Detailed information of TA system TA058584

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-vagC/VapC-VagC
• Location: 148348..148985
• Replicon: chromosome
• Accession: NZ_CP013393
• Organism: Burkholderia vietnamiensis strain FL-2-3-30-S1-D0

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: WJ02_RS00645
• Protein ID: WP_059454879.1
• Coordinates: 148584..148985 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: -
• Locus tag: WJ02_RS00640
• Protein ID: WP_011882846.1
• Coordinates: 148348..148584 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WJ02_RS00620	143926..144960	+	1035	WP_059454882.1	helix-turn-helix domain-containing protein	-
WJ02_RS00630	145242..146369	-	1128	WP_069221812.1	ADP-heptose--LPS heptosyltransferase	-
WJ02_RS00635	146366..148069	-	1704	WP_069221813.1	thiamine pyrophosphate-binding protein	-
WJ02_RS00640	148348..148584	+	237	WP_011882846.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
WJ02_RS00645	148584..148985	+	402	WP_059454879.1	type II toxin-antitoxin system VapC family toxin	Toxin
WJ02_RS00650	149053..150441	-	1389	WP_014722202.1	L-serine ammonia-lyase	-
WJ02_RS00655	150472..151608	-	1137	WP_045578623.1	alginate lyase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-120)

Antitoxin

• SpoVT-AbrB domain (7-44)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14920.10 Da
• Isoelectric Point: 5.1684

>T58584 WP_059454879.1 NZ_CP013393:148584-148985 [Burkholderia vietnamiensis]
MPRYMLDTNMCIYLMKSQPEQVAKRFAQCYTGDVVMSAITYAELEYGVTLCAAPARERRHLAALIEDIPVAPFDAAAAQA
YGPVRDATRAWKKDHLDKLIAAHAVSLDVVLVTNDERDFASYPGLRLENWLND

Nucleotide

• Length: 402 bp

>T58584 NZ_CP013393:148584-148985 [Burkholderia vietnamiensis]
ATGCCGCGCTACATGCTCGACACCAACATGTGCATCTACTTGATGAAGAGCCAGCCCGAGCAAGTGGCGAAGCGATTTGC
GCAGTGCTACACGGGCGACGTCGTGATGTCGGCGATCACGTATGCCGAGCTGGAGTACGGCGTCACCCTGTGCGCGGCGC
CCGCGCGTGAGCGCCGCCATCTTGCGGCGCTGATCGAGGATATTCCCGTCGCGCCGTTCGACGCCGCGGCCGCGCAAGCA
TATGGGCCGGTGCGTGACGCCACGCGCGCGTGGAAGAAGGATCATCTCGACAAACTGATCGCCGCTCATGCGGTGTCGCT
CGATGTCGTGCTGGTGACGAACGACGAGCGCGATTTCGCGAGCTATCCGGGATTGCGGCTGGAGAACTGGCTGAACGATT
AG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9021.21 Da
• Isoelectric Point: 7.2056

>AT58584 WP_011882846.1 NZ_CP013393:148348-148584 [Burkholderia vietnamiensis]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERIGDEIRIRPARRPLTQVLKKFAKFAPDFMAEGRGDHEQAEREGL

Nucleotide

• Length: 237 bp

>AT58584 NZ_CP013393:148348-148584 [Burkholderia vietnamiensis]
ATGCATACCACGAGGGTATTTCGGAACGGCAATTCGCAGGCCGTGCGAATTCCTGCGGATCTCGCTTATGAGCGCAGCGA
TATCGAGCTCGAGATCGAGCGCATCGGCGACGAGATCCGCATCCGGCCGGCGCGACGGCCGTTGACGCAGGTGCTCAAGA
AGTTCGCGAAGTTCGCGCCCGATTTCATGGCGGAAGGGCGTGGCGACCACGAGCAGGCCGAACGCGAGGGGTTGTGA