Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1877102..1878852 Replicon chromosome
Accession NZ_CP013403
Organism Burkholderia metallica strain FL-6-5-30-S1-D7

Toxin (Protein)


Gene name doc Uniprot ID A0A1B4I4L0
Locus tag WJ16_RS28015 Protein ID WP_069260264.1
Coordinates 1877956..1878852 (-) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1B4I4M2
Locus tag WJ16_RS28010 Protein ID WP_069260263.1
Coordinates 1877102..1877959 (-) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WJ16_RS27990 1872277..1873767 - 1491 WP_069260259.1 aldehyde dehydrogenase -
WJ16_RS27995 1873840..1874655 - 816 WP_069260260.1 aspartate dehydrogenase -
WJ16_RS28000 1874648..1876315 - 1668 WP_069260261.1 thiamine pyrophosphate-binding protein -
WJ16_RS28005 1876308..1877105 - 798 WP_069260262.1 SDR family oxidoreductase -
WJ16_RS28010 1877102..1877959 - 858 WP_069260263.1 IclR family transcriptional regulator Antitoxin
WJ16_RS28015 1877956..1878852 - 897 WP_069260264.1 alpha/beta fold hydrolase Toxin
WJ16_RS28020 1878870..1879397 - 528 WP_069260265.1 cupin domain-containing protein -
WJ16_RS28025 1879435..1880205 - 771 WP_069260266.1 SDR family oxidoreductase -
WJ16_RS28030 1880198..1881268 - 1071 WP_069260267.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
WJ16_RS28035 1881323..1881634 - 312 WP_027789383.1 hypothetical protein -
WJ16_RS28040 1881636..1881953 - 318 WP_027789384.1 non-heme iron oxygenase ferredoxin subunit -
WJ16_RS28045 1882399..1883478 + 1080 WP_069260268.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-279)

Antitoxin

Transcription regulator IclR, C-terminal

(143-266)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30603.83 Da        Isoelectric Point: 8.0625

>T58598 WP_069260264.1 NZ_CP013403:c1878852-1877956 [Burkholderia metallica]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAQHAGRALPVVLLHGIGSGAASWVRQLDTLGASRRVLAW
DAPGYGVSTPVHGESPAAADYAASLNAWLEALGIERCVLVGHSLGAIIAGGLARAMPARIAGLLLVSPAGGYGSAPAETR
ESRRDARLAMLAALGPAGLAEQRSGNMLSGFANEEARAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAVYSALIDTFCRQCDSQRGLA

Download         Length: 897 bp

>T58598 NZ_CP013403:c1878852-1877956 [Burkholderia metallica]
ATGAGTGTCATCGACAAACGTGAACGCGACCGCACCGCGGCGTTCGCCGCGCTGCTCGGGCAGTTTCCCGAACAGCGTTG
CGCGGCCGGCGCAGCGGGCACGATCGGCTACCGTGAGGCCGGCGCGCAGCATGCGGGCCGCGCGCTGCCCGTCGTGCTGC
TGCACGGCATCGGGTCGGGCGCCGCATCGTGGGTGCGCCAGCTCGACACGCTCGGCGCATCGCGGCGCGTGCTCGCGTGG
GATGCGCCCGGTTACGGCGTGTCGACGCCGGTGCACGGCGAGTCGCCGGCCGCCGCCGATTACGCGGCGTCGCTGAACGC
GTGGCTCGAGGCACTCGGCATCGAACGCTGCGTGCTGGTCGGCCACTCGCTCGGCGCGATCATCGCGGGCGGTCTCGCCC
GCGCGATGCCCGCGCGGATCGCCGGCCTGCTGCTGGTGTCGCCCGCGGGCGGCTACGGCAGCGCGCCCGCCGAAACGCGC
GAATCGCGCCGCGACGCGCGGCTCGCGATGCTCGCCGCACTCGGCCCGGCGGGGCTCGCCGAGCAGCGCAGCGGCAACAT
GCTGTCCGGTTTCGCGAACGAGGAGGCGCGCGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGCCGGCTACGCGC
AGGCCACGCATCTGCTCGCGAACGCCGATCTCGCGGCCGATCTCGCCGGTTTTCGCGGCCGCACGGCCGTGGCCGTCGGC
GCGAACGACGCGATCACGCCGCCTGCCGCGTGCGAGCGGATCGCCGCGGCCGCGCACGTCGGGCTGCAGGTGATTCCGCA
AGCCGGTCATGCCGGCTATGTCGAGGCACCGGCCGTTTATTCCGCACTGATCGACACGTTCTGCCGTCAGTGCGACTCGC
AGCGGGGGCTGGCATGA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31400.03 Da        Isoelectric Point: 6.9861

>AT58598 WP_069260263.1 NZ_CP013403:c1877959-1877102 [Burkholderia metallica]
MNEPLKQPELENAKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQAPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELQALYPEGTLNRMTNATPETVDALYAVIREDALRGYGVSNSSFERGISVVTAPVRNETQRIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFMKALGLR

Download         Length: 858 bp

>AT58598 NZ_CP013403:c1877959-1877102 [Burkholderia metallica]
ATGAACGAACCGCTGAAACAACCCGAACTCGAGAACGCGAAGGCCGAAGCCAGTTACGTCGTGCCCGGCCTCGAACGCGG
GCTGCGGATCCTCGCGGAATTCTCGCCGCGCGAGCCCGTGCTCGGTGCGCCCGAGCTGTCGAAGCGGCTCGGCATTCCGC
GCACGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGCTTCCTCGAGCGCGCGGACAAGGATCGCAACTACAAG
CTCGGCATCGCCGTGCTGCGGCTCGGTTTCGAATACCTGAGCTCGCTGGAGCTGACCGATCTCGGCCTGCCGGTGATCGA
GAGCCTGCGCGATGCGACCGGCTTCACGACGCACATCGTGATCCGCGACGGCCGCGACGTGGTGTTCGTCGCGAAGGCGC
AGAGCCAGGCGCCGGTGTTCAGCTCGATCCGCGTGAACGTCGGCACGCGCCTGCCCGCGCATGCGACGACGCACGGCCAC
GTGCTGATGGGCGACCTGTCGTTGAAGGAACTGCAAGCGCTGTATCCGGAAGGCACGCTGAACCGGATGACGAACGCGAC
GCCGGAAACGGTCGACGCGCTGTATGCGGTGATCCGCGAGGATGCGCTGCGCGGCTACGGCGTCAGCAACTCGTCGTTCG
AGCGCGGCATTTCGGTGGTCACGGCGCCGGTGCGCAACGAAACGCAGCGGATCGTCGCGTGCATCACGGTGACGGTGCCG
CGGCCGGAAATCGACGCGGCGCTGATCGCGGACGGCCTGATCGACAAGGTGCAGCGCGCGGCGGCGGAACTGTCGCGGCG
GCTCAATTACCGCTCGGACGACGAGCACACGTTCATGAAAGCATTAGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4I4L0

Antitoxin

Source ID Structure
AlphaFold DB A0A1B4I4M2

References