58594

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/Tad-HTH_37
Location 2705130..2705830 Replicon chromosome
Accession NZ_CP013401
Organism Burkholderia metallica strain FL-6-5-30-S1-D7

Toxin (Protein)


Gene name tad Uniprot ID A0A1B4HVV2
Locus tag WJ16_RS12160 Protein ID WP_069257265.1
Coordinates 2705130..2705510 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID A0A1B4HVJ6
Locus tag WJ16_RS12165 Protein ID WP_069257266.1
Coordinates 2705507..2705830 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WJ16_RS12140 2701199..2701654 + 456 WP_069257261.1 VOC family protein -
WJ16_RS12145 2701715..2703265 - 1551 WP_069257262.1 sodium:solute symporter family protein -
WJ16_RS12150 2703262..2703504 - 243 WP_069257263.1 DUF3311 domain-containing protein -
WJ16_RS12155 2703703..2704620 - 918 WP_069257264.1 spermidine synthase -
WJ16_RS12160 2705130..2705510 + 381 WP_069257265.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WJ16_RS12165 2705507..2705830 + 324 WP_069257266.1 helix-turn-helix domain-containing protein Antitoxin
WJ16_RS12170 2705895..2706371 - 477 WP_069257267.1 DNA-deoxyinosine glycosylase -
WJ16_RS12175 2706371..2706967 - 597 WP_069258042.1 chorismate lyase -
WJ16_RS12180 2706976..2708874 - 1899 WP_069257268.1 molecular chaperone HtpG -
WJ16_RS12185 2709029..2710489 - 1461 WP_069257269.1 PLP-dependent aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(22-115)

Antitoxin

HigA2-like, helix-turn-helix domain

(11-89)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13887.84 Da        Isoelectric Point: 9.9131

>T58594 WP_069257265.1 NZ_CP013401:2705130-2705510 [Burkholderia metallica]
MGINSSMDPYTKPLYWLGSARKDLKAMPEAVQDTFGYTLYLAQTGRKHDQAKPLSGFGSAGVLEIVESEDHGTYRAVYTV
KLGNSVYVLHCFQKKSASGIATPKPDRDLVRERLKAAEAHAKGARR

Download         Length: 381 bp

>T58594 NZ_CP013401:2705130-2705510 [Burkholderia metallica]
ATGGGAATAAATTCGTCGATGGATCCGTACACCAAACCGCTCTACTGGCTGGGCTCGGCGCGCAAAGACCTGAAAGCGAT
GCCCGAAGCCGTGCAGGACACGTTCGGCTATACGCTGTATCTGGCCCAGACGGGGCGAAAGCACGACCAGGCCAAGCCGT
TGAGCGGATTCGGATCGGCAGGCGTGCTCGAGATCGTGGAATCGGAAGACCACGGTACGTACCGCGCCGTCTACACGGTA
AAGCTCGGCAACAGCGTGTACGTGCTGCACTGTTTTCAGAAGAAATCGGCGAGCGGCATCGCGACACCGAAACCGGACCG
CGATCTGGTGCGCGAACGGCTGAAAGCCGCCGAAGCACACGCAAAAGGAGCAAGGCGATGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11872.81 Da        Isoelectric Point: 9.8808

>AT58594 WP_069257266.1 NZ_CP013401:2705507-2705830 [Burkholderia metallica]
MTEIEPGSGNVYADLGMRDADEMRVKAQLAAKIAEIIKSRRWTQQHAARLLGMTQPKLSNMLRGQFRGVSETKMLECLAK
LGRDVRIVVGPDRHSEIAGHIEVVFAA

Download         Length: 324 bp

>AT58594 NZ_CP013401:2705507-2705830 [Burkholderia metallica]
ATGACCGAAATCGAACCGGGCAGCGGAAACGTCTACGCTGATCTGGGCATGCGCGATGCGGACGAAATGCGGGTGAAAGC
CCAGCTCGCCGCCAAGATCGCGGAGATCATCAAGTCACGACGGTGGACGCAGCAGCATGCGGCCCGGTTGCTCGGCATGA
CGCAGCCGAAGCTGTCGAACATGCTGCGCGGGCAGTTTCGCGGCGTGAGCGAAACGAAGATGCTCGAATGTCTGGCGAAG
CTCGGGCGCGATGTGCGGATCGTCGTCGGGCCGGACCGTCATTCGGAAATCGCGGGGCACATCGAAGTCGTATTCGCCGC
GTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4HVV2

Antitoxin

Source ID Structure
AlphaFold DB A0A1B4HVJ6

References