-turn-helix domain-containing protein | Antitoxin |
| WJ32_RS29405 | 2264262..2264843 | + | 582 | WP_059749333.1 | HD domain-containing protein | Toxin |
| WJ32_RS29410 | 2265081..2266271 | + | 1191 | WP_059749331.1 | macrolide transporter subunit MacA | - |
| WJ32_RS29415 | 2266274..2268313 | + | 2040 | WP_059749356.1 | MacB family efflux pump subunit | - |
| WJ32_RS29420 | 2268319..2269695 | + | 1377 | WP_059749330.1 | efflux transporter outer membrane subunit | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 194 a.a. Molecular weight: 21246.91 Da Isoelectric Point: 5.5340
>T58623 WP_059749333.1 NZ_CP013416:2264262-2264843 [Burkholderia ubonensis]
MNPDTIHARLAFLREAERLKDVLRSGHTSSGRAESTAEHSWRLCLMALVFADALDGVDPLKLLKLCVVHDLGEALHGDIP
AVEQAAHPDKSAHERRDLLALTAGLDAALRDEIVALWDEYEQAVSPEAKAVKALDKLETILQHNQGDNPPDFDYAFNLGY
GRRHTDASPLFRAIRAIVDADTQSRIDAGARRA
MNPDTIHARLAFLREAERLKDVLRSGHTSSGRAESTAEHSWRLCLMALVFADALDGVDPLKLLKLCVVHDLGEALHGDIP
AVEQAAHPDKSAHERRDLLALTAGLDAALRDEIVALWDEYEQAVSPEAKAVKALDKLETILQHNQGDNPPDFDYAFNLGY
GRRHTDASPLFRAIRAIVDADTQSRIDAGARRA
Download Length: 582 bp
>T58623 NZ_CP013416:2264262-2264843 [Burkholderia ubonensis]
ATGAACCCCGACACGATCCACGCGCGGCTCGCGTTCCTGCGCGAAGCGGAACGCCTGAAGGACGTGCTGCGCAGCGGCCA
CACGTCGTCCGGCCGCGCGGAGAGCACGGCCGAGCACAGCTGGCGACTGTGCCTGATGGCGCTGGTGTTCGCCGACGCGC
TCGACGGCGTCGACCCGCTGAAGCTGCTGAAGCTGTGCGTCGTCCACGACCTCGGCGAGGCGCTGCACGGCGACATCCCG
GCGGTCGAGCAGGCCGCGCATCCGGACAAGAGCGCGCACGAGCGGCGCGACCTGCTCGCGCTGACCGCCGGCCTCGACGC
CGCGCTGCGCGACGAGATCGTCGCGCTGTGGGACGAATACGAGCAGGCCGTGTCACCGGAAGCGAAGGCCGTCAAGGCGC
TCGACAAGCTGGAAACGATCCTGCAGCACAACCAGGGCGACAATCCGCCGGACTTCGACTACGCGTTCAATCTCGGCTAC
GGGCGGCGCCATACGGACGCGAGCCCGCTGTTCCGCGCGATCCGGGCGATCGTCGACGCCGACACGCAAAGCCGGATCGA
TGCCGGCGCGCGGCGCGCGTGA
ATGAACCCCGACACGATCCACGCGCGGCTCGCGTTCCTGCGCGAAGCGGAACGCCTGAAGGACGTGCTGCGCAGCGGCCA
CACGTCGTCCGGCCGCGCGGAGAGCACGGCCGAGCACAGCTGGCGACTGTGCCTGATGGCGCTGGTGTTCGCCGACGCGC
TCGACGGCGTCGACCCGCTGAAGCTGCTGAAGCTGTGCGTCGTCCACGACCTCGGCGAGGCGCTGCACGGCGACATCCCG
GCGGTCGAGCAGGCCGCGCATCCGGACAAGAGCGCGCACGAGCGGCGCGACCTGCTCGCGCTGACCGCCGGCCTCGACGC
CGCGCTGCGCGACGAGATCGTCGCGCTGTGGGACGAATACGAGCAGGCCGTGTCACCGGAAGCGAAGGCCGTCAAGGCGC
TCGACAAGCTGGAAACGATCCTGCAGCACAACCAGGGCGACAATCCGCCGGACTTCGACTACGCGTTCAATCTCGGCTAC
GGGCGGCGCCATACGGACGCGAGCCCGCTGTTCCGCGCGATCCGGGCGATCGTCGACGCCGACACGCAAAGCCGGATCGA
TGCCGGCGCGCGGCGCGCGTGA
Antitoxin
Download Length: 186 a.a. Molecular weight: 20275.36 Da Isoelectric Point: 10.0972
>AT58623 WP_059749334.1 NZ_CP013416:2263607-2264164 [Burkholderia ubonensis]
MTDSPLQTPPLGPLLKRWRLLRRVKQSHAAELFGVAQSTISRWEAGVQQMSPDERAIAERLLAARLDSAGDRALARLVGD
HPGRMHLVCDLTHRLLACSSLRAAEFAKPLPTMLGASLWRYATPEIAALEASLDTLGWRDSAGPPSVEFDSGANASRIVP
IRRSTCRWTRMILSDGSAARLVETL
MTDSPLQTPPLGPLLKRWRLLRRVKQSHAAELFGVAQSTISRWEAGVQQMSPDERAIAERLLAARLDSAGDRALARLVGD
HPGRMHLVCDLTHRLLACSSLRAAEFAKPLPTMLGASLWRYATPEIAALEASLDTLGWRDSAGPPSVEFDSGANASRIVP
IRRSTCRWTRMILSDGSAARLVETL
Download Length: 558 bp
>AT58623 NZ_CP013416:2263607-2264164 [Burkholderia ubonensis]
ATGACCGACTCGCCGCTTCAAACGCCGCCGCTCGGCCCGTTGCTGAAACGCTGGCGGCTGCTGCGCCGCGTGAAGCAGAG
CCACGCGGCCGAGCTGTTCGGCGTCGCGCAGTCGACGATTTCCCGCTGGGAAGCCGGCGTCCAGCAGATGTCGCCCGACG
AGCGCGCGATCGCCGAGCGCCTGCTCGCGGCGCGGCTCGATTCCGCCGGCGATCGCGCGCTCGCGCGGCTCGTCGGCGAC
CATCCCGGTCGCATGCATCTCGTGTGCGACCTCACGCACCGGCTGCTGGCGTGCTCGTCGTTGCGCGCCGCCGAGTTCGC
GAAACCGCTGCCGACGATGCTCGGTGCGTCGCTGTGGCGCTATGCGACGCCGGAAATCGCCGCGCTGGAAGCGTCGCTCG
ACACGCTCGGCTGGCGCGACAGCGCCGGGCCGCCGAGCGTCGAGTTCGACAGCGGCGCGAACGCATCGCGCATCGTGCCG
ATCCGTCGCAGCACCTGCCGCTGGACGCGGATGATCCTGTCGGACGGCTCGGCCGCGCGGCTCGTCGAAACGCTGTAG
ATGACCGACTCGCCGCTTCAAACGCCGCCGCTCGGCCCGTTGCTGAAACGCTGGCGGCTGCTGCGCCGCGTGAAGCAGAG
CCACGCGGCCGAGCTGTTCGGCGTCGCGCAGTCGACGATTTCCCGCTGGGAAGCCGGCGTCCAGCAGATGTCGCCCGACG
AGCGCGCGATCGCCGAGCGCCTGCTCGCGGCGCGGCTCGATTCCGCCGGCGATCGCGCGCTCGCGCGGCTCGTCGGCGAC
CATCCCGGTCGCATGCATCTCGTGTGCGACCTCACGCACCGGCTGCTGGCGTGCTCGTCGTTGCGCGCCGCCGAGTTCGC
GAAACCGCTGCCGACGATGCTCGGTGCGTCGCTGTGGCGCTATGCGACGCCGGAAATCGCCGCGCTGGAAGCGTCGCTCG
ACACGCTCGGCTGGCGCGACAGCGCCGGGCCGCCGAGCGTCGAGTTCGACAGCGGCGCGAACGCATCGCGCATCGTGCCG
ATCCGTCGCAGCACCTGCCGCTGGACGCGGATGATCCTGTCGGACGGCTCGGCCGCGCGGCTCGTCGAAACGCTGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A103RVQ1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A103RVG0 |