Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 1922936..1923470 Replicon chromosome
Accession NZ_CP013404
Organism Burkholderia lata strain FL-7-5-30-S1-D0

Toxin (Protein)


Gene name parE Uniprot ID A0A228RAP8
Locus tag WJ23_RS08635 Protein ID WP_069247937.1
Coordinates 1923171..1923470 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A228RB25
Locus tag WJ23_RS08630 Protein ID WP_069247936.1
Coordinates 1922936..1923181 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WJ23_RS08605 1918659..1918922 + 264 WP_069249292.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
WJ23_RS08610 1918919..1919335 + 417 WP_083265877.1 PIN domain-containing protein -
WJ23_RS08615 1919384..1920275 - 892 Protein_1711 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
WJ23_RS08620 1920244..1921314 - 1071 WP_069247934.1 hypothetical protein -
WJ23_RS08625 1921656..1922819 + 1164 WP_069247935.1 amidohydrolase -
WJ23_RS08630 1922936..1923181 + 246 WP_069247936.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
WJ23_RS08635 1923171..1923470 + 300 WP_069247937.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WJ23_RS08640 1923541..1924845 - 1305 WP_069247938.1 cobyrinate a,c-diamide synthase -
WJ23_RS08645 1924848..1925450 - 603 WP_021160089.1 cob(I)yrinic acid a,c-diamide adenosyltransferase -
WJ23_RS08650 1925488..1925865 - 378 WP_069247939.1 cobalamin biosynthesis protein -
WJ23_RS08655 1925862..1926611 - 750 WP_069249294.1 uroporphyrinogen-III C-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(9-94)

Antitoxin

Antitoxin ParD

(4-72)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11725.45 Da        Isoelectric Point: 6.8704

>T58602 WP_069247937.1 NZ_CP013404:1923171-1923470 [Burkholderia lata]
MAVKSRQLQLAPLAELDLEDIWRYTVERWSLKQADLYHRDLIGTMEALARGEKAGRTCIVRDGYFRYAVGSHVVFYRETE
YTIDVIRVLHQRMDIEQHL

Download         Length: 300 bp

>T58602 NZ_CP013404:1923171-1923470 [Burkholderia lata]
ATGGCGGTTAAAAGCAGGCAGCTTCAGCTCGCACCGCTGGCCGAACTCGATCTCGAAGACATTTGGCGCTACACCGTCGA
GCGTTGGTCGCTCAAGCAAGCCGACCTTTATCACCGCGATCTGATCGGAACCATGGAAGCGCTGGCGCGCGGTGAAAAAG
CCGGTCGGACTTGCATTGTTCGCGATGGATATTTCCGGTACGCAGTGGGGTCCCACGTCGTGTTCTATCGCGAAACGGAA
TACACGATCGATGTGATTCGGGTCCTGCATCAACGCATGGACATCGAACAACATCTGTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8632.57 Da        Isoelectric Point: 6.7231

>AT58602 WP_069247936.1 NZ_CP013404:1922936-1923181 [Burkholderia lata]
MSRNTSVSLGDHFAEFVDAQVQSGRYGSASDVVRAGLRLLESHETQVRALQEALKAGEASGAPKPFDSEAFLARMRATHG
G

Download         Length: 246 bp

>AT58602 NZ_CP013404:1922936-1923181 [Burkholderia lata]
ATGTCGCGAAACACATCCGTTTCCCTGGGCGACCACTTTGCCGAATTCGTCGATGCTCAAGTGCAGTCGGGACGATACGG
TTCCGCGAGCGACGTCGTTCGAGCCGGTTTACGGCTGCTCGAGTCACACGAAACGCAGGTGCGTGCGTTGCAGGAAGCGC
TGAAGGCCGGTGAGGCATCGGGAGCGCCCAAGCCATTCGACAGCGAGGCCTTCCTGGCCCGCATGCGGGCGACGCATGGC
GGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A228RAP8

Antitoxin

Source ID Structure
AlphaFold DB A0A228RB25

References