Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2126442..2127097 Replicon chromosome
Accession NZ_CP013400
Organism Burkholderia seminalis strain FL-5-4-10-S1-D7

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag WJ12_RS30130 Protein ID WP_059556772.1
Coordinates 2126442..2126861 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag WJ12_RS30135 Protein ID WP_034189436.1
Coordinates 2126858..2127097 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WJ12_RS30105 2121886..2122680 + 795 WP_034189440.1 AraC family transcriptional regulator -
WJ12_RS30110 2122861..2123814 + 954 WP_059556954.1 DMT family transporter -
WJ12_RS30115 2124001..2124549 + 549 WP_034189439.1 hypothetical protein -
WJ12_RS30120 2124647..2124781 - 135 WP_021158165.1 entericidin A/B family lipoprotein -
WJ12_RS30125 2125015..2126310 + 1296 WP_034189438.1 aspartate carbamoyltransferase -
WJ12_RS30130 2126442..2126861 - 420 WP_059556772.1 type II toxin-antitoxin system VapC family toxin Toxin
WJ12_RS30135 2126858..2127097 - 240 WP_034189436.1 Arc family DNA-binding protein Antitoxin
WJ12_RS30140 2127419..2129662 + 2244 WP_059556773.1 TonB-dependent siderophore receptor -
WJ12_RS30145 2129666..2130421 + 756 WP_034189434.1 sel1 repeat family protein -
WJ12_RS30150 2130418..2131101 + 684 WP_034189433.1 Fe2+-dependent dioxygenase -
WJ12_RS30155 2131222..2131461 + 240 WP_082744637.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
WJ12_RS30160 2131458..2131853 + 396 WP_059556955.1 type II toxin-antitoxin system VapC family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(6-46)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15029.32 Da        Isoelectric Point: 7.1679

>T58591 WP_059556772.1 NZ_CP013400:c2126861-2126442 [Burkholderia seminalis]
MILVDTNVISEPLRREPSAAVVEWLDAQHVETLFLSAVSLAELRFGVAALPEGRRRDWLHQGIEQRVVPLFRGRILPFDD
AASKAYASLCARARAAGNAVAVADGYIAATAEANGLIVAARDVAPFKALGLRVIDPWAR

Download         Length: 420 bp

>T58591 NZ_CP013400:c2126861-2126442 [Burkholderia seminalis]
ATGATCCTGGTCGACACGAACGTCATTTCGGAGCCGTTGCGGCGCGAGCCGAGCGCGGCAGTCGTCGAGTGGCTCGATGC
GCAGCACGTCGAGACGCTGTTCCTGTCGGCGGTCAGTCTTGCGGAATTGCGGTTCGGCGTCGCCGCGTTGCCGGAGGGGC
GCAGGCGGGACTGGCTGCATCAAGGCATCGAGCAGCGCGTCGTCCCGCTGTTTCGAGGTCGGATCCTGCCGTTCGACGAT
GCGGCGAGCAAAGCGTATGCGAGCCTTTGCGCGCGGGCTCGTGCCGCAGGCAACGCGGTCGCCGTCGCCGATGGTTACAT
TGCCGCCACGGCCGAGGCGAACGGGCTGATCGTGGCCGCGCGCGACGTCGCGCCGTTCAAGGCGCTCGGGCTTCGCGTCA
TCGACCCTTGGGCGCGATAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8718.92 Da        Isoelectric Point: 5.1133

>AT58591 WP_034189436.1 NZ_CP013400:c2127097-2126858 [Burkholderia seminalis]
MPVLTVRNLPDEVHRALRIRAARHGRSTEAEVRDILEQAVLPEGRLKLGTLLAEFGPEAGDDDFGIQRDKAPAAPMSFE

Download         Length: 240 bp

>AT58591 NZ_CP013400:c2127097-2126858 [Burkholderia seminalis]
ATGCCAGTGCTCACCGTTCGAAATTTGCCCGACGAAGTGCATCGCGCACTTCGGATTCGTGCTGCCCGGCATGGTCGCAG
TACCGAAGCCGAGGTGCGCGACATCCTCGAACAAGCCGTTCTGCCCGAGGGGCGGCTCAAGCTGGGAACATTGCTGGCGG
AATTCGGGCCGGAGGCAGGCGATGACGATTTCGGCATCCAGCGCGACAAGGCGCCAGCCGCTCCGATGAGCTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References