Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2044902..2045557 Replicon chromosome
Accession NZ_CP013403
Organism Burkholderia metallica strain FL-6-5-30-S1-D7

Toxin (Protein)


Gene name vapC Uniprot ID A0A1B4I4Z6
Locus tag WJ16_RS28670 Protein ID WP_069260373.1
Coordinates 2044902..2045321 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1B4I7D3
Locus tag WJ16_RS28675 Protein ID WP_069261193.1
Coordinates 2045318..2045557 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WJ16_RS28645 2040237..2041031 + 795 WP_069260370.1 AraC family transcriptional regulator -
WJ16_RS28650 2041310..2042278 + 969 WP_069261191.1 DMT family transporter -
WJ16_RS28655 2042481..2043029 + 549 WP_069260371.1 permease -
WJ16_RS28660 2043126..2043260 - 135 WP_069261192.1 entericidin A/B family lipoprotein -
WJ16_RS28665 2043495..2044790 + 1296 WP_069260372.1 aspartate carbamoyltransferase -
WJ16_RS28670 2044902..2045321 - 420 WP_069260373.1 type II toxin-antitoxin system VapC family toxin Toxin
WJ16_RS28675 2045318..2045557 - 240 WP_069261193.1 Arc family DNA-binding protein Antitoxin
WJ16_RS28680 2045860..2048106 + 2247 WP_069261194.1 TonB-dependent siderophore receptor -
WJ16_RS28685 2048110..2048871 + 762 WP_069260374.1 sel1 repeat family protein -
WJ16_RS28690 2048868..2049551 + 684 WP_069260375.1 Fe2+-dependent dioxygenase -
WJ16_RS28695 2049898..2050137 + 240 WP_084636128.1 prevent-host-death protein -
WJ16_RS28700 2050134..2050529 + 396 WP_069261196.1 type II toxin-antitoxin system VapC family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(7-46)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15027.31 Da        Isoelectric Point: 5.8793

>T58599 WP_069260373.1 NZ_CP013403:c2045321-2044902 [Burkholderia metallica]
MILVDTNVMSEPLRREPSAAVIEWLDAQNVETLFVAAISLAEMRSGVAALPEGRRRDWLHQSIEQRVVPLFRGRILPFDD
AASKAYAGLRARARAAGSAIAPADCFIAATAEANGLMIATRDVAPFQAVGLRVIDPWAS

Download         Length: 420 bp

>T58599 NZ_CP013403:c2045321-2044902 [Burkholderia metallica]
ATGATTCTGGTCGACACGAACGTCATGTCCGAGCCGCTGCGGCGCGAGCCGAGTGCGGCCGTGATCGAGTGGCTCGATGC
GCAGAACGTCGAGACGCTATTCGTTGCCGCGATCAGTCTTGCCGAAATGCGGTCCGGCGTCGCGGCGCTGCCGGAAGGGC
GCCGGCGCGACTGGTTGCATCAAAGCATCGAGCAGCGAGTCGTGCCGTTGTTTCGCGGCCGGATCCTGCCGTTCGACGAT
GCGGCGAGCAAAGCGTATGCGGGTCTTCGCGCGCGGGCCCGGGCTGCGGGCAGTGCGATCGCGCCCGCAGACTGCTTCAT
TGCCGCGACGGCCGAGGCGAACGGATTGATGATTGCGACGCGCGACGTCGCGCCATTTCAGGCGGTCGGCTTGCGCGTGA
TCGATCCGTGGGCGTCTTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8701.97 Da        Isoelectric Point: 6.4654

>AT58599 WP_069261193.1 NZ_CP013403:c2045557-2045318 [Burkholderia metallica]
MPVITVRNLPDEVHRALRIRAAQHGRSTEAEVRDILEQAVLPVGRLKLGTLLAEIGREAGGVDFDVQRDKTPTGPMSFE

Download         Length: 240 bp

>AT58599 NZ_CP013403:c2045557-2045318 [Burkholderia metallica]
ATGCCTGTCATTACCGTTCGGAATTTGCCCGATGAAGTGCATCGGGCGCTTCGGATTCGTGCGGCCCAGCACGGGCGCAG
TACCGAAGCGGAAGTGCGTGACATTCTCGAGCAGGCGGTATTGCCGGTCGGTCGGCTGAAGCTGGGAACGCTGCTGGCGG
AAATCGGGCGGGAGGCGGGAGGTGTCGATTTCGACGTTCAACGCGACAAGACGCCAACCGGTCCGATGAGCTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4I4Z6

Antitoxin

Source ID Structure
AlphaFold DB A0A1B4I7D3

References