Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1210424..1211070 Replicon chromosome
Accession NZ_CP013406
Organism Burkholderia lata strain FL-7-5-30-S1-D0

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag WJ23_RS27495 Protein ID WP_069251267.1
Coordinates 1210663..1211070 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag WJ23_RS27490 Protein ID WP_069251266.1
Coordinates 1210424..1210666 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WJ23_RS27475 1206439..1207845 + 1407 WP_069251263.1 aspartate ammonia-lyase -
WJ23_RS27480 1207954..1209465 + 1512 WP_069251264.1 amino acid permease -
WJ23_RS27485 1209527..1210210 - 684 WP_069251265.1 phospholipase -
WJ23_RS27490 1210424..1210666 + 243 WP_069251266.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
WJ23_RS27495 1210663..1211070 + 408 WP_069251267.1 type II toxin-antitoxin system VapC family toxin Toxin
WJ23_RS27500 1211572..1211880 + 309 WP_069251268.1 DUF485 domain-containing protein -
WJ23_RS27505 1211877..1213607 + 1731 WP_069251269.1 cation acetate symporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-121)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14816.00 Da        Isoelectric Point: 6.6451

>T58605 WP_069251267.1 NZ_CP013406:1210663-1211070 [Burkholderia lata]
MKFLLATNAVIAIMKGEPAMLARLRTYQPADFGMPAIVAHELYYGAYKSQRAAANVARVEALQFEVVSFDAEDAQHAGEI
RAHLTAAGTPIGPYDALIAGQARARRMVLVTHNVREFVRVPGLQVEDWLAEAHEN

Download         Length: 408 bp

>T58605 NZ_CP013406:1210663-1211070 [Burkholderia lata]
ATGAAATTTCTGCTGGCTACCAACGCTGTAATCGCCATCATGAAAGGCGAGCCGGCCATGCTGGCTCGACTGCGCACGTA
TCAGCCAGCAGATTTCGGCATGCCGGCGATCGTCGCGCATGAACTCTATTACGGCGCCTACAAGAGCCAGAGAGCGGCGG
CGAACGTGGCACGTGTCGAGGCACTTCAGTTCGAGGTGGTGTCGTTCGATGCGGAGGATGCTCAGCACGCCGGCGAGATT
CGTGCGCATCTGACTGCGGCGGGCACCCCGATCGGTCCGTACGATGCGTTGATCGCTGGGCAGGCACGCGCGCGGCGTAT
GGTGCTCGTCACACATAACGTGCGCGAGTTTGTGCGAGTCCCGGGGCTACAGGTCGAGGATTGGCTCGCCGAGGCGCATG
AAAACTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8963.05 Da        Isoelectric Point: 4.4536

>AT58605 WP_069251266.1 NZ_CP013406:1210424-1210666 [Burkholderia lata]
MDTAKLFKHGGSQAVRLPKDFRFDTTEVRIRRHGSSVILEPVPQDWAWLTPLIGPVDADFEAAATTEPAAEERPDLDVFE

Download         Length: 243 bp

>AT58605 NZ_CP013406:1210424-1210666 [Burkholderia lata]
ATGGATACTGCCAAGCTTTTCAAGCATGGCGGATCGCAGGCTGTCCGTCTGCCGAAGGATTTCCGCTTCGACACGACCGA
GGTCCGGATTCGTCGCCACGGTTCATCCGTCATTCTCGAGCCGGTGCCGCAAGACTGGGCATGGCTCACGCCGCTGATCG
GCCCGGTCGACGCCGATTTCGAAGCCGCCGCCACGACCGAGCCTGCCGCTGAGGAACGCCCGGATCTGGACGTATTTGAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References