Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2186914..2187569 Replicon chromosome
Accession NZ_CP013411
Organism Burkholderia thailandensis strain 2002721643

Toxin (Protein)


Gene name relE Uniprot ID A0A0F6LEW6
Locus tag AQ477_RS09905 Protein ID WP_006027262.1
Coordinates 2187273..2187569 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q63YL3
Locus tag AQ477_RS09900 Protein ID WP_004202809.1
Coordinates 2186914..2187270 (-) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AQ477_RS34995 2182508..2183038 + 531 Protein_1955 hypothetical protein -
AQ477_RS32110 2183790..2184607 + 818 WP_102889801.1 IS5 family transposase -
AQ477_RS09885 2184616..2184915 - 300 WP_045599092.1 hypothetical protein -
AQ477_RS09890 2185447..2185842 + 396 WP_045599091.1 helix-turn-helix domain-containing protein -
AQ477_RS09895 2185893..2186870 + 978 WP_045599090.1 phage portal protein -
AQ477_RS09900 2186914..2187270 - 357 WP_004202809.1 putative addiction module antidote protein Antitoxin
AQ477_RS09905 2187273..2187569 - 297 WP_006027262.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AQ477_RS09910 2188160..2189275 - 1116 WP_045599089.1 DUF3396 domain-containing protein -
AQ477_RS09915 2189290..2190027 - 738 WP_045599088.1 VRR-NUC domain-containing protein -
AQ477_RS09920 2190024..2190557 - 534 WP_009897076.1 bacteriophage gp29 protein -
AQ477_RS09925 2190660..2190782 - 123 WP_009897078.1 CopG family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2173764..2194538 20774


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Uncharacterized protein HI1420

(16-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10844.65 Da        Isoelectric Point: 10.1723

>T58613 WP_006027262.1 NZ_CP013411:c2187569-2187273 [Burkholderia thailandensis]
MFKVLTTPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRRGKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED

Download         Length: 297 bp

>T58613 NZ_CP013411:c2187569-2187273 [Burkholderia thailandensis]
ATGTTCAAAGTTCTGACGACCCCCCAGTTTGACAAATGGCTTGACGGGCTTCGCGATCCGGTCGGTAGCGCGGCAATCAA
CCTGCGCATCGAGCGGGCGAAGCTTGGCAATCTCGGCCAGTGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTACTTCGTGCGACGCGGAAAAATTATCGTCGTGGTGTTGTGCGGCGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCTGGCGAACTGGAGGATTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12585.41 Da        Isoelectric Point: 9.9470

>AT58613 WP_004202809.1 NZ_CP013411:c2187270-2186914 [Burkholderia thailandensis]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA

Download         Length: 357 bp

>AT58613 NZ_CP013411:c2187270-2186914 [Burkholderia thailandensis]
ATGAAAATCAGCGAACTGGCCGAATTCGACGGCTCGAAGTACCTGAAGGACGAGGAAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAACCCGCGGCTGATTCAAGCCGCGCTCGGGAACGTCGCGAAAGCGCGCGGCATGACAGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTATCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTTGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAACCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F6LEW6

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4G1D3

References