Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 676146..676766 Replicon chromosome
Accession NZ_CP013416
Organism Burkholderia ubonensis strain MSMB2035

Toxin (Protein)


Gene name relE Uniprot ID A0A103QTX2
Locus tag WJ32_RS22545 Protein ID WP_059759050.1
Coordinates 676449..676766 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A103QTY1
Locus tag WJ32_RS22540 Protein ID WP_059759048.1
Coordinates 676146..676445 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WJ32_RS22510 671709..672185 + 477 WP_059759040.1 aromatic-ring-hydroxylating dioxygenase subunit beta -
WJ32_RS22515 672205..672531 + 327 WP_045564530.1 non-heme iron oxygenase ferredoxin subunit -
WJ32_RS22520 672521..673741 + 1221 WP_059759042.1 FAD-dependent oxidoreductase -
WJ32_RS22525 673832..675118 + 1287 WP_059759044.1 DUF445 family protein -
WJ32_RS22530 675175..675477 - 303 WP_088501618.1 HigA family addiction module antidote protein -
WJ32_RS22535 675490..675768 - 279 WP_059759046.1 type II toxin-antitoxin system RelE/ParE family toxin -
WJ32_RS22540 676146..676445 - 300 WP_059759048.1 putative addiction module antidote protein Antitoxin
WJ32_RS22545 676449..676766 - 318 WP_059759050.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WJ32_RS22550 677180..678820 + 1641 WP_059759052.1 acetolactate synthase large subunit -
WJ32_RS22555 678850..680283 + 1434 WP_059759055.1 aldehyde dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(19-91)

Antitoxin

Uncharacterized protein HI1420

(5-93)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11922.56 Da        Isoelectric Point: 7.2759

>T58620 WP_059759050.1 NZ_CP013416:c676766-676449 [Burkholderia ubonensis]
MPYIPPVFTIRTTEFFDAWFDALQDRVAKRRIQARIDRLATGNPGDWKSVGASVVEMRIDHGPGYRVYYVQRESAWVILL
CGGDKSTQQADIRAAHAMLGHLDTE

Download         Length: 318 bp

>T58620 NZ_CP013416:c676766-676449 [Burkholderia ubonensis]
ATGCCCTACATTCCCCCTGTATTCACCATCCGAACCACCGAGTTCTTCGACGCATGGTTCGACGCGCTGCAGGATCGCGT
CGCGAAACGCCGCATCCAGGCGCGCATCGATCGGCTGGCGACGGGCAACCCGGGCGACTGGAAGTCCGTCGGCGCGTCGG
TCGTCGAAATGCGCATCGACCACGGCCCGGGCTATCGCGTCTACTACGTGCAGCGGGAATCGGCATGGGTGATCCTGCTG
TGCGGCGGCGACAAGTCGACGCAACAGGCGGACATACGCGCCGCGCACGCGATGCTCGGGCATCTCGATACGGAGTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10717.17 Da        Isoelectric Point: 6.9777

>AT58620 WP_059759048.1 NZ_CP013416:c676445-676146 [Burkholderia ubonensis]
MDKIKTRPWNSAEHLKTEDDMAEYFEACLQEAGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGSKAHA

Download         Length: 300 bp

>AT58620 NZ_CP013416:c676445-676146 [Burkholderia ubonensis]
ATGGACAAGATCAAGACCCGGCCGTGGAATTCGGCCGAACACCTGAAGACCGAAGACGACATGGCCGAGTACTTCGAAGC
CTGCCTGCAGGAGGCCGGTGACGATCCGGCCTTCATCGCGCACGCGCTCGGCGTGATCGCGCGTGCGCGCGGCATGTCGC
AGGTCGCGCGCGATGCGGGCCTGTCGCGCGAAGGTCTGTACAAGGCGCTGTCGCACGACGGCAACCCGAGCTTCGGCACG
ATCCTGAAGGTCATCAAGGCGCTCGGCCTGCAACTGCACGGCTCGAAAGCGCACGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A103QTX2

Antitoxin

Source ID Structure
AlphaFold DB A0A103QTY1

References