Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-MazE
Location 749106..749668 Replicon chromosome
Accession NZ_CP013395
Organism Burkholderia vietnamiensis strain FL-2-3-30-S1-D0

Toxin (Protein)


Gene name mazE Uniprot ID A0A1B4LIN8
Locus tag WJ02_RS28030 Protein ID WP_011879712.1
Coordinates 749106..749426 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name mazF Uniprot ID A0A1B4LIX1
Locus tag WJ02_RS28035 Protein ID WP_045579168.1
Coordinates 749420..749668 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WJ02_RS28005 744609..745331 - 723 WP_011879718.1 ABC transporter permease subunit -
WJ02_RS28010 745424..746284 - 861 WP_045579531.1 transporter substrate-binding domain-containing protein -
WJ02_RS28015 746594..746797 - 204 Protein_658 YhcG family protein -
WJ02_RS31885 746968..747159 - 192 WP_124259719.1 hypothetical protein -
WJ02_RS28020 747244..747429 - 186 WP_043292729.1 hypothetical protein -
WJ02_RS28025 747471..748361 - 891 WP_155769879.1 hypothetical protein -
WJ02_RS31890 748333..748578 - 246 WP_131754457.1 hypothetical protein -
WJ02_RS28030 749106..749426 - 321 WP_011879712.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
WJ02_RS28035 749420..749668 - 249 WP_045579168.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
WJ02_RS28045 749876..751065 + 1190 WP_155744937.1 IS3 family transposase -
WJ02_RS28050 751213..752322 - 1110 WP_011879708.1 NAD(P)/FAD-dependent oxidoreductase -
WJ02_RS28055 752341..752752 - 412 Protein_667 DUF2703 domain-containing protein -
WJ02_RS28060 752773..753173 - 401 Protein_668 arsenical pump-driving ATPase -
WJ02_RS32150 753265..753435 - 171 WP_080484375.1 hypothetical protein -
WJ02_RS31090 753472..753915 - 444 WP_155769880.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 747471..777048 29577


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-104)

Antitoxin

SpoVT-AbrB domain

(9-44)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 11935.23 Da        Isoelectric Point: 10.5568

>T58586 WP_011879712.1 NZ_CP013395:c749426-749106 [Burkholderia vietnamiensis]
MVMRGEVWLVALDPTLGSEIQKTRPCVVVSPPEMHDHLRTVIVAPMTSKGRPVPFRIPVTFKRKHGLILLDQIRAVDKVR
LVKKEGAVADKTLLDTLRTLQEVFAE

Download         Length: 321 bp

>T58586 NZ_CP013395:c749426-749106 [Burkholderia vietnamiensis]
ATGGTGATGCGCGGGGAAGTCTGGTTGGTCGCACTCGATCCGACGCTTGGTAGCGAGATTCAAAAGACGCGCCCCTGTGT
GGTCGTTTCACCTCCCGAAATGCACGACCACTTGCGCACTGTCATCGTCGCGCCGATGACTTCCAAGGGGCGTCCAGTGC
CGTTTCGGATTCCGGTTACGTTCAAGCGCAAACATGGTTTGATCCTTCTGGATCAGATTCGCGCAGTGGACAAGGTGCGC
TTGGTTAAGAAAGAGGGTGCAGTTGCCGATAAAACGTTGTTGGATACCCTGCGGACCTTGCAGGAAGTCTTTGCGGAATA
A

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8979.19 Da        Isoelectric Point: 4.4929

>AT58586 WP_045579168.1 NZ_CP013395:c749668-749420 [Burkholderia vietnamiensis]
MKTTIRRMGNSQGVLIPKPVLAQLGLESEVEMEVENDAIVLRRPKHKAREGWAEASKALAESGDDALVMGEFSNADDAEL
AW

Download         Length: 249 bp

>AT58586 NZ_CP013395:c749668-749420 [Burkholderia vietnamiensis]
ATGAAGACAACGATTCGCAGAATGGGCAACTCGCAGGGCGTGCTGATTCCGAAGCCCGTCCTTGCGCAACTCGGGCTGGA
GAGCGAAGTGGAAATGGAGGTCGAGAACGACGCGATTGTTCTGCGCCGCCCGAAGCACAAAGCCCGTGAGGGGTGGGCGG
AAGCAAGCAAGGCTCTGGCCGAGAGCGGCGACGATGCGCTGGTTATGGGCGAGTTTTCGAACGCCGATGACGCGGAGCTT
GCATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4LIN8

Antitoxin

Source ID Structure
AlphaFold DB A0A1B4LIX1

References