Detailed information of TA system TA058593

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbE-relB/ParE(toxin)
• Location: 2896141..2896651
• Replicon: chromosome
• Accession: NZ_CP013400
• Organism: Burkholderia seminalis strain FL-5-4-10-S1-D7

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: -
• Locus tag: WJ12_RS35645
• Protein ID: WP_082744724.1
• Coordinates: 2896141..2896422 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: WJ12_RS33420
• Protein ID: WP_059559126.1
• Coordinates: 2896412..2896651 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WJ12_RS33400	2891790..2892488	-	699	WP_034187673.1	MgtC/SapB family protein	-
WJ12_RS33405	2892604..2893713	+	1110	WP_059559119.1	AGE family epimerase/isomerase	-
WJ12_RS33410	2893686..2895305	-	1620	WP_059559122.1	Tar ligand binding domain-containing protein	-
WJ12_RS33415	2895577..2896020	+	444	WP_034187670.1	PaaI family thioesterase	-
WJ12_RS35645	2896141..2896422	-	282	WP_082744724.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
WJ12_RS33420	2896412..2896651	-	240	WP_059559126.1	plasmid stabilization protein	Antitoxin
WJ12_RS33425	2896789..2897847	-	1059	WP_059559300.1	CoA transferase	-
WJ12_RS33430	2898007..2899197	-	1191	WP_034187668.1	2-methylaconitate cis-trans isomerase PrpF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (12-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10842.50 Da
• Isoelectric Point: 10.2661

>T58593 WP_082744724.1 NZ_CP013400:c2896422-2896141 [Burkholderia seminalis]
MTFERAFLEPELREWKKLDRTGRDRFKAGLAERIEHPRVPSAELHGHPDRDRIKLRGVGYRLVYEVRDSEVVVLVVAVGR
REGDAVYLAAMKR

Nucleotide

• Length: 282 bp

>T58593 NZ_CP013400:c2896422-2896141 [Burkholderia seminalis]
ATGACCTTTGAACGTGCCTTTCTCGAACCTGAATTGAGGGAGTGGAAGAAACTCGATCGCACTGGTCGCGATCGATTCAA
GGCCGGGCTTGCCGAGCGGATCGAGCATCCTCGCGTTCCCTCGGCCGAACTGCATGGCCACCCGGATCGTGACAGGATCA
AGCTGCGCGGCGTCGGCTACCGACTCGTCTACGAAGTACGCGATTCGGAAGTTGTCGTTCTGGTCGTCGCAGTCGGCCGG
CGTGAAGGCGATGCAGTCTATCTTGCCGCGATGAAACGTTAG

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8549.80 Da
• Isoelectric Point: 6.4509

>AT58593 WP_059559126.1 NZ_CP013400:c2896651-2896412 [Burkholderia seminalis]
MPHTMLASVTASVSALKRNPMGTVAAGEGFPVAILNHNEPAFYCIPAKTWGERLQDIEDNALADSRAKERVVKVTLNDL

Nucleotide

• Length: 240 bp

>AT58593 NZ_CP013400:c2896651-2896412 [Burkholderia seminalis]
ATGCCTCACACCATGCTGGCCAGCGTGACCGCGAGCGTTTCGGCGCTGAAACGGAACCCGATGGGGACGGTCGCGGCAGG
AGAGGGCTTCCCGGTCGCGATTCTGAATCACAACGAGCCTGCGTTCTATTGCATTCCGGCGAAGACGTGGGGCGAACGTC
TGCAAGACATTGAAGACAATGCGTTGGCCGATTCGCGCGCCAAGGAGAGGGTCGTCAAGGTCACGCTGAATGACCTTTGA