Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1164774..1166530 Replicon chromosome
Accession NZ_CP013413
Organism Burkholderia thailandensis strain 2002721643

Toxin (Protein)


Gene name doc Uniprot ID Q2T555
Locus tag AQ477_RS23660 Protein ID WP_009900384.1
Coordinates 1164774..1165679 (+) Length 302 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q2T556
Locus tag AQ477_RS23665 Protein ID WP_009897321.1
Coordinates 1165676..1166530 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AQ477_RS23630 1160169..1161257 - 1089 WP_009900389.1 porin -
AQ477_RS23635 1161692..1162009 + 318 WP_009897336.1 non-heme iron oxygenase ferredoxin subunit -
AQ477_RS23640 1162011..1162322 + 312 WP_025405710.1 hypothetical protein -
AQ477_RS23645 1162357..1163424 + 1068 WP_045602885.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
AQ477_RS23650 1163421..1164191 + 771 WP_019255253.1 SDR family oxidoreductase -
AQ477_RS23655 1164230..1164757 + 528 WP_009897327.1 cupin domain-containing protein -
AQ477_RS23660 1164774..1165679 + 906 WP_009900384.1 alpha/beta fold hydrolase Toxin
AQ477_RS23665 1165676..1166530 + 855 WP_009897321.1 IclR family transcriptional regulator Antitoxin
AQ477_RS23670 1166527..1167324 + 798 WP_009897318.1 SDR family oxidoreductase -
AQ477_RS23675 1167317..1168990 + 1674 WP_045602883.1 thiamine pyrophosphate-binding protein -
AQ477_RS23680 1168983..1169798 + 816 WP_009897315.1 aspartate dehydrogenase -
AQ477_RS23685 1169820..1171310 + 1491 WP_019255256.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(54-285)

Antitoxin

Transcription regulator IclR, C-terminal

(143-265)


Sequences

Toxin        


Download         Length: 302 a.a.        Molecular weight: 30752.67 Da        Isoelectric Point: 8.4768

>T58614 WP_009900384.1 NZ_CP013413:1164774-1165679 [Burkholderia thailandensis]
MSAISTTTTDASATPFAALLERFAERRAAAGGARTIGYREAGAAYAAHAGRDPVVLLHGIGSGAASWVRQLDALGATRRA
LAWDAPGYGVSSRVAADSPVASDYAASLAAWLDALRIERCVLVGHSLGAIVAGAFARQAGERLSGLLLISPAGGYGGAPA
DVRAERRDSRLALLASLGPQGLAAERSANMLSAQASDAARAWVRWNMARIVPAGYAQATHLLANADLASDLAHYRGRVAV
AVGADDTITPPAACERIARAAGAGLQVIPRAGHAGYVEAPDAYNALIDAFCRQCDGSRGAA

Download         Length: 906 bp

>T58614 NZ_CP013413:1164774-1165679 [Burkholderia thailandensis]
ATGAGCGCAATCTCCACGACGACTACCGATGCGAGCGCGACGCCGTTCGCCGCGCTGCTCGAACGCTTTGCCGAGCGGCG
CGCGGCCGCGGGCGGCGCGCGTACGATCGGCTATCGCGAAGCGGGCGCAGCGTACGCCGCGCATGCCGGGCGCGATCCCG
TCGTGTTGCTGCACGGGATCGGATCGGGTGCGGCGTCGTGGGTGCGTCAACTCGATGCGCTCGGCGCGACGCGTCGCGCG
CTCGCGTGGGACGCGCCCGGCTATGGCGTCTCGTCGCGCGTCGCGGCCGATTCGCCTGTCGCATCCGACTACGCGGCGTC
GCTCGCCGCGTGGCTAGACGCGCTGCGGATCGAACGCTGCGTGCTCGTCGGCCATTCGCTCGGCGCGATCGTCGCCGGCG
CGTTCGCGCGGCAAGCGGGCGAGCGTCTTTCGGGATTGCTGCTGATTTCTCCGGCGGGCGGCTACGGCGGCGCACCCGCC
GACGTGCGGGCCGAGCGGCGCGACAGCCGCCTCGCGCTGCTCGCGTCGCTCGGCCCGCAAGGGCTCGCCGCCGAGCGCAG
CGCAAACATGCTGTCCGCGCAGGCGAGCGACGCCGCGCGCGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGCCCGCCG
GCTATGCGCAGGCGACGCACCTGCTCGCGAACGCGGACCTCGCTTCCGATCTCGCGCATTATCGCGGCCGCGTCGCGGTC
GCGGTCGGCGCCGACGATACGATCACGCCGCCCGCCGCGTGCGAGCGGATCGCGCGCGCAGCGGGCGCCGGGTTGCAGGT
GATCCCGCGCGCGGGCCATGCCGGCTATGTCGAAGCGCCGGATGCATACAACGCGTTGATCGACGCATTTTGCCGTCAAT
GCGACGGATCGCGAGGTGCGGCATGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31148.57 Da        Isoelectric Point: 6.9978

>AT58614 WP_009897321.1 NZ_CP013413:1165676-1166530 [Burkholderia thailandensis]
MSEPLLKDADDARNDSNYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYRL
GVAVLRLGFEYLSSLELTDLGLPVIEGLRDATGFTAHIVIRDGRDVVFVAKAQNAGHAFGSVRVNVGTRLPAHATTHGHV
LMGDLTLAELRTLYPERALERVTKATPETVDALFDVIRADARRGYGIGNSAFERDISVVTAPVRNEASRIVAVVTVTVPR
PEIDASLVADGLIDKVVRAAAELSRRLNYRSDDENTYLKALGLR

Download         Length: 855 bp

>AT58614 NZ_CP013413:1165676-1166530 [Burkholderia thailandensis]
ATGAGCGAGCCGCTGCTGAAGGACGCCGACGACGCGCGCAACGATTCGAACTACGTCGTGCCTGGGCTCGAGCGCGGGCT
GCGGATCCTCGCCGAGTTCTCGCCGCGCGAGCCGGTGCTCGGCGCGCCGGAGCTGTCGAAGCGGCTCGGCATTCCGCGCA
CGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTGGGCTTTCTCGAGCGCGCGGACAAGGATCGCAACTATCGCCTC
GGCGTCGCGGTGCTGCGCCTCGGCTTCGAATACCTGAGCTCGCTCGAGCTGACCGATCTCGGTTTGCCGGTGATCGAGGG
CTTGCGCGACGCGACGGGCTTCACGGCGCACATCGTGATCCGCGACGGCCGCGATGTCGTGTTCGTCGCGAAGGCGCAAA
ACGCGGGGCACGCGTTCGGCTCGGTGCGGGTGAACGTCGGCACGCGCCTGCCCGCGCACGCGACGACGCACGGCCACGTG
CTGATGGGCGACTTGACGCTCGCGGAGTTGCGCACGCTGTATCCGGAGCGGGCGCTCGAACGCGTGACGAAGGCGACGCC
CGAGACCGTCGATGCGCTGTTCGACGTGATCCGTGCCGACGCGCGCCGCGGCTACGGCATCGGCAACTCGGCGTTCGAGC
GCGACATCTCGGTCGTCACGGCGCCCGTGCGCAACGAGGCGAGCCGGATCGTCGCAGTCGTCACGGTGACGGTGCCGAGG
CCGGAGATCGATGCGTCGCTCGTCGCCGACGGGCTGATCGACAAGGTCGTGCGTGCGGCGGCCGAGCTGTCTCGGCGGCT
CAATTACCGGTCCGACGACGAAAACACCTACTTGAAGGCATTGGGATTGCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q2T555

Antitoxin

Source ID Structure
AlphaFold DB Q2T556

References