Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1881745..1883495 Replicon chromosome
Accession NZ_CP013416
Organism Burkholderia ubonensis strain MSMB2035

Toxin (Protein)


Gene name doc Uniprot ID A0A103RPV3
Locus tag WJ32_RS27700 Protein ID WP_059750385.1
Coordinates 1882593..1883495 (-) Length 301 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A103RPG0
Locus tag WJ32_RS27695 Protein ID WP_059750386.1
Coordinates 1881745..1882596 (-) Length 284 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WJ32_RS27675 1876955..1878445 - 1491 WP_059750390.1 aldehyde dehydrogenase -
WJ32_RS27680 1878468..1879295 - 828 WP_059750389.1 aspartate dehydrogenase -
WJ32_RS27685 1879288..1880955 - 1668 WP_059750388.1 thiamine pyrophosphate-binding protein -
WJ32_RS27690 1880948..1881745 - 798 WP_059750387.1 SDR family oxidoreductase -
WJ32_RS27695 1881745..1882596 - 852 WP_059750386.1 IclR family transcriptional regulator Antitoxin
WJ32_RS27700 1882593..1883495 - 903 WP_059750385.1 alpha/beta fold hydrolase Toxin
WJ32_RS27705 1883514..1884041 - 528 WP_059612750.1 cupin domain-containing protein -
WJ32_RS27710 1884071..1884841 - 771 WP_059750384.1 SDR family oxidoreductase -
WJ32_RS27715 1884834..1885904 - 1071 WP_059750383.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
WJ32_RS27720 1885948..1886259 - 312 WP_059612508.1 hypothetical protein -
WJ32_RS27725 1886263..1886580 - 318 WP_017329029.1 non-heme iron oxygenase ferredoxin subunit -
WJ32_RS27730 1887018..1888097 + 1080 WP_059750382.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(53-281)

Antitoxin

Transcription regulator IclR, N-terminal

(23-71)


Sequences

Toxin        


Download         Length: 301 a.a.        Molecular weight: 30895.17 Da        Isoelectric Point: 8.8230

>T58621 WP_059750385.1 NZ_CP013416:c1883495-1882593 [Burkholderia ubonensis]
MSVIDKRERGRERIASFAALLERFPEQRSPAGAAGTIGYRAAGVQHAGRTLPVVLLHGIGSGAASWVRQLDALGASRRVF
AWDAPGYGASTPVHGASPAAADYAAALGAWLDALGIDRCVLVGHSLGAIVAGGFARVMPERVAGLLLISPAGGYGSAPAE
TRASRRDARLAMLDELGPAGLAAQRSANMLSGFASEDARAWVRWNMARIVPAGYAQATHLLANADLASDLAGFRGRTAVA
VGANDAITPPAACERIAAAAHVGLQVISQAGHAGYVEAPAVYTALIETFCRQCDPQRGLA

Download         Length: 903 bp

>T58621 NZ_CP013416:c1883495-1882593 [Burkholderia ubonensis]
ATGAGTGTCATCGACAAACGTGAACGCGGCCGCGAGCGCATCGCGAGCTTCGCGGCGCTGCTCGAGCGGTTTCCCGAACA
GCGCTCGCCGGCCGGCGCGGCGGGCACGATCGGCTACCGCGCGGCCGGCGTGCAGCATGCGGGCCGCACGCTCCCCGTCG
TGCTGCTGCACGGGATCGGCTCGGGCGCCGCATCGTGGGTGCGCCAGCTCGATGCGCTCGGCGCTTCGCGGCGCGTGTTC
GCATGGGATGCGCCCGGCTACGGCGCGTCGACGCCCGTGCACGGCGCGTCGCCGGCCGCTGCCGATTACGCGGCGGCGCT
CGGCGCGTGGCTCGATGCGCTCGGCATCGACCGCTGCGTGCTGGTCGGCCATTCGCTCGGCGCGATCGTCGCGGGCGGCT
TCGCCCGCGTGATGCCGGAGCGCGTTGCCGGGCTGCTGCTGATCTCGCCCGCGGGCGGCTACGGCAGCGCGCCGGCCGAA
ACGCGCGCATCGCGCCGCGACGCGCGGCTCGCGATGCTCGACGAACTCGGCCCGGCCGGGCTCGCGGCGCAGCGCAGCGC
CAACATGCTGTCCGGCTTCGCGAGCGAGGACGCCCGTGCATGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGCCGGCT
ACGCGCAGGCGACGCACTTGCTCGCGAACGCCGATCTCGCGTCGGACCTCGCGGGTTTTCGCGGCCGCACGGCGGTGGCC
GTCGGCGCGAACGACGCGATCACGCCGCCCGCCGCATGCGAGCGGATCGCGGCGGCCGCGCACGTCGGGCTGCAGGTGAT
TTCGCAGGCCGGGCATGCGGGTTACGTCGAGGCGCCGGCTGTTTATACCGCACTGATCGAGACGTTCTGCCGTCAGTGCG
ACCCGCAGCGGGGGCTGGCATGA

Antitoxin


Download         Length: 284 a.a.        Molecular weight: 30886.33 Da        Isoelectric Point: 6.3562

>AT58621 WP_059750386.1 NZ_CP013416:c1882596-1881745 [Burkholderia ubonensis]
MSEPLLNENDGAKGDANYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYKL
GIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQAPVFSSIRVNVGTRLPAHATTHGHV
LMGDLSLGELRALYPEGALNRMTNATPGTVDALYELIREDALRGYGVSNSSFERGISVVTAPVRNDTQKIVACITVTVPR
PEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGL

Download         Length: 852 bp

>AT58621 NZ_CP013416:c1882596-1881745 [Burkholderia ubonensis]
ATGAGCGAACCGCTGCTGAATGAAAACGACGGCGCGAAGGGCGACGCGAACTACGTGGTGCCGGGCCTCGAACGGGGCTT
GAGGATCCTCGCGGAGTTCTCGCCGCGCGAGCCGGTGCTCGGCGCGCCGGAGCTGTCGAAGCGGCTCGGCATTCCGCGCA
CGACGGTGTTCCGGCTGCTGCAGACGCTCGAATCGCTCGGCTTTCTCGAGCGCGCGGACAAGGACCGCAACTACAAGCTC
GGCATCGCGGTGCTGCGGCTCGGCTTCGAATACCTGAGCTCGCTCGAGCTGACCGATCTCGGCCTGCCCGTGATCGAAAG
CCTGCGCGACGCGACCGGGTTCACGACGCACATCGTGATCCGCGACGGCCGCGACGTGGTGTTCGTCGCGAAGGCGCAGA
GCCAGGCGCCGGTGTTCAGCTCGATCCGGGTGAACGTCGGCACGCGGCTGCCGGCGCACGCGACCACGCACGGCCACGTG
CTGATGGGCGACCTGTCGCTGGGCGAGCTGCGCGCGCTGTATCCGGAGGGCGCGCTCAACCGGATGACGAACGCGACGCC
GGGCACCGTCGATGCGTTGTACGAATTGATCCGCGAGGATGCATTGCGCGGCTACGGCGTCAGCAACTCGTCGTTCGAGC
GCGGCATCTCGGTGGTCACCGCGCCGGTGCGCAACGACACGCAGAAGATCGTCGCGTGCATCACGGTGACGGTGCCGCGC
CCGGAGATCGACGCGGCGCTGATCGCGGACGGCCTGATCGACAAGGTGCAGCGCGCGGCGGCCGAGCTGTCGCGGCGGCT
CAACTACCGCTCGGACGACGAGCACACGTTTCTGAAGGCTTTGGGGTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A103RPV3

Antitoxin

Source ID Structure
AlphaFold DB A0A103RPG0

References