Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1962451..1963127 Replicon chromosome
Accession NZ_CP013414
Organism Burkholderia ubonensis strain MSMB2035

Toxin (Protein)


Gene name vagD Uniprot ID A0A103QVV7
Locus tag WJ32_RS08990 Protein ID WP_059758416.1
Coordinates 1962711..1963127 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A103QVW4
Locus tag WJ32_RS08985 Protein ID WP_059758413.1
Coordinates 1962451..1962714 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WJ32_RS08970 1958692..1960926 + 2235 WP_059758529.1 TonB-dependent siderophore receptor -
WJ32_RS08975 1961012..1961869 + 858 WP_059758407.1 N(5)-hydroxyornithine transformylase PvdF -
WJ32_RS08980 1961890..1962227 + 338 Protein_1803 acetyl CoA--N6-hydroxylysine acetyl transferase -
WJ32_RS08985 1962451..1962714 + 264 WP_059758413.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
WJ32_RS08990 1962711..1963127 + 417 WP_059758416.1 PIN domain-containing protein Toxin
WJ32_RS08995 1963261..1964424 + 1164 WP_059758419.1 amidohydrolase -
WJ32_RS09000 1964446..1965750 - 1305 WP_059758421.1 cobyrinate a,c-diamide synthase -
WJ32_RS09005 1965754..1966356 - 603 WP_010092402.1 cob(I)yrinic acid a,c-diamide adenosyltransferase -
WJ32_RS09010 1966385..1966762 - 378 WP_059758423.1 cobalamin biosynthesis protein -
WJ32_RS09015 1966759..1967532 - 774 WP_059758426.1 uroporphyrinogen-III C-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-130)

Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14751.85 Da        Isoelectric Point: 7.3571

>T58616 WP_059758416.1 NZ_CP013414:1962711-1963127 [Burkholderia ubonensis]
VTKLYMLDTNICSYIMRERPPVVLSRLQSYVGAQHRIVVSAVTYAEMRFGAIGKRASPKHADLVTAFVARLDGVLPWDAA
AVDATTAVRAELAARGTPIGANDASIAGHAIAAGAVLVTHNTREFGRVDGLSFEDWAD

Download         Length: 417 bp

>T58616 NZ_CP013414:1962711-1963127 [Burkholderia ubonensis]
GTGACGAAGCTCTACATGCTCGATACGAACATCTGCTCGTACATCATGCGGGAGCGCCCGCCGGTCGTGCTGTCGCGGCT
GCAGTCGTACGTCGGCGCGCAGCACCGGATCGTCGTGTCGGCGGTCACCTATGCGGAGATGCGCTTCGGTGCGATCGGCA
AGAGGGCGTCGCCGAAGCATGCCGACCTCGTGACCGCATTCGTCGCGCGGCTGGACGGCGTGCTGCCGTGGGATGCGGCA
GCCGTCGACGCGACGACCGCCGTGCGCGCCGAGCTCGCGGCGCGCGGCACGCCGATCGGCGCGAACGATGCGTCGATCGC
GGGGCACGCGATCGCGGCCGGTGCGGTGCTGGTGACCCACAACACGCGCGAATTCGGCCGCGTCGACGGGTTGTCATTCG
AGGATTGGGCGGATTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9767.97 Da        Isoelectric Point: 4.5098

>AT58616 WP_059758413.1 NZ_CP013414:1962451-1962714 [Burkholderia ubonensis]
MRTVSIFKNASNQAIRIPKDMEFEGVTELEIRREGDTLLLRPVRPTWTSLAHEPLADADFLVERPAVIESGRFDLSGPDD
AQTESGR

Download         Length: 264 bp

>AT58616 NZ_CP013414:1962451-1962714 [Burkholderia ubonensis]
ATGCGCACCGTATCCATTTTCAAGAATGCCAGCAATCAGGCGATCCGCATCCCGAAGGACATGGAGTTCGAAGGCGTGAC
GGAACTCGAGATCCGCCGCGAGGGCGACACCCTGCTGCTTCGCCCCGTGCGTCCCACGTGGACGTCGCTCGCGCACGAGC
CGCTGGCGGATGCAGATTTCCTCGTCGAGCGCCCGGCCGTCATCGAATCCGGCCGTTTCGACCTGTCCGGCCCCGACGAT
GCGCAAACGGAGTCCGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A103QVV7

Antitoxin

Source ID Structure
AlphaFold DB A0A103QVW4

References