Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 19119..19705 Replicon plasmid pMSMB2035
Accession NZ_CP013415
Organism Burkholderia ubonensis strain MSMB2035

Toxin (Protein)


Gene name vapC Uniprot ID A0A104SY85
Locus tag WJ32_RS18300 Protein ID WP_059755189.1
Coordinates 19322..19705 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A104SY72
Locus tag WJ32_RS18295 Protein ID WP_059755186.1
Coordinates 19119..19325 (+) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WJ32_RS18275 14935..15663 + 729 WP_059755181.1 hypothetical protein -
WJ32_RS18280 15911..16768 + 858 WP_059755184.1 hypothetical protein -
WJ32_RS18285 17657..17983 + 327 WP_042585042.1 H-NS histone family protein -
WJ32_RS18290 18040..18672 - 633 WP_080410102.1 SOS response-associated peptidase family protein -
WJ32_RS18295 19119..19325 + 207 WP_059755186.1 DUF2191 domain-containing protein Antitoxin
WJ32_RS18300 19322..19705 + 384 WP_059755189.1 PIN domain-containing protein Toxin
WJ32_RS33490 19860..20003 - 144 WP_080410103.1 hypothetical protein -
WJ32_RS18305 20000..20197 - 198 WP_155122426.1 hypothetical protein -
WJ32_RS18310 20497..21744 - 1248 WP_059755196.1 replication initiation protein -
WJ32_RS18315 22814..23854 - 1041 WP_063801200.1 ParB/RepB/Spo0J family partition protein -
WJ32_RS18320 23851..24546 - 696 WP_059714374.1 ParA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..299296 299296


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-115)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14311.67 Da        Isoelectric Point: 6.7026

>T58617 WP_059755189.1 NZ_CP013415:19322-19705 [Burkholderia ubonensis]
MSVLVDTSVWVEHFRRPLPALIQLLRVDNVLTHPLVMLELTCGTPPEPRARTLGDLALLRQTRLATAAEVADWIERERLY
GRGCGTVDCTLLASVLLTPSSWLWTRDRRLAQLAEQFGVLYAPPDLH

Download         Length: 384 bp

>T58617 NZ_CP013415:19322-19705 [Burkholderia ubonensis]
TTGAGCGTCCTGGTCGACACGTCCGTGTGGGTTGAGCATTTCCGGCGGCCGCTACCGGCGCTTATCCAGCTGCTGCGCGT
CGATAACGTCTTGACGCATCCGCTGGTGATGCTCGAACTCACATGTGGGACGCCGCCCGAACCGCGGGCCCGCACCTTGG
GGGATCTCGCGCTGTTGCGTCAAACGCGACTCGCGACGGCAGCTGAGGTGGCGGACTGGATCGAGCGGGAACGGCTGTAT
GGGCGCGGATGCGGTACCGTGGATTGCACGCTGCTGGCGTCGGTGCTGTTGACCCCGAGTTCCTGGCTCTGGACGCGCGA
TCGGCGACTCGCGCAACTGGCGGAGCAATTCGGCGTCCTCTACGCACCGCCTGACCTGCATTGA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7374.49 Da        Isoelectric Point: 6.2465

>AT58617 WP_059755186.1 NZ_CP013415:19119-19325 [Burkholderia ubonensis]
MRTTVTVDDILYARALELAEPGMPPADLFRAALETFVRVQAGQRLAALGGRAPDMPDVPRRNPEAAAR

Download         Length: 207 bp

>AT58617 NZ_CP013415:19119-19325 [Burkholderia ubonensis]
ATGCGCACCACCGTTACTGTCGACGACATCCTCTACGCGCGAGCACTCGAGCTCGCCGAGCCGGGCATGCCGCCGGCCGA
TCTGTTCCGGGCCGCACTGGAAACGTTCGTGCGTGTCCAAGCCGGCCAACGCTTGGCTGCGCTCGGCGGTCGCGCGCCCG
ACATGCCGGATGTGCCGCGCCGCAACCCTGAGGCGGCCGCCCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A104SY85

Antitoxin

Source ID Structure
AlphaFold DB A0A104SY72

References