Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 739031..739672 Replicon chromosome
Accession NZ_CP013403
Organism Burkholderia metallica strain FL-6-5-30-S1-D7

Toxin (Protein)


Gene name relE Uniprot ID A0A1B4I222
Locus tag WJ16_RS23080 Protein ID WP_069259387.1
Coordinates 739334..739672 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U2GAF3
Locus tag WJ16_RS23075 Protein ID WP_021157290.1
Coordinates 739031..739330 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WJ16_RS23050 734234..735505 + 1272 WP_069259384.1 Rieske 2Fe-2S domain-containing protein -
WJ16_RS23055 735521..735997 + 477 WP_006490977.1 aromatic-ring-hydroxylating dioxygenase subunit beta -
WJ16_RS23060 736019..736345 + 327 WP_006479527.1 non-heme iron oxygenase ferredoxin subunit -
WJ16_RS23065 736335..737555 + 1221 WP_069259385.1 FAD-dependent oxidoreductase -
WJ16_RS23070 737696..738982 + 1287 WP_069259386.1 DUF445 domain-containing protein -
WJ16_RS23075 739031..739330 - 300 WP_021157290.1 putative addiction module antidote protein Antitoxin
WJ16_RS23080 739334..739672 - 339 WP_069259387.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WJ16_RS23085 740002..741642 + 1641 WP_069259388.1 acetolactate synthase large subunit -
WJ16_RS23090 741670..743103 + 1434 WP_069259389.1 aldehyde dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(26-98)

Antitoxin

Uncharacterized protein HI1420

(6-93)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12563.42 Da        Isoelectric Point: 8.9480

>T58596 WP_069259387.1 NZ_CP013403:c739672-739334 [Burkholderia metallica]
MVDTLPSLPYSAPTFSVRTTDVFDTWFAGLPDRVAKRRIQARIDRLSMGNPGDWKSAGSPVVEMRIDHGPGYRVYYVRRA
TIWVILLCGGDKSTQQADIRAAHAMLAHLDME

Download         Length: 339 bp

>T58596 NZ_CP013403:c739672-739334 [Burkholderia metallica]
ATGGTTGACACATTGCCATCCTTGCCCTACAGTGCCCCTACGTTCAGCGTCCGGACCACCGACGTCTTCGACACCTGGTT
TGCCGGCCTGCCGGATCGCGTCGCGAAGCGCCGCATCCAGGCACGCATCGACCGCCTGTCGATGGGCAATCCGGGCGACT
GGAAGTCCGCCGGATCGCCGGTCGTCGAGATGCGGATCGACCACGGCCCCGGCTATCGCGTCTACTACGTCCGGCGCGCA
ACGATCTGGGTCATCCTGCTCTGCGGCGGCGATAAATCGACGCAACAGGCCGACATCCGCGCCGCGCACGCAATGCTCGC
GCATCTCGACATGGAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10633.01 Da        Isoelectric Point: 6.3217

>AT58596 WP_021157290.1 NZ_CP013403:c739330-739031 [Burkholderia metallica]
MDKISTRPWDSADHLKTEDDMADYFEACLQEAGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAHA

Download         Length: 300 bp

>AT58596 NZ_CP013403:c739330-739031 [Burkholderia metallica]
ATGGACAAGATCAGCACCCGGCCGTGGGATTCGGCCGACCATCTGAAAACCGAAGACGACATGGCCGACTACTTCGAAGC
GTGCCTGCAGGAAGCCGGCGACGATCCAGCCTTCATCGCGCACGCGCTCGGCGTGATCGCGCGCGCACGCGGCATGTCGC
AGGTCGCGCGCGATGCGGGCCTGTCTCGCGAAGGGCTGTACAAGGCGCTGTCGCACGACGGCAACCCGAGCTTCGGCACG
ATCCTGAAGGTCATCAAGGCGCTCGGCCTGCAACTGCACGGCGCGAAAGCGCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4I222

Antitoxin

Source ID Structure
AlphaFold DB U2GAF3

References