Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2084496..2086243 Replicon chromosome
Accession NZ_CP013406
Organism Burkholderia lata strain FL-7-5-30-S1-D0

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag WJ23_RS31260 Protein ID WP_069251897.1
Coordinates 2085347..2086243 (-) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag WJ23_RS31255 Protein ID WP_069251896.1
Coordinates 2084496..2085350 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WJ23_RS31235 2079656..2081146 - 1491 WP_069251892.1 aldehyde dehydrogenase -
WJ23_RS31240 2081219..2082046 - 828 WP_069251893.1 aspartate dehydrogenase -
WJ23_RS31245 2082039..2083706 - 1668 WP_069251894.1 thiamine pyrophosphate-binding protein -
WJ23_RS31250 2083699..2084496 - 798 WP_069251895.1 SDR family oxidoreductase -
WJ23_RS31255 2084496..2085350 - 855 WP_069251896.1 IclR family transcriptional regulator Antitoxin
WJ23_RS31260 2085347..2086243 - 897 WP_069251897.1 alpha/beta fold hydrolase Toxin
WJ23_RS31265 2086262..2086789 - 528 WP_039344094.1 cupin domain-containing protein -
WJ23_RS31270 2086827..2087597 - 771 WP_069251898.1 SDR family oxidoreductase -
WJ23_RS31275 2087590..2088666 - 1077 WP_069251899.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
WJ23_RS31280 2088725..2089036 - 312 WP_069251900.1 hypothetical protein -
WJ23_RS31285 2089038..2089355 - 318 WP_021161517.1 non-heme iron oxygenase ferredoxin subunit -
WJ23_RS31290 2089800..2090879 + 1080 WP_069251901.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-279)

Antitoxin

Transcription regulator IclR, N-terminal

(24-72)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30573.82 Da        Isoelectric Point: 7.7126

>T58606 WP_069251897.1 NZ_CP013406:c2086243-2085347 [Burkholderia lata]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAQHAGRALPVVLLHGIGSGAASWVRQLDALGASRPVLAW
DAPGYGVSTPVQGASPAAADYAASLNAWLEALGIERCVLVGHSLGAIIAGGLARVMPARIAGLLLVSPAGGYGSAPAETR
ESRRDARLALLAELGPVGLAEQRSGNMLSGFASEDARAWVRWNMARIVPAGYAQATHLLANADLATDLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAVYSALIDTFCRQCDQQRGLA

Download         Length: 897 bp

>T58606 NZ_CP013406:c2086243-2085347 [Burkholderia lata]
ATGAGTGTCATCGACAAACGTGAACGCGACCGCACCGCGGCGTTCGCCGCGCTGCTCGGGCAGTTTCCCGAACAGCGTTG
CGCGGCCGGCGCGGCGGGCACGATCGGTTATCGCGAAGCCGGCGCGCAGCATGCGGGCCGTGCATTGCCCGTCGTGCTGT
TGCACGGCATCGGCTCGGGCGCCGCATCGTGGGTCCGCCAGCTCGACGCGCTCGGCGCATCGCGGCCCGTGCTCGCGTGG
GATGCGCCCGGTTACGGCGTGTCGACGCCGGTGCAAGGCGCGTCGCCGGCCGCCGCCGATTACGCGGCATCGCTGAACGC
GTGGCTCGAGGCACTCGGCATCGAACGCTGCGTGCTGGTTGGTCATTCGCTCGGCGCGATCATCGCGGGCGGTCTCGCCC
GCGTGATGCCCGCACGCATCGCCGGCCTGCTGCTGGTGTCGCCCGCGGGCGGCTACGGCAGCGCACCGGCTGAAACGCGT
GAATCGCGCCGCGACGCGCGGCTCGCGCTGCTCGCCGAACTCGGCCCGGTCGGGCTCGCCGAGCAGCGCAGCGGCAACAT
GCTGTCCGGTTTCGCGAGCGAGGATGCGCGGGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGCCGGCTACGCGC
AGGCCACGCATCTGCTTGCGAATGCCGATCTCGCAACGGATCTCGCCGGCTTTCGCGGCCGCACGGCCGTGGCCGTCGGC
GCGAACGACGCGATCACGCCGCCCGCTGCATGCGAGCGGATCGCTGCGGCCGCGCACGTCGGGCTGCAGGTGATTCCGCA
AGCGGGCCATGCCGGCTACGTGGAAGCACCGGCCGTCTATTCCGCACTGATCGACACGTTCTGCCGTCAGTGCGACCAAC
AGCGGGGACTGGCATGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31235.71 Da        Isoelectric Point: 6.2516

>AT58606 WP_069251896.1 NZ_CP013406:c2085350-2084496 [Burkholderia lata]
MNEPLQQPEQENGKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQAPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPEGALNRMTNATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQKIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGL

Download         Length: 855 bp

>AT58606 NZ_CP013406:c2085350-2084496 [Burkholderia lata]
ATGAACGAACCGCTGCAACAACCCGAGCAGGAAAACGGCAAGGCCGAAGCCAGCTACGTGGTCCCCGGCCTCGAACGCGG
GCTGCGGATCCTCGCCGAATTCTCGCCGCGCGAGCCCGTGCTCGGCGCGCCCGAATTGTCGAAGCGGCTCGGCATTCCGC
GCACGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGCTTCCTCGAGCGCGCGGACAAGGATCGCAACTACAAG
CTCGGCATCGCCGTGCTGCGGCTCGGCTTCGAATACCTGAGCTCGTTGGAGCTGACCGATCTCGGCCTGCCGGTGATCGA
GAGCCTGCGCGACGCGACCGGCTTCACGACGCACATCGTGATCCGTGATGGCCGCGACGTGGTGTTCGTCGCGAAGGCGC
AGAGCCAGGCGCCGGTGTTCAGCTCGATCCGCGTGAACGTCGGCACGCGCTTGCCCGCGCATGCGACGACGCACGGCCAC
GTGCTGATGGGCGACCTGTCGCTGAAGGAGCTGCATGCGCTGTATCCGGAAGGCGCGCTGAACCGGATGACGAATGCCAC
GCCGGAAACGGTCGACGCGCTGTACGAAGTGATCCGCGAGGATGCGCTGCGCGGTTACGGCGTCAGCAATTCGTCGTTCG
AGCGCGGCATCTCGGTGGTCACCGCGCCGGTGCGCAACGAGACGCAGAAGATCGTCGCGTGCATCACGGTGACGGTGCCG
AGGCCGGAAATCGACGCGGCGCTGATCGCGGACGGCCTGATCGACAAGGTGCAGCGCGCGGCGGCGGAACTGTCGCGGCG
GCTCAATTACCGCTCGGATGACGAGCACACGTTTCTCAAGGCTTTAGGACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References