Detailed information of TA system TA058609

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 2107318..2107973
• Replicon: chromosome
• Accession: NZ_CP013407
• Organism: Burkholderia thailandensis strain MSMB59

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A0F6LEW6
• Locus tag: WJ27_RS09490
• Protein ID: WP_006027262.1
• Coordinates: 2107677..2107973 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q63YL3
• Locus tag: WJ27_RS09485
• Protein ID: WP_004202809.1
• Coordinates: 2107318..2107674 (-)
• Length: 119 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WJ27_RS09465	2102453..2103466	-	1014	WP_004532901.1	phage major capsid protein, P2 family	-
WJ27_RS09470	2103500..2104309	-	810	WP_004532870.1	GPO family capsid scaffolding protein	-
WJ27_RS09475	2104453..2106222	+	1770	WP_009909354.1	terminase ATPase subunit family protein	-
WJ27_RS09480	2106219..2107274	+	1056	WP_009909353.1	phage portal protein	-
WJ27_RS09485	2107318..2107674	-	357	WP_004202809.1	putative addiction module antidote protein	Antitoxin
WJ27_RS09490	2107677..2107973	-	297	WP_006027262.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
WJ27_RS09495	2108565..2109680	-	1116	WP_038707992.1	DUF3396 domain-containing protein	-
WJ27_RS09500	2109695..2110432	-	738	WP_004532838.1	VRR-NUC domain-containing protein	-
WJ27_RS09505	2110429..2110962	-	534	WP_004532793.1	bacteriophage gp29 protein	-
WJ27_RS09510	2111065..2111187	-	123	WP_009897078.1	CopG family transcriptional regulator	-
WJ27_RS09515	2111421..2112074	-	654	WP_004532770.1	AAA family ATPase	-
WJ27_RS09520	2112164..2112370	-	207	WP_004532731.1	ogr/Delta-like zinc finger family protein	-
WJ27_RS09525	2112367..2112633	-	267	WP_009909352.1	ogr/Delta-like zinc finger family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2081533..2120848	39315

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (1-97)

Antitoxin

• Uncharacterized protein HI1420 (16-94)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 10844.65 Da
• Isoelectric Point: 10.1723

>T58609 WP_006027262.1 NZ_CP013407:c2107973-2107677 [Burkholderia thailandensis]
MFKVLTTPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRRGKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED

Nucleotide

• Length: 297 bp

>T58609 NZ_CP013407:c2107973-2107677 [Burkholderia thailandensis]
ATGTTCAAAGTTCTGACGACCCCCCAGTTTGACAAATGGCTTGACGGGCTTCGCGATCCGGTCGGTAGCGCGGCAATCAA
CCTGCGCATCGAGCGGGCGAAGCTTGGCAATCTCGGCCAGTGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTATTTCGTGCGGCGCGGAAAAATTATCGTCGTGGTGTTGTGCGGCGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCTGGCGAACTGGAGGATTGA

Antitoxin

Protein

• Length: 119 a.a.
• Molecular weight: 12585.41 Da
• Isoelectric Point: 9.9470

>AT58609 WP_004202809.1 NZ_CP013407:c2107674-2107318 [Burkholderia thailandensis]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA

Nucleotide

• Length: 357 bp

>AT58609 NZ_CP013407:c2107674-2107318 [Burkholderia thailandensis]
ATGAAAATCAGCGAACTGGCCGAGTTCGACGGCTCGAAGTACCTGAAGGACGAGGAAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAACCCGCGGCTGATTCAAGCCGCGCTCGGAAACGTCGCGAAAGCGCGCGGCATGACAGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTATCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTTGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAACCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA

Structures

Toxin

• AlphaFold DB: A0A0F6LEW6

Antitoxin

• AlphaFold DB: A0A3N4G1D3