58622

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2035235..2035890 Replicon chromosome
Accession NZ_CP013416
Organism Burkholderia ubonensis strain MSMB2035

Toxin (Protein)


Gene name vapC Uniprot ID A0A124REA8
Locus tag WJ32_RS28375 Protein ID WP_059748853.1
Coordinates 2035235..2035654 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A124REA9
Locus tag WJ32_RS28380 Protein ID WP_042588282.1
Coordinates 2035651..2035890 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WJ32_RS28345 2030423..2031223 + 801 WP_059748850.1 AraC family transcriptional regulator -
WJ32_RS28350 2031315..2032247 + 933 WP_059748987.1 DMT family transporter -
WJ32_RS28355 2032437..2033009 + 573 WP_059748988.1 hypothetical protein -
WJ32_RS28360 2033112..2033246 - 135 WP_029226154.1 entericidin A/B family lipoprotein -
WJ32_RS28365 2033477..2034772 + 1296 WP_059748851.1 aspartate carbamoyltransferase -
WJ32_RS28370 2034907..2035224 + 318 WP_059748852.1 hypothetical protein -
WJ32_RS28375 2035235..2035654 - 420 WP_059748853.1 type II toxin-antitoxin system VapC family toxin Toxin
WJ32_RS28380 2035651..2035890 - 240 WP_042588282.1 Arc family DNA-binding protein Antitoxin
WJ32_RS28385 2036202..2038439 + 2238 WP_059748854.1 TonB-dependent siderophore receptor -
WJ32_RS28390 2038443..2039198 + 756 WP_059748855.1 sel1 repeat family protein -
WJ32_RS28395 2039195..2039878 + 684 WP_059748856.1 Fe2+-dependent dioxygenase -
WJ32_RS28400 2040004..2040243 + 240 WP_011659184.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
WJ32_RS28405 2040240..2040635 + 396 WP_059748989.1 type II toxin-antitoxin system VapC family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(7-46)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15010.33 Da        Isoelectric Point: 5.8883

>T58622 WP_059748853.1 NZ_CP013416:c2035654-2035235 [Burkholderia ubonensis]
MILVDTNVLFEPLRPAPNASVLEWLDAQNVETLFLAAISLAEMRFGIAAMPEGKRRDWLHRSIEQRVVPAFRGRILPFDA
AASEAYAKLRARARAAGSVIAPADGYIAATAEANGLIVATRDVAPFEAAGLRVIDPWAA

Download         Length: 420 bp

>T58622 NZ_CP013416:c2035654-2035235 [Burkholderia ubonensis]
ATGATTCTTGTCGATACCAACGTCTTGTTCGAGCCGCTGCGGCCTGCGCCGAATGCGTCAGTGCTGGAGTGGCTCGATGC
GCAGAATGTCGAAACGTTGTTTCTCGCGGCGATCAGTCTGGCCGAGATGAGATTCGGTATTGCGGCCATGCCGGAAGGCA
AGCGGCGAGACTGGCTGCATCGAAGCATCGAACAACGCGTGGTGCCGGCGTTTCGCGGCCGGATCCTGCCGTTCGACGCG
GCTGCGAGCGAGGCGTATGCCAAGCTGCGCGCCCGCGCGCGGGCGGCCGGCAGCGTGATCGCGCCGGCCGACGGCTATAT
CGCCGCGACTGCCGAAGCAAATGGATTGATCGTGGCGACGCGCGACGTCGCGCCGTTTGAAGCGGCCGGCCTGCGGGTGA
TCGATCCGTGGGCGGCCTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8840.10 Da        Isoelectric Point: 5.7135

>AT58622 WP_042588282.1 NZ_CP013416:c2035890-2035651 [Burkholderia ubonensis]
MPVITVRNLPDEVHRALRVRAAQHGRSTEAEVRDILEKAVQPEGRVKLGTLLAEIGREIGGVDLDIQRDKTPTEPMNFE

Download         Length: 240 bp

>AT58622 NZ_CP013416:c2035890-2035651 [Burkholderia ubonensis]
ATGCCCGTGATAACCGTTCGGAATTTGCCTGACGAAGTCCATCGCGCCCTTCGGGTTCGCGCGGCGCAGCATGGGCGCAG
CACCGAAGCGGAGGTGCGTGACATCCTCGAGAAAGCGGTTCAGCCGGAAGGGCGCGTCAAATTGGGAACGTTGCTGGCGG
AAATCGGGCGGGAAATCGGGGGTGTCGATCTCGACATTCAGCGCGACAAAACCCCAACCGAGCCGATGAACTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A124REA8

Antitoxin

Source ID Structure
AlphaFold DB A0A124REA9

References