Detailed information of TA system TA058608

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-RelB
• Location: 2461258..2461784
• Replicon: chromosome
• Accession: NZ_CP013406
• Organism: Burkholderia lata strain FL-7-5-30-S1-D0

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: WJ23_RS32795
• Protein ID: WP_069252147.1
• Coordinates: 2461515..2461784 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q399A3
• Locus tag: WJ23_RS32790
• Protein ID: WP_011354452.1
• Coordinates: 2461258..2461518 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WJ23_RS32770	2457278..2458666	+	1389	WP_069252144.1	MFS transporter	-
WJ23_RS32775	2459049..2460263	+	1215	WP_069252145.1	winged helix-turn-helix domain-containing protein	-
WJ23_RS38685	2460315..2461034	-	720	Protein_2211	GNAT family N-acetyltransferase	-
WJ23_RS32790	2461258..2461518	+	261	WP_011354452.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
WJ23_RS32795	2461515..2461784	+	270	WP_069252147.1	Txe/YoeB family addiction module toxin	Toxin
WJ23_RS32800	2461957..2462580	+	624	WP_069253007.1	HAD hydrolase-like protein	-
WJ23_RS32805	2462983..2463561	+	579	WP_069252148.1	DUF4142 domain-containing protein	-
WJ23_RS32810	2463679..2464278	-	600	WP_069252149.1	GNAT family N-acetyltransferase	-
WJ23_RS32815	2464334..2465248	-	915	WP_069252150.1	LysR family transcriptional regulator	-
WJ23_RS32820	2465358..2466596	+	1239	WP_069252151.1	diaminopimelate decarboxylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10654.99 Da
• Isoelectric Point: 7.9861

>T58608 WP_069252147.1 NZ_CP013406:2461515-2461784 [Burkholderia lata]
MSVRRVLFTSDAWDDYVYWQGQDRKTLKQRINQLIREAQRTPFEGIGKPEPLKANLSGFWSRRIDDTNRLVYEADDLQIS
IVSCRYHYE

Nucleotide

• Length: 270 bp

>T58608 NZ_CP013406:2461515-2461784 [Burkholderia lata]
ATGAGCGTACGCCGCGTGCTCTTTACTTCCGACGCGTGGGACGACTACGTCTACTGGCAGGGGCAGGATCGCAAGACGCT
CAAGCAGCGCATCAACCAGCTCATTCGCGAAGCCCAGCGAACGCCGTTCGAAGGCATTGGCAAACCCGAACCGCTAAAGG
CCAACCTCTCCGGCTTCTGGTCGCGCCGAATCGATGACACGAACCGTCTGGTCTACGAGGCCGACGACTTGCAGATCAGC
ATCGTGTCCTGCCGCTACCACTACGAATAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9700.99 Da
• Isoelectric Point: 6.4814

>AT58608 WP_011354452.1 NZ_CP013406:2461258-2461518 [Burkholderia lata]
MRTIHFSDARGNLKTVIDQVVDDADVTLITRRDAPNAVIMSQDYYDSLMETVHLLRSPANVAHLERSIAQLRKGKAKEHK
LAADEE

Nucleotide

• Length: 261 bp

>AT58608 NZ_CP013406:2461258-2461518 [Burkholderia lata]
ATGCGCACGATTCATTTTTCGGATGCCCGTGGCAATTTGAAGACCGTTATCGACCAGGTCGTCGACGATGCGGACGTGAC
GCTCATCACGCGCCGCGATGCGCCGAACGCCGTCATCATGTCGCAAGACTACTACGACAGCCTGATGGAGACCGTTCACT
TGCTGCGCTCGCCAGCCAACGTCGCCCATCTCGAACGTTCGATCGCGCAACTACGCAAGGGCAAGGCAAAGGAACACAAG
CTCGCGGCGGATGAAGAATGA

Structures

Antitoxin

• AlphaFold DB: Q399A3